scholarly journals Gastric Plasmacytoma Associated with Multiple Metastases in a Patient who Survived More Than 3 Years

2017 ◽  
Vol 78 (12) ◽  
pp. 2646-2651
Author(s):  
Namiko IMAMURA ◽  
Kimihiko KUSASHIO ◽  
Jyun YASUTOMI ◽  
Masanari MATSUMOTO ◽  
Takeshi SUZUKI ◽  
...  
Keyword(s):  
Multiple Metastases ◽  
Gastric Plasmacytoma

Multiple Metastases of Paraganglioma: A case report

1996 ◽  
Vol 34 (4) ◽  
pp. 469
Author(s):  
Jin Yong Seong ◽  
Sung Tae Kim ◽  
Seoung Ro Lee ◽  
Chang Kok Hahm ◽  
Dong Woo Park ◽  
...  
Keyword(s):  
Case Report ◽  
Multiple Metastases

Long-term management of patients with multiple brain metastases after shaped beam radiosurgery

2004 ◽  
pp. 406-412
Author(s):  
Paul Okunieff ◽  
Michael C. Schell ◽  
Russell Ruo ◽  
E. Ronald Hale ◽  
Walter G. O'Dell ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Tumor Control ◽  
Content Type ◽  
Negative Results ◽  
Multiple Metastases ◽  
Extracranial Disease ◽  
Successful Control ◽  
The Brain

✓ The role of radiosurgery in the treatment of patients with advanced-stage metastatic disease is currently under debate. Previous randomized studies have not consistently supported the use of radiosurgery to treat patients with numbers of brain metastases. In negative-results studies, however, intracranial tumor control was high but extracranial disease progressed; thus, patient survival was not greatly affected, although neurocognitive function was generally maintained until death. Because the future promises improved systemic (extracranial) therapy, the successful control of brain disease is that much more crucial. Thus, for selected patients with multiple metastases to the brain who remain in good neurological condition, aggressive lesion-targeting radiosurgery should be very useful. Although a major limitation to success of this therapy is the lack of control of extracranial disease in most patients, it is clear that well-designed, aggressive treatment substantially decreases the progression of brain metastases and also improves neurocognitive survival. The authors present the management and a methodology for rational treatment of a patient with breast cancer who has harbored 24 brain metastases during a 3-year period.

scholarly journals Germline Whole-Gene Deletion of FH Diagnosed from Tumor Profiling

2021 ◽  
Vol 22 (15) ◽  
pp. 7962
Author(s):  
Arisa Ueki ◽  
Kokichi Sugano ◽  
Kumiko Misu ◽  
Eriko Aimono ◽  
Kohei Nakamura ◽  
...  
Keyword(s):  
Fumarate Hydratase ◽  
European Origin ◽  
Pathogenic Variants ◽  
Multiple Metastases ◽  
History Of ◽  
Genetic Deletion ◽  
Aggressive Clinical Course ◽  
Written Informed Consent ◽  
Tumor Profiling

Hereditary leiomyomatosis and renal cell carcinoma (HL (RCC)) entails cutaneous and uterine leiomyomatosis with aggressive type 2 papillary RCC-like histology. HLRCC is caused by pathogenic variants in the FH gene, which encodes fumarate hydratase (FH). Here, we describe an episode of young-onset RCC caused by a genomic FH deletion that was diagnosed via clinical sequencing. A 35-year-old woman was diagnosed with RCC and multiple metastases: histopathological analyses supported a diagnosis of FH-deficient RCC. Although the patient had neither skin tumors nor a family history of HLRCC, an aggressive clinical course at her age and pathological diagnosis of FH-deficient RCC suggested a germline FH variant. After counseling, the patient provided written informed consent for germline genetic testing. She was simultaneously subjected to paired tumor profiling tests targeting the exome to identify a therapeutic target. Although conventional germline sequencing did not detect FH variants, exome sequencing revealed a heterozygous germline FH deletion. As such, paired tumor profiling, not conventional sequencing, was required to identify this genetic deletion. RCC caused by a germline FH deletion has hitherto not been described in Japan, and the FH deletion detected in this patient was presumed to be of maternal European origin. Although the genotype-phenotype correlation in HLRCC-related tumors is unclear, the patient’s family was advised to undergo genetic counseling to consider additional RCC screening.

Use of genetic algorithm for PTV optimization in single isocenter multiple metastases radiosurgery treatments with Brainlab Elements™

2021 ◽  
Vol 86 ◽  
pp. 82-90
Author(s):  
José Alejandro Rojas-López ◽  
Rogelio Manuel Díaz Moreno ◽  
Carlos Daniel Venencia
Keyword(s):  
Genetic Algorithm ◽  
Multiple Metastases ◽  
Single Isocenter

scholarly journals Current treatment of patients with multiple brain metastases

2000 ◽  
Vol 9 (2) ◽  
pp. 1-5 ◽  
Author(s):  
Steven D. Chang ◽  
John R. Adler
Keyword(s):  
Brain Metastases ◽  
Treatment Options ◽  
Whole Brain Radiotherapy ◽  
Mass Effect ◽  
Current Treatment ◽  
Rapid Reduction ◽  
Multiple Brain Metastases ◽  
Brain Radiotherapy ◽  
Multiple Metastases ◽  
Difficult Challenge

The management of patients with multiple brain metastases remains a difficult challenge for neurosurgeons. This patient population has a poor prognosis when compared with those harboring a solitary brain metastasis, and historically treatment has generally consisted of administering whole-brain radiotherapy once the diagnosis of multiple brain metastases is made. Resection can be useful in a subset of patients with multiple metastases in whom one or two of the lesions are symptomatic, as this may provide rapid reduction of mass effect and edema. Furthermore, the authors of recent studies have shown that stereotactic radiosurgery can be used in certain patients with multiple brain metastases as part of the treatment regimen. In this review the authors outline the treatment options and indications as well as a management strategy for the treatment of patients with multiple brain metastases.

scholarly journals Spontaneous Metastatic Angiosarcoma of the Tongue in a Wistar Rat

2010 ◽  
Vol 38 (3) ◽  
pp. 472-475 ◽  
Author(s):  
V. Pace ◽  
G. Wieczorek ◽  
M. Pace ◽  
K. Weber ◽  
E. Perentes
Keyword(s):  
Primary Tumor ◽  
Lung Metastases ◽  
Wistar Rat ◽  
Dorsal Part ◽  
Primary Angiosarcoma ◽  
Toxicology Study ◽  
Multiple Metastases ◽  
Collagenous Stroma ◽  
Von Willebrand ◽  
Willebrand Factor

A primary angiosarcoma was found in the tongue of a six-week-old female Wistar rat, sacrificed for humane reasons during the course of a four-week toxicology study. At necropsy, a nodule protruding from the dorsal part of the tongue was found. The nodule displayed microscopically, irregularly shaped vascular spaces separated by collagenous stroma. The spindle-shaped endothelial cells showed pleomorphism, hyperchromatism, and low mitotic activity; large nuclei with one or more nucleoli were present. Multiple metastases were found in the lungs, and the morphology of the cells resembled that of the primary tumor. Immunohistochemically, the primary tumor and the lung metastases were positive for von Willebrand factor and vimentin. The diagnosis of tongue angiosarcoma metastasizing to the lungs was made on the basis of microscopic and immunohistochemical findings.

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