Phytochemical, Antihyperglycaemic and Lipid Profile Effects of Methanol Extract Fraction of Ricinus comminus Seeds in Alloxan Induced Diabetic Male Wistar Albino

2015 ◽  
Vol 11 (1) ◽  
pp. 24-33 ◽  
Author(s):  
F.C. Nwodo Okwesili ◽  
C. Nweje-Anyalowu Paul ◽  
E. Joshua Parker ◽  
Uroko Robert Ikechukwu
Keyword(s):  
Lipid Profile ◽  
Methanol Extract ◽  
Extract Fraction

Control of algal growth by macrophytes and macrophyte-extracted bioactive compounds

1996 ◽  
Vol 34 (7-8) ◽  
pp. 227-235 ◽  
Author(s):  
Satoshi Nakai ◽  
Masaaki Hosomi ◽  
Mitumasa Okada ◽  
Akihiko Murakami
Keyword(s):  
Bioactive Compounds ◽  
Methanol Extract ◽  
Heterotrophic Bacteria ◽  
Myriophyllum Spicatum ◽  
Algal Growth ◽  
Selenastrum Capricornutum ◽  
Inhibitory Effects ◽  
Fractionation Process ◽  
Extract Fraction ◽  
Species Specific

Algae (Selenastrum capricornutum and Microcystis aeruginosa) were respectively assayed in a mixed-culture system using various concentrations of macrophytes obtained from Egeria densa, Cabomba caroliniana, and Myriophyllum spicatum in order to evaluate their inhibitory effects on algal growth due to possible secretion of anti-algal bioactive compounds under coexistence conditions. Based on this methodology, we also evaluated the methanol extract from macrophyte tissues, their extract fractions from a polarity-based fractionation process, and the biodegraded filtrate from the most inhibitory fraction of each macrophyte at an initial concentration which was quantitatively confirmed to produce strong inhibition of algal growth, although in this case, heterotrophic bacteria was also added to the assays. Algal assays investigating coexistence showed clear inhibitory effects which confirm the secretion theory, and also indicated the occurrence of a species-specific reaction. In these assays, and in those using the methanol extract fractions, M. spicatum demonstrated the strongest inhibitory effects on both algae. The extract fraction assays showed that in all cases the fraction containing the highest polarized compounds was the most inhibitory one, while the examined filtrates showed rapid biodegradation of all their anti-algal bioactive compounds in parallel with a substantial increase in biomass of heterotrophic bacteria.

scholarly journals Assessment of Fertility Effect and Hypolipidemic Activity of Carica papaya (Linn) Leaf Methanol Extract in Male Diabetic Rats

2021 ◽  
pp. 58-69
Author(s):  
Opeyemi O. Ayodele ◽  
Ifeoluwa M. Dada ◽  
Rotimi K. Adekunle
Keyword(s):  
Lipid Profile ◽  
Plasma Glucose ◽  
Carica Papaya ◽  
Methanol Extract ◽  
Sperm Count ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Albino Rats ◽  
Spectrophotometric Methods

Aim: Diabetes mellitus (DM) is a prevalent metabolic disorder that leads to other microvascular and macrovascular complications. Diabetes affects fertility and blood clotting, and also cause impaired lipid profile thus leading to increased atherogenic risks and coronary diseases. This research investigates the effects of Carica papaya leaf methanol extract on fertility indices and lipid profile of male diabetic rats. Methodology: Male Wistar albino rats were randomly divided into five groups of six rats each. Diabetes was induced in the rats by a single intraperitoneal injection of streptozotocin (55 mg/kg). Diabetic rats were treated orally with 100 and 200 mg/kg C. papaya methanol extract for 14 days. At the end of administration, the plasma glucose concentration and lipid profile were assayed by spectrophotometric methods; seminal analysis was carried out for evaluation of morphology, motility and sperm count under the microscope. The bleeding and clotting times of the rats were also determined. Results: C. papaya leaf methanol extract caused significant (p = 0.05) reduction in plasma glucose, total cholesterol, triglycerides, VLDL-C, LDL-C, bleeding and clotting times of diabetic treated rats, while the HDL-C of treated groups were significantly (p = 0.05) elevated compared to the diabetic control. Percentage normal cells were lower in diabetic control rats (41.4±4.4%) and C. papaya treated groups (50.0±8.5% for 100 mg/kg; 47.5±9.1% for 200 mg/kg) compared with the normal control group (69.5±5.6%). Similar results were recorded for sperm count. The qualitative phytochemical screening showed the presence of steroids, anthraquinone, tannin, and other bioactive compounds. Conclusion: findings from this study indicated that C. papaya leaf methanol extract could possess hypoglycemic and hypolipidemic activities. Thus, could be considered as a potential source of bio pharmacological agent for management and control of DM and its complications. Prolonged administration of C. papaya leaves may negatively affect male fertility.

scholarly journals Beneficial Effects of Pentanema vestitum Linn. Whole Plant on the Glucose and Other Biochemical Parameters of Alloxan Induced Diabetic Rabbits

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Ikram Ilahi ◽  
Ali Asghar ◽  
Shujat Ali ◽  
Murad Khan ◽  
Nasrullah Khan
Keyword(s):  
Lipid Profile ◽  
Biochemical Parameters ◽  
Methanol Extract ◽  
Serum Levels ◽  
Serum Glucose ◽  
Therapeutic Action ◽  
Beneficial Effects ◽  
Whole Plant ◽  
Diabetic Rabbit ◽  
Diabetic Rabbits

The residents of Lower Dir and Malakand agency, Khyber Pakhtunkhwa, Pakistan, use the dry powder of whole plant of Pentanema vestitum for the treatment of asthma and diabetes. No documented reports are available about the therapeutic action of Pentanema vestitum. The present study was aimed to explore the antihyperglycemic effect of 70% methanol extract of Pentanema vestitum whole plant in glucose-induced nondiabetic hyperglycemic and alloxan-induced diabetic rabbits. During this study, the effects of plant extract on the serum lipid profile, GPT, ALP, bilirubin and creatinine of diabetic rabbits were also studied. The extract of Pentanema vestitum whole plant exhibited significant antihyperglycemic activity in glucose-induced hyperglycemic rabbits. Treatment of alloxan-induced diabetic rabbits with extract significantly reduced the elevated levels of serum glucose, GPT, ALP, bilirubin and creatinine. During the study of lipid profile, the extract proved to be antihyperlipidemic and HDL boosting in diabetic rabbit models. From the finding of the present research, it was concluded that the 70% methanol extract of Pentanema vestitum whole plant has beneficial effects on serum levels of glucose, lipid profile, GPT, ALP, bilirubin, and creatinine of diabetic rabbits.

scholarly journals Methanol Extract of Unfermented Theobroma Cacao Promotes Normal Lipid Profile of Wistar Rats

2019 ◽  
Vol Volume-3 (Issue-3) ◽  
pp. 190-193
Author(s):  
Eyuwa Ignatius Agwupuye ◽  
Justin Atiang Beshel ◽  
Assumpta Chioma Anosike | Lawrence U. Ezeanyika ◽  
Keyword(s):  
Lipid Profile ◽  
Theobroma Cacao ◽  
Wistar Rats ◽  
Methanol Extract

scholarly journals ANTIOXIDANT ACTIVITY OF LEAF EXTRACT FROM SIDA SUBCORDATA SPAN

2017 ◽  
Vol 1 (2) ◽  
Author(s):  
Rahma Yulia ◽  
Dachriyanus Dachriyanus ◽  
Amri Bachtiar
Keyword(s):  
Antioxidant Activity ◽  
Ethyl Acetate ◽  
Methanol Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Antioxidant Compounds ◽  
Spectrophotometric Methods ◽  
Dpph Method ◽  
Extract Fraction

This Study has tested the antioxidant activity of the extracts from Sida subcordata Span. Testing is done with antioxidant activity using DPPH method provides. Testing of antioxidant activity in vitro with spectrophotometric methods based on absorbance measurements radical DPPH (1,1-diphenylpicrylhydrazyl). All the extracts Showed radical scavenging activity. The ethyl acetate and methanol extracts were the most Appropriate as sources of antioxidant compounds as shown by Reviews their inhibition percentage (IP) values. Percentage inhibitor to extract ethyl acetate and methanol extract respectively 76.16% and 79.28% at a concentration of 1 mg / ml to 0.05 mM DPPH. while the results of the testing activities of antioxidant compounds y pure ethyl acetate extract fraction showed a smaller percentage inhibitor that is equal to 30% at the same concentration. Keyword - Sida subcordata Span, Malvaceae, Antioxidant, Alkaloid

scholarly journals Reproductive potency of methanolic bi-herbal (Zingiber officinale and Chrysophyllum albidum) extract on masculine wistar rats

2020 ◽  
Vol 9 (5) ◽  
pp. 333-341
Author(s):  
Gabriel Ogunma Benjamin ◽  
◽  
Emmanuel Ola Oshomoh ◽  
Asuelimen Osagie Steve ◽  
Otakhor Kelly Osayi ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Wistar Rats ◽  
Methanol Extract ◽  
Zingiber Officinale ◽  
The Body ◽  
Herbal Extract ◽  
Histopathological Study ◽  
Antioxidant Assay ◽  
Male Wistar Rats ◽  
Fertility Potential

The study is aimed at evaluating the fertility potential of bi-herbal methanol extract on male Wistar rats. This research finding based it fact of fertility in male Wistar rats to investigate through the phytochemicals, antioxidant assay, hormonal indexes, lipid profile, body/organ weight changes and histopathological study across the graded doses (25, 50, 100 mg/kg) of the treated groups of bi-herbal (Zingiber officinale and Chrysophyllum albidum)) methanol extract using standard procedure. Results from the phytochemical screening elicited the essential constituents (alkaloids, flavonoids phenol, tannins and saponnins). The antioxidant assay showed broad scavenging property against free radicals, which possibly is associated with one of its mechanisms of action. An increase in the level of significant (p > 0.05) in hormonal indexes (testosterone, progesterone, follicle stimulating hormone and luteinizing hormone) and slight increase in the level of lipid profile (cholesterol, triglyceride, HDL LDL and VLDL) activities among the treatment groups when compared with the control. There absent significant change (p > 0.05) in the body and testes mass ratio. No pronounce histopathological variation on the testes state in comparative to the control. The dependent from the bi-herbal extract with extreme exhibition of fertility potential as its therapeutic effect

scholarly journals Determination of Plant Constituents in Fractions of Cordia obliqua Willd. Leaf Methanol Extract using GC-MS Analysis

2017 ◽  
Vol 9 (09) ◽  
Author(s):  
R. Gupta ◽  
G. D. Gupta
Keyword(s):  
Methanol Extract ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Deciduous Tree ◽  
Sesquiterpene Alcohol ◽  
Ms Analysis ◽  
Plant Constituents ◽  
Extract Fraction ◽  
Important Medicinal Plant

Cordia obliqua Willd. is an important medicinal plant of family Boraginaceae. It is commonly known as Clammy Cherry. It is a deciduous tree and found throughout Himalayan region in India. Traditionally, it possesses a number of medicinal activities like diuretic, expectorant, antipyretic, anthelmintic and maturant. The current work is aimed to investigate chemical constituents present in fractions of leaf methanol extract of Cordia obliqua plant using GC-MS analysis. Two fractions of methanol extract (CO1 and CO3) were studied and about 30 components were detected in each sample. Highest peak area was observed for moncyclic sesquiterpene alcohol α-Bisabolol oxide b at RT 20.84 in CO1 and for o-methyl-d-glucose at RT 16.53 in CO3. The important constituents detected were Amino acids, Oleic acid, Oleanolic acid, Sesquiterpene lactone, trietrpenoids, various steroids, galactopyranoside, Hexadecanoic acid, Phthalic acid, Azafrin, Decatrienoic acid, Docasenamide, Morphinan and carotenoids. Among these Morphinan is an opoid alkaloid and good psychoactive drug. Other constituents are also medicinally important and many have reported biological activities. Thus GC-MS analysis revealed the existence of various types of constituents in Cordia obliqua leaf methanol extract fraction which confirm the application of this plant for a number of medicinal activities.

scholarly journals Cardioprotective Potential of Methanol Extract of Costus Afer Leaf on Carbon Tetrachloride-Induced Cardiotoxicity in Albino Rats

2017 ◽  
Vol 9 (2) ◽  
pp. 51 ◽  
Author(s):  
U. O. Njoku ◽  
O. F. C. Nwodo ◽  
M. O. Ogugofor
Keyword(s):  
Lipid Peroxidation ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Leaf Extract ◽  
Methanol Extract ◽  
Antioxidant Activities ◽  
Density Lipoprotein ◽  
Albino Rats ◽  
Cardiac Biomarker ◽  
Costus Afer

<em>Costus afer</em> leaf extract is one of the native heritages of folklore medicine in Nigeria, used for the treatment of various disease conditions. Therefore this study was undertaken to evaluate the cardioprotective potential of the methanol extract of <em>Costus afer</em> leaves on CCl<sub>4</sub>- induced cardiotoxicity in albino rats. Twenty-eight (28) albino rats were divided into four main groups: normal control (normal saline only), CCl<sub>4</sub> control (saline and CCl<sub>4</sub>), aspirin treated (1.2 mg/kg b.w aspirin and CCl<sub>4</sub>) and <em>Costus afer</em> extract treated (extract and CCl<sub>4</sub>) groups. <em>Costus afer</em> extract was administered in four doses; 100, 200, 300, and 400 mg/kg b.w. p.o for 7 days. On day 7, CCl<sub>4</sub> (2.5 ml) cardiotoxicity was induced in animals of CCl<sub>4</sub> control, aspirin treated and extract pre-treatment groups. The parameters studied in this respect were cardiac biomarker enzymes; Creatine Kinase (CK), Aspartate Transaminases (AST) and Lactate Dehydrogenase (LDH), serum lipid profile; Triacylglycerol (TAG), Total Cholesterol (TC), Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL) and artherogenic index (AR), lipid peroxidation; malondialdehyde (MDA) level and enzymatic antioxidant levels of cardiac tissue homogenate; Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Reductase (GR). CCl<sub>4</sub> intoxication produced significant (p &lt; 0.05) increases in cardiac biomarker enzymes, serum lipid profile (TAG, TC, and LDL) along with enhanced lipid peroxidation in heart, while significant (p &lt; 0.05) decreases in enzymatic antioxidant activities and HDL contents were also observed when compared to normal control. <em>Costus afer</em> leaf extract protected against  CCl&lt; cardiotoxic effect by restoring the cardiac functions alterations, augmenting antioxidant activities, reducing lipid peroxidation and improving lipid profile levels near normal. From the results, <em>Costus afer</em> leaves expressed cardioprotective potential and could be helpful in the management of cardiac dysfunction.

scholarly journals Hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats

2019 ◽  
Vol 32 (3) ◽  
pp. 125-129
Author(s):  
Samuel O. Onoja ◽  
Gloria Daniel-Igwe ◽  
Emmanuel Ejiofor ◽  
Christiana C. Mbakwe ◽  
Ugochuhwu S. Okeke ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Methanol Extract ◽  
Serum Lipid Profile ◽  
Root Bark ◽  
Hot Air ◽  
Liver And Kidney ◽  
Kidney Functions

Abstract This study evaluated the hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats. The extract of P. pinnata root-bark was prepared using a cold maceration method with 80% methanol and concentrated at 40°C in hot air oven. The extract was administered once daily per os at 50, 100 and 200 mg/kg for 21 consecutive days. Distilled water (5 mL/kg) and glibenclamide (2 mg/kg) were used as the vehicle and reference standard, respectively. The serum lipid profile, markers of liver and kidney functions, antioxidant status (malondialdehyde level, superoxide dismutase and catalase activities), histopathological changes in liver and kidney were examined 24h after the last treatment on day 21. The extract reduced serum lipid profile, markers of liver and kidney functions of treated rats relative to vehicle-treated rats. The superoxide dismutase and catalase activities of the extract treated rats were also elevated relative to the vehicle-treated rats. The extract reversed liver and kidney injuries induced by alloxan in the treated rats. This study provides some basic information which suggest that P. pinnata could be effective in managing diabetic complications.

Sign in / Sign up

Export Citation Format

Share Document