Prebiotics and probiotics: the prevention and reduction in severity of atopic dermatitis in children

2014 ◽  
Vol 5 (2) ◽  
pp. 151-160 ◽  
Author(s):  
N. Foolad ◽  
A.W. Armstrong
Keyword(s):  
Atopic Dermatitis ◽  
Lactobacillus Rhamnosus ◽  
Narrative Review ◽  
Lactobacillus Rhamnosus Gg ◽  
Single Strain ◽  
Probiotic Strains

The purpose of this review was to identify whether supplementation with prebiotics and/or probiotics help prevent the development or reduce the severity of atopic dermatitis in children less than three years of age. Since 1997, immunostimulatory supplements, such as prebiotics and probiotics, have been investigated. Various supplementations include probiotics (single strain or mix), probiotics with formula, probiotics mix with prebiotics, and prebiotics. In this narrative review, we examined 13 key articles on prebiotics and/or probiotics, and their effects on infant atopic dermatitis. Among the selected studies, a total of 3,023 participants received supplements or placebo. Eight out of the 13 (61.5%) studies reported a significant effect on the prevention of atopic dermatitis after supplementation with probiotics and/or prebiotics. Five out of the 13 (38.5%) studies indicated significant reduction in the severity of atopic dermatitis after supplementation. Based on the available studies, supplementation with certain probiotics (Lactobacillus rhamnosus GG) appears to be an effective approach for the prevention and reduction in severity of atopic dermatitis. A mix of specific probiotic strains prevented atopic dermatitis among infants. Based on studies with prebiotics, there was a long-term reduction in the incidence of atopic dermatitis. Supplementation with prebiotics and probiotics appears useful for the reduction in the severity of atopic dermatitis. Additional interventional studies exploring prebiotics and probiotics are imperative before recommendations can be made.

scholarly journals PROBIOTIC STRAINS OF LACTOBACILLI AS IMMUNOMODULATORS: FOCUS ON LACTOBACILLUS RHAMNOSUS GG

2017 ◽  
pp. 108-115 ◽  
Author(s):  
O. V. KALYUZHIN
Keyword(s):  
Atopic Dermatitis ◽  
Respiratory Infections ◽  
Lactobacillus Rhamnosus ◽  
Evidence Base ◽  
Lactobacillus Rhamnosus Gg ◽  
Treatment And Prevention ◽  
Intestinal Dysbiosis ◽  
Genus Lactobacillus ◽  
Adjuvant Vaccine ◽  
Probiotic Strains

Probiotics have long been considered not only as a way of correcting intestinal dysbiosis but also as a promising immunomodulatory solution. Over the past years, the evidence base for their effectiveness in the prevention and treatment of immuneassociated human diseases has substantially increased, the previously described mechanisms were specified and new components of the immunocorrective effect of probiotic bacteria, including those belonging to the genus Lactobacillus, have been deciphered. The meta-analytical findings and systematic reviews leave no doubt about the advisability of using certain probiotics, primarily Lactobacillus rhamnosus GG (LGG), in children for the treatment and prevention of various forms of acute diarrhea, including those associated with the administration of antibacterial agents, as well as for the prevention of respiratory infections. The results of testing the strain to be used as an adjuvant vaccine and a way of preventing atopic dermatitis are encouraging. The review analyzes the specific characteristics of present-day children who are more susceptible to allergic and infectious diseases, effector molecules of lactobacilli and signaling pathways that ensure their immunomodulatory effect, the main areas of therapeutic and preventive application and safety of probiotics, with a focus on LGG as one of the most studied and tested strains. In addition, the clinical efficacy of the synbiotic Normobakt L, a combination of LGG (4 × 109) plus fructooligosaccharides (800 mg),which has been approved in Russia for use in children with rotavirus infection against a background of atopic dermatitis, is demonstrated

Randomized, placebo-controlled trial of Lactobacillus rhamnosus GG as treatment of atopic dermatitis in infancy

Allergy ◽  
2007 ◽  
Vol 62 (11) ◽  
pp. 1270-1276 ◽  
Author(s):  
C. Grüber ◽  
M. Wendt ◽  
C. Sulser ◽  
S. Lau ◽  
M. Kulig ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Controlled Trial ◽  
Lactobacillus Rhamnosus ◽  
Lactobacillus Rhamnosus Gg

scholarly journals Lactobacillus rhamnosus GG: experience in pediatric gastroenterology

2020 ◽  
Vol 64 (6) ◽  
pp. 20-29
Author(s):  
I. N. Zakharova ◽  
E. Yu. Borzova ◽  
M. A. Simakova
Keyword(s):  
Eradication Therapy ◽  
Lactobacillus Rhamnosus ◽  
Modern Science ◽  
Host Cells ◽  
Current Evidence ◽  
Human Organism ◽  
Good Growth ◽  
Lactobacillus Rhamnosus Gg ◽  
Treatment And Prevention ◽  
Probiotic Strains

Human organism is considered as a symbiotic microorganism according to the standpoint of modern science which number of commensal microbes is many times greater than the number of host cells. Normal human microbiota is involved in many physiological processes in the organism, and dysbiosis is associated with the development of a number of diseases. The accumulated knowledge about the composition of the normal microbiome allowed to suggest that its modification can change the course of the disease, and so the study of probiotics was initiated. One of the most studied probiotic strains is Lactobacillus rhamnosus GG (GG), ATCC 53103, isolated in 1985. Due to the strain’s resistance to acid and bile, good growth characteristics and the ability to adhere to the intestinal epithelial layer, Lactobacillus rhamnosus GG is most widely used in a variety of commercially available probiotic products. The article provides a review of the literature on the studies of this probiotic in the treatment and prevention of gastroenterological pathology in children, in particular, current evidence of the effectiveness of Lactobacillus rhamnosus GG in the treatment of acute gastroenteritis, antibiotic-associated diarrhea, as well as the results of studies in necrotizing enterocolitis, functional disorders of the intestine, in the eradication therapy for infection caused by Helicobacter pylori.

Ingestion of heat-treated Lactobacillus rhamnosus GG prevents development of atopic dermatitis in NC/Nga mice

2007 ◽  
Vol 37 (2) ◽  
pp. 296-303 ◽  
Author(s):  
J. Sawada ◽  
H. Morita ◽  
A. Tanaka ◽  
S. Salminen ◽  
F. He ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Lactobacillus Rhamnosus ◽  
Lactobacillus Rhamnosus Gg ◽  
Heat Treated

scholarly journals Lactobacillus rhamnosus GG soluble mediators ameliorate early life stress-induced visceral hypersensitivity and changes in spinal cord gene expression

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Karen-Anne McVey Neufeld ◽  
Conall R. Strain ◽  
Matteo M. Pusceddu ◽  
Rosaline V. Waworuntu ◽  
Sarmauli Manurung ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Life Stress ◽  
Early Life ◽  
Maternal Separation ◽  
Lactobacillus Rhamnosus ◽  
Early Life Stress ◽  
Visceral Hypersensitivity ◽  
Visceral Sensitivity ◽  
Lactobacillus Rhamnosus Gg ◽  
Probiotic Strains

Abstract Visceral hypersensitivity is a hallmark of many functional and stress-related gastrointestinal disorders, and there is growing evidence that the gut microbiota may play a role in its pathophysiology. It has previously been shown that early life stress-induced visceral sensitivity is reduced by various probiotic strains of bacteria (including Lactobacillus rhamnosus GG (LGG)) alone or in combination with prebiotic fibres in rat models. However, the exact mechanisms underpinning such effects remain unresolved. Here, we investigated if soluble mediators derived from LGG can mimic the bacteria’s effects on visceral hypersensitivity and the microbiota–gut–brain axis. Rats were exposed to maternal separation (MS) from postnatal days 2–12. From weaning onwards both non-separated (NS) and MS offspring were provided drinking water with or without supplementation of standardized preparations of the LGG soluble mediators (LSM). Our results show that MS led to increased visceral sensitivity and exaggerated corticosterone plasma levels following restraint stress in adulthood, and both of these effects were ameliorated through LSM supplementation. Differential regulation of various genes in the spinal cord of MS versus NS rats was observed, 41 of which were reversed by LSM supplementation. At the microbiota composition level MS led to changes in beta diversity and abundance of specific bacteria including parabacteroides, which were ameliorated by LSM. These findings support probiotic soluble mediators as potential interventions in the reduction of symptoms of visceral hypersensitivity.

scholarly journals Intestinal microbiota: updated evidence-based data on the efficacy of Lactobacillus rhamnosus GG and Bifidobacterium longum in pediatric practice

2018 ◽  
pp. 175-180
Author(s):  
A. V. Gorelov ◽  
E. V. Kanner ◽  
M. L. Maximov ◽  
A. S. Ermolaeva ◽  
A. A. Voznesenskaya ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Bifidobacterium Longum ◽  
Lactobacillus Rhamnosus ◽  
Lactobacillus Rhamnosus Gg ◽  
Composition Formation ◽  
Probiotic Strains ◽  
Paediatric Practice ◽  
The Relationship ◽  
Pathology Data

The article presents updated data on the composition, formation and role of the intestinal microbiota. It shows the relationship between changes in the intestinal microbiota and the formation of various forms of pathology. Data on the effectiveness of the prophylactic and therapeutic effect of probiotic strains, most often used in paediatric practice, are provided. 

scholarly journals The effectiveness of the combination of Lactobacillus rhamnosus GG and prebiotics in the treatment of atopic dermatitis in children

2021 ◽  
pp. 52-56
Author(s):  
T. G. Malanicheva ◽  
N. V. Ziatdinova ◽  
I. N. Serdinskaya
Keyword(s):  
Blood Pressure ◽  
Atopic Dermatitis ◽  
Clinical Efficacy ◽  
Comparison Group ◽  
Lactobacillus Rhamnosus ◽  
Main Group ◽  
Lactobacillus Rhamnosus Gg ◽  
Old Patients ◽  
Clinical Methods ◽  
Complex Therapy

Introduction. Traditional antiallergic therapy for atopic dermatitis, including allergen elimination, therapeutic cosmetic skin care, external anti-inflammatory therapy and antihistamines, does not always lead to the desired result. On this basis, the search for new methods of treatment is urgent and promisingAim. To study the clinical efficacy of a combination of Lactobacillus rhamnosus GG and prebiotics in children in the first years of life with atopic dermatitis (AD).Materials and methods. The observed children were divided into 2 parts: 30 children aged from 1 month to 3 years old, patients with AD constituted the main group, it differed in that these patients were synbiotic (combination of Lactobacillus rhamnosus GG and prebiotics) – 1 sachet per day for 14 days. This drug was prescribed as part of complex therapy. The remaining 25 children with AD made up a comparison group, which was characterized by the fact that children received only antiallergic therapy without symbiotic. Clinical methods of blood pressure examination, laboratory instrumental and specific allergological methods were carried out.Results and discussion. Against the background of the therapy in children with blood pressure in the main group, общий overall treatment effect was higher and amounted to 86.6 + 4.0%, and in the comparison group – 76.0 + 3.9%, p < 0.05. This was manifested in a decrease in the duration of the exacerbation period by 1.4 times, the prevalence of a high individual therapeutic effect by 1.5 times, a decrease in the SCORAD index by 4 times against the background of an increase in the number of bifidobacteria and lactobacilli in the intestine. The revealed clinical efficacy was noted against the background of an increase in the number of bifidobacteria and lactobacilli in the intestine.Conclusions. The obtained results allow us to recommend a combination of Lactobacillus rhamnosus GG and prebiotics in children in the first years of life as part of complex therapy to increase the effectiveness of treatment.

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