Effect of exercise on gastric health in field retrievers

2016 ◽  
Vol 12 (1) ◽  
pp. 35-39 ◽  
Author(s):  
M.S. Davis ◽  
M.D. Willard ◽  
M.J. Day ◽  
J. McCann ◽  
M. E. Payton ◽  
...  
Keyword(s):  
Gastrointestinal Disease ◽  
Histopathological Examination ◽  
Gastric Disease ◽  
Sled Dogs ◽  
Gastric Endoscopy ◽  
Gastric Biopsies ◽  
Clinically Significant ◽  
Exercise Induced ◽  
Ultra Endurance ◽  
Labrador Retrievers

Exercise-induced gastrointestinal disease (EIGD) has been reported in all domestic athletes. In dogs and humans, EIGD is most commonly associated with ultra-endurance racing sled dogs and marathon/triathlon competitors, respectively, suggesting that the syndrome is specifically a function of prolonged exercise. However, EIGD is also common in horses that exercise for brief periods, and more recently, EIGD has been identified in Labrador retrievers that perform off-leash explosive detection patrols. In this study, we tested the hypothesis that EIGD could be induced in retrievers performing competition-style retrieves. Gastric endoscopy and histopathological examination of gastric biopsies were performed on 10 healthy retrievers before and 24 h after a series of multi-set retrieves totalling over 5 km. Although the exercise challenge resulted in a small but statistically significant increase in gastric endoscopy severity score, it did not result in a higher prevalence of clinically-significant gastric disease or changes in gastric histopathology. We conclude that competitive retrieving is unlikely to induce clinically-significant gastric disease in healthy dogs.

Effect of simulated deployment patrols on gastric mucosa of explosive detection dogs

2014 ◽  
Vol 10 (2) ◽  
pp. 99-103 ◽  
Author(s):  
M.S. Davis ◽  
M.D. Willard ◽  
D. Bowers ◽  
M.E. Payton
Keyword(s):  
Submaximal Exercise ◽  
Military Deployment ◽  
Explosive Detection ◽  
Gastric Disease ◽  
Acid Suppression Therapy ◽  
Before And After ◽  
Exercise Induced ◽  
Ultra Endurance ◽  
Privately Owned ◽  
Labrador Retrievers

Exercise-induced gastric disease is well-recognised in dogs performing ultra-endurance racing, but has not been described in dogs performing non-competitive athletic activities. Explosive detection dogs often perform prolonged periods of exercise and are reported to have chronic inappetance and weight-loss consistent with gastric disease. Seven privately-owned Labrador Retrievers trained for off-leash explosive detection activities were used to test the hypothesis that explosive detection dogs develop exercise-induced gastric disease while performing routine duties. Gastroscopy was performed on dogs before and after a 5-day exercise challenge designed to simulate routine military deployment activities. Five days of sustained submaximal exercise resulted in substantial gastric disease. These results demonstrate that dogs performing prolonged submaximal exercise consistent with off-leash explosive detection patrols are susceptible to exercise-induced gastric disease. Exercise-induced gastric disease may explain the anecdotal reports of poor thrift in these types of dogs during military deployment, and prophylactic acid suppression therapy should be considered in dogs participating in these activities.

scholarly journals Efficacy of Omeprazole for the Prevention of Exercise-Induced Gastritis in Racing Alaskan Sled Dogs

2003 ◽  
Vol 17 (2) ◽  
pp. 163-166 ◽  
Author(s):  
M.S. Davis ◽  
M.D. Willard ◽  
S.L. Nelson ◽  
S.M. McCullough ◽  
R.E. Mandsager ◽  
...  
Keyword(s):  
Sled Dogs ◽  
Exercise Induced

scholarly journals Exercise induced hypercoagulability, increased von Willebrand factor and decreased thyroid hormone concentrations in sled dogs

2014 ◽  
Vol 56 (1) ◽  
Author(s):  
Anne K H Krogh ◽  
Pernille Legind ◽  
Mads Kjelgaard-Hansen ◽  
Louise Bochsen ◽  
Annemarie T Kristensen
Keyword(s):  
Thyroid Hormone ◽  
Von Willebrand Factor ◽  
Sled Dogs ◽  
Exercise Induced ◽  
Von Willebrand ◽  
Willebrand Factor

Incidence of unusual and clinically significant histopathological findings in routine discectomy

2006 ◽  
Vol 5 (5) ◽  
pp. 410-413 ◽  
Author(s):  
Adam S. Wu ◽  
Daryl R. Fourney
Keyword(s):  
Histopathological Examination ◽  
Pathological Examination ◽  
Histopathological Findings ◽  
Retrospective Database Analysis ◽  
Clinically Significant ◽  
Unexpected Findings ◽  
Significant Disease ◽  
Case Basis ◽  
Subsequent Patient ◽  
Retrospective Database

Object Routine histopathological examination of discectomy specimens remains common practice in many hospitals, although it rarely detects unsuspected clinically significant disease. Controversy exists as to the effectiveness of this practice. The objectives of this study were to compare the authors’ experience with a review of the literature. Methods In a retrospective database analysis the authors identified all intervertebral disc specimens obtained during spinal procedures over an 8-year period (1996–2004). Cases of benign (nonneoplastic and noninfectious) indications for surgery were included in the study, whereas cases of nonbenign indications were excluded. The final pathological diagnoses were reviewed, and a chart review was performed to determine whether any unexpected findings affected subsequent patient care. A total of 1858 discectomy specimens were identified: 1775 of these were obtained in 1719 routine discectomy procedures. Unexpected histopathological findings were identified in four cases, and none was clinically significant. Conclusions Routine histopathological examination of disc specimens is not justified. The decision to send specimens for pathological examination should be determined on a case-by-case basis after consideration of the clinical presentation, results of laboratory and imaging studies, and intraoperative findings.

Genotyping of exercise-induced collapse in Labrador retrievers using an allele-specific PCR

2012 ◽  
Vol 193 (1) ◽  
pp. 293-295 ◽  
Author(s):  
Masamine Takanosu ◽  
Hirokazu Mori ◽  
Hiroetsu Suzuki ◽  
Katsushi Suzuki
Keyword(s):  
Specific Pcr ◽  
Allele Specific ◽  
Exercise Induced ◽  
Allele Specific Pcr ◽  
Labrador Retrievers

scholarly journals Measurement of Immunoglobulin Concentrations in the Feces of Healthy Dogs

2004 ◽  
Vol 11 (5) ◽  
pp. 841-848 ◽  
Author(s):  
I. R. Peters ◽  
E. L. Calvert ◽  
E. J. Hall ◽  
M. J. Day
Keyword(s):  
Internal Control ◽  
Gastrointestinal Disease ◽  
Immunoglobulin A ◽  
Iga Deficiency ◽  
German Shepherd ◽  
Chronic Enteropathies ◽  
Relative Deficiency ◽  
Iga Production ◽  
Labrador Retrievers

ABSTRACT Selective immunoglobulin A (IgA) deficiency is the most common primary immunodeficiency in humans and may be associated with chronic gastrointestinal disease. This observation has led to the suggestion that the high susceptibility of German shepherd dogs (GSD) to chronic enteropathies is related to a deficiency in mucosal IgA production. Relative deficiencies of IgA has been reported in the serum, saliva, tears, and feces of GSD both with and without alimentary disease; however, the findings of different studies are not consistent. The aim of this study was to confirm whether a relative deficiency of IgA exists in the feces of GSD. Feces were collected from healthy GSD (n = 209), Labrador retrievers (n = 96), beagles (n = 19), and miniature schnauzers (n = 32). Fecal IgA, IgM, and IgG were measured by capture enzyme-linked immunosorbent assays. Fecal IgG concentrations in the four breed groups were not significantly different. IgA concentrations were significantly greater in miniature schnauzers than in GSD (P = 0.0003) and Labradors (P = 0.0004) but not significantly different from those in beagles. IgM concentrations were significantly greater in miniature schnauzers than in GSD (P < 0.0001), Labradors (P < 0.0001), and beagles (P = 0.0098). These findings do not support the hypothesis that GSD have a relative deficiency in fecal IgA. The differences in immunoglobulin concentrations measured from a single defecation, between individuals of the same breed and between breeds, as well as the lack of an internal control molecule, make the determination of a normal reference range for all dogs impossible. Therefore, the usefulness of fecal immunoglobulin quantification for the assessment of intestinal immunoglobulin secretion in dogs is limited.

scholarly journals Detection of Helicobacter pylori Through Histochemistry & Immunofluorescent Staining in Biopsies of Patients with Chronic Gastritis

2011 ◽  
Vol 34 (4) ◽  
pp. 4-9
Author(s):  
Asia Jahanzeb ◽  
Abdul Hannan Nagi Nagi ◽  
Ayesha Suleman
Keyword(s):  
Helicobacter Pylori ◽  
Chronic Gastritis ◽  
Histopathological Examination ◽  
Endoscopic Examination ◽  
Immunofluorescent Staining ◽  
Rapid Urease Test ◽  
Specific Method ◽  
Total N ◽  
Urease Test ◽  
Gastric Biopsies

Introduction: Helicobacter pylori (H.pylori) is a helix shaped gram negative rod which is usually associated with chronic gastritis and also a major cause of other astroduodenal diseases as well. Aims & Objectives: The present study used histochemical and immunofluorescent stains on formalin fixed paraffin embedded human gastric biopsies for detection of H.pylori. Comparison was also done to evaluate best staining method. Place and duration of study: This study was accomplished in about one year. Sampling of gastric biopsies and rapid urease test were executed at the endoscopy suite of Lahore General Hospital whereas the histopathological examination and immunofluorescent staining were done in University of Health Sciences, Lahore. Material & Methods: Thirty patients (n=30cases) were included in the study following inclusion criteria. Diagnostic upper GI endoscopy was carried out in all cases. Five gastric biopsies were taken from each patient/case (total N=150 Biopsies) according to the Updated Sydney System. Rapid urease test was performed at the site of endoscopy. Biopsies fixed in 10% formalin were brought to the concerned department where they were assigned a specific laboratory number then processed and stained. Results: Endoscopic examination revealed chronic gastritis and rapid urease tests were positive. All cases (n=30) were positive for H.pylori on histopathology. The calculated sensitivity and specificity of H&E, Giemsa, Modified McMullen’s stain and Immunofluorescent method in present study were 71% and 100%,83% and 100%, 82% and 100%, 90% and 100% respectively. Conclusion: Special stains makes H.pylori identification easier in tissue sections. However, immunofluorescent test is the most sensitive and specific method as compared to histochemical stains.

scholarly journals Efficacy of Famotidine for the Prevention of Exercise-Induced Gastritis in Racing Alaskan Sled Dogs

2007 ◽  
Vol 21 (5) ◽  
pp. 924-927 ◽  
Author(s):  
Katherine K. Williamson ◽  
Michael D. Willard ◽  
Erica C. McKenzie ◽  
Christopher M. Royer ◽  
Mark E. Payton ◽  
...  
Keyword(s):  
Sled Dogs ◽  
Exercise Induced
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