Are probiotics an appropriate treatment option for all women?

2020 ◽  
Vol 11 (3) ◽  
pp. 303-303
Author(s):  
N.C. Rubas
Keyword(s):  
Ethnic Groups ◽  
Treatment Option ◽  
Study Design ◽  
Clinical Applications ◽  
Appropriate Treatment ◽  
Caucasian Women ◽  
Insight Into

The recently published article by P. Tsimaris et al. (2019) gave great prospective insight into non-traditional clinical applications of probiotic use as alternative and/or complementary therapeutics to traditional antibiotics for treatment of vulvovaginitis. However, these findings are too broad to be generalised as a treatment option for all women. The study design includes a cohort of Caucasian women and does not represent women of other ethnic groups.

scholarly journals TRADITIONAL BONESETTERS

2016 ◽  
Vol 23 (06) ◽  
pp. 699-704
Author(s):  
Waqar Alam ◽  
Faaiz Ali Shah ◽  
Ashfaq Ahmed ◽  
Saeed Ahmad ◽  
Abdullah Shah
Keyword(s):  
Compartment Syndrome ◽  
Study Design ◽  
Low Cost ◽  
Cultural Beliefs ◽  
Case Series ◽  
Non Union ◽  
Appropriate Treatment ◽  
Accident And Emergency ◽  
Set Up ◽  
Study District

Objectives: To analyze the reasons for treatment by Traditional Bone Setters(TBS) and the frequency of complications in patients treated by traditional bone setters in our setup. Study Design: Descriptive case series. Place and Duration of Study: District HeadquarterHospital (DHQ) Temargarah & Lady Reading Hospital Peshawar and, Ghurki Trust TeachingHospital, Lahore from Dec 2014 to Nov 2015. Material and Methods: Patients of either genderor all ages received in outpatient department or accident and emergency of DHQ Temargarah,Lady Reading Hospital Peshawar and Ghurki Trust Teaching Hospital, Lahore with history oftrauma followed by treatment by local bonesetters were included in our study. After properhistory, examinations and investigations, appropriate treatment were given and complicationswere noted. Results: We received a total of 267 patients who were treated by Traditional bonesetters.186 were males and 81 were females. Age ranges from 1.5 years to 87 years. In majorityAdvice or pressure from family/friends taking the lead. 77(28.84%) of patients suffer because offamily or friends. 66(24.72%) of patients affected because of socio cultural beliefs, 46(17.23%)because of low cost, 35(13.11%) because of ignorance, 24(8.98%) because of fear of operation,19(7.12%) because of fear of amputation took their treatment from bone setters. The mostfrequent complication we received was malunion were found in 67(25.10%) and non-union in55(20.60%), Conclusion: Pressure from friends and family was the main reason for consultingTraditional Bone Setters for treatment in our set up and complications caused by their treatmentwere frequent and ranged from immediate compartment syndrome and gangrene of the limb tolate onset mal union, non-union and avascular non-union.

scholarly journals Cessation strategies used successfully by individuals in recovery from methamphetamine addiction

2021 ◽  
Vol 33 (2) ◽  
pp. 32-44
Author(s):  
Yvonne Gordon ◽  
Christine Stephens
Keyword(s):  
New Zealand ◽  
Lived Experience ◽  
Interpretative Phenomenological Analysis ◽  
Health Issue ◽  
Aotearoa New Zealand ◽  
Appropriate Treatment ◽  
Important Health ◽  
Important Health Issue ◽  
Depth Interviews ◽  
Insight Into

INTRODUCTION: Methamphetamine (MA) misuse is a recognised health issue in Aotearoa New Zealand, and there is a lack of appropriate treatment available for individuals who are methamphetamine dependent. This exploratory study, undertaken in 2019, sought to gain insight from individuals in Aotearoa who have experienced MA dependence and now identify as being in recovery, to discover which strategies, approaches or treatment appeared helpful in their recovery.METHODS: The participants in the study were seven adults (New Zealand European, Samoan and Māori ethnicity) who had abstained from methamphetamine for six months or more. In-depth interviews were audiotaped and transcribed before being analysed. The data were analysed using interpretative phenomenological analysis, which has its theoretical origins in phenomenology and hermeneutics.FINDINGS: Four themes emerged to describe the lived experience of recovery from methamphetamine misuse: Getting Away, Support, Personal Sources of Strength, and Treatment. Each theme held importance in the participants’ recovery from MA and provided insight into their journey in abstaining and being in recovery.CONCLUSIONS: These findings may be used to assist others entering recovery. The present findings are limited by the size of the sample; however, they provide valuable information on this important health issue as a basis for further research, which is urgently needed in Aotearoa.

Choosing the Most Appropriate Treatment Option for Pelvic Venous Disease: Stenting versus Embolization

2021 ◽  
Vol 38 (02) ◽  
pp. 182-188
Author(s):  
Mari E. Tanaka ◽  
Oleksandra Kutsenko ◽  
Gloria Salazar
Keyword(s):  
Treatment Option ◽  
Pelvic Pain ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Central Venous ◽  
Central Venous Stenosis ◽  
Appropriate Treatment ◽  
Ongoing Development ◽  
Venous Stents ◽  
Vein Reflux

AbstractPelvic venous disease (PeVD) in women encompasses a wide variety of entities all resulting in pelvic pain and varices. Successful treatment with percutaneous interventions is dependent on identifying underlying factors contributing to the disease and addressing them with either embolization of incompetent veins or stenting for venous stenoses. There are a multitude of embolization methods with marked practice heterogeneity. Moreover, with the ongoing development of dedicated venous stents in the treatment of chronic venous disease, there are more opportunities to consider this modality for the treatment of PeVD, as many patients present with combined vein reflux and central venous stenosis. The necessity to address both and the order of interventions in these patients is still to be elucidated. Here, we describe when to choose stenting or embolization for PeVD, their limitations, and our practice and identify further areas of research in this field.

APATITIC NANOPOWDERS AND COATINGS: A COMPREHENSIVE REVIEW

2021 ◽  
Author(s):  
RAVINDER PAL SINGH ◽  
UMA BATRA
Keyword(s):  
Sol Gel ◽  
Dip Coating ◽  
Clinical Applications ◽  
Hard Tissue ◽  
Preparation Methods ◽  
Comprehensive Review ◽  
Metallic Substrates ◽  
Surface Modification Techniques ◽  
Dental Applications ◽  
Insight Into

The use of artificial biomaterials has been acclaiming potential therapeutic scope in diverse clinical applications. This review started with the description of the basics of biomaterials, and desirable properties, which are the prerequisites to understand biomaterials. The orthopedic biomaterials, their classification and the importance of calcium phosphate (CaP) materials for hard-tissue applications were utterly discussed. Furthermore, among the various CaP biominerals, the importance of hydroxyapatite (HAP) and its synthesis techniques was comprehensively reviewed. The sol–gel route for the synthesis of HAP nanoparticles and deposition of coatings were systematically studied. Among the metallic substrates, Ti6Al4V alloy remained the focus of this study. Moreover, several film pre-preparation methods were also given due importance. The importance of other surface modification techniques, especially in the context of Ti6Al4V substrates, was also discussed. Among several coating techniques to deposit CaP coatings, special attention was paid to the spin and dip coating techniques. In addition to monolithic HAP coatings, reinforced and antimicrobial HAP coatings were also reviewed from broad perspectives. Therefore, this review provides an in-depth insight into the preparation and properties of apatitic nanoparticles and their coatings for orthopedic and dental applications.

scholarly journals A Review and Clinical Understanding of Tenofovir: Tenofovir Disoproxil Fumarate versus Tenofovir Alafenamide

2020 ◽  
Vol 19 ◽  
pp. 232595822091923
Author(s):  
Chanie Wassner ◽  
Nicole Bradley ◽  
Yuman Lee
Keyword(s):  
Antiretroviral Therapy ◽  
Tenofovir Disoproxil Fumarate ◽  
Medical Condition ◽  
Clinical Applications ◽  
Chronic Medical Condition ◽  
Efficacy And Safety ◽  
Hiv Resistance ◽  
History Of ◽  
Tenofovir Alafenamide ◽  
Insight Into

HIV is a serious chronic medical condition. Significant improvements in antiretroviral therapy have led to a transformation in its management. No curative treatment is available for HIV, and lifelong therapy is required with a combination of agents to control viral replication and prevent complications. Some of the older agents are notorious for many side effects, making patient compliance difficult, which is critical to preventing HIV resistance. Tenofovir is one of the newer, more tolerable, nucleotide reverse transcriptase inhibitors on the market; is a mainstay of many antiretroviral therapy combinations; and is now available in 2 different formulations, tenofovir disoproxil fumarate (TDF) and, the more recent, tenofovir alafenamide (TAF). These 2 formulations have very different pharmacokinetics, which seem to affect their efficacy and safety. This manuscript provides insight into the history of TDF and TAF development, their unique pharmacokinetics and pharmacology, clinically important adverse effects, monitoring, interactions, resistance, review of clinical studies, and guideline recommendations and clinical applications for tenofovir’s various indications.

scholarly journals Alpha-2 Adrenergic Receptor Agonists: A Review of Current Clinical Applications

2015 ◽  
Vol 62 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Joseph A. Giovannitti ◽  
Sean M. Thoms ◽  
James J. Crawford
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Adrenergic Receptor ◽  
Historical Perspective ◽  
Drug Class ◽  
Clinical Applications ◽  
Receptor Agonists ◽  
Panic Disorders ◽  
Hyperactivity Disorder ◽  
Cigarette Craving ◽  
Insight Into

Abstract The α-2 adrenergic receptor agonists have been used for decades to treat common medical conditions such as hypertension; attention-deficit/hyperactivity disorder; various pain and panic disorders; symptoms of opioid, benzodiazepine, and alcohol withdrawal; and cigarette craving.1 However, in more recent years, these drugs have been used as adjuncts for sedation and to reduce anesthetic requirements. This review will provide an historical perspective of this drug class, an understanding of pharmacological mechanisms, and an insight into current applications in clinical anesthesiology.

Gastroesophageal Junction Tumors Does Location Determine Treatment?

2017 ◽  
Author(s):  
Emily L. Siegel ◽  
Miguel Burch
Keyword(s):  
Study Design ◽  
Clinical Case ◽  
Classification Scheme ◽  
Treatment Approach ◽  
Gastroesophageal Junction ◽  
Design Study ◽  
Appropriate Treatment ◽  
Study Intervention ◽  
Landmark Study

This chapter summarizes a landmark study in treatment of gastroesophageal (GE) junction tumors. Should an anatomically based classification scheme of GE tumors define the appropriate treatment approach for these tumors? Starting with that question, it describes the basis of the study, including funding, year study began, year study was published, study location, who was studied, who was excluded, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, gives a summary and discusses implications, and concludes with a relevant clinical case involving possible gastrectomy and esophagectomy.

scholarly journals Commentary on the Recent FSH Collection: Known Knowns and Known Unknowns

Endocrinology ◽  
2019 ◽  
Vol 161 (1) ◽  
Author(s):  
Djurdjica Coss
Keyword(s):  
Cell Function ◽  
Follicle Stimulating Hormone ◽  
Reproductive Function ◽  
Clinical Applications ◽  
Follicular Growth ◽  
Significant Progress ◽  
Known Unknowns ◽  
Near Future ◽  
Insight Into ◽  
Made In

Abstract Follicle-stimulating hormone (FSH) is a dimeric glycoprotein secreted by the anterior pituitary gonadotrope that is necessary for reproductive function in mammals. FSH primarily regulates granulosa cells and follicular growth in females, and Sertoli cell function in males. Since its identification in the 1930s and sequencing in the 1970s, significant progress has been made in elucidating its regulation and downstream function. Recent advances provide deeper insight into FSH synthesis, and effects in the gonads suggest potential roles in extragonadal tissues and examine pharmacological approaches and clinical applications in infertility treatment that now affect 18% of couples. These advances were discussed in detail in a number of reviews published in the last 2 years in Endocrinology. In this brief commentary, we summarize these reviews and point to the outstanding questions that should be answered in the near future to bridge a gap in our understanding of this hormone.

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