scholarly journals A Case of Neuroendocrine Carcinoma with Adenocarcinoma Component of the Gallbladder

2016 ◽  
Vol 77 (4) ◽  
pp. 955-960
Author(s):  
Takahiro MIZUI ◽  
Masahiro USUDA ◽  
Wataru NAKANISHI ◽  
Tsukasa INOUE ◽  
Go MIYATA ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Adenocarcinoma Component

scholarly journals Advanced Gastric Neuroendocrine Carcinoma with an Adenocarcinoma Component

2012 ◽  
Vol 6 (1) ◽  
pp. 52-57 ◽  
Author(s):  
Masashi Miguchi ◽  
Masahiko Iseki ◽  
Kunihiko Shimatani
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Gastric Neuroendocrine Carcinoma ◽  
Adenocarcinoma Component

Neuroendocrine carcinoma of the esophagus with an adenocarcinoma component

2019 ◽  
Vol 12 (6) ◽  
pp. 534-538
Author(s):  
Yuki Kaneko ◽  
Shin Saito ◽  
Kazuya Takahashi ◽  
Rihito Kanamaru ◽  
Yoshinori Hosoya ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Carcinoma Of The Esophagus ◽  
Adenocarcinoma Component

Mixed Neuroendocrine-Nonneuroendocrine Carcinoma Arising in the Gallbladder: A Rare Case of a Three-Component Composite Neoplasm

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S121-S121
Author(s):  
Mouyed Alawad ◽  
Scott Schoninger ◽  
Raavi Gupta
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Squamous Cell ◽  
Treatment Guidelines ◽  
Specific Treatment ◽  
Neuroendocrine Neoplasms ◽  
Mitotic Figures ◽  
Adenocarcinoma Component ◽  
Gross Examination

Abstract Introduction Neuroendocrine gallbladder neoplasms are rare, comprising 0.5% of all neuroendocrine cancers and about 2% of gallbladder cancers. Interestingly, those neoplasms can also be observed along with other malignant components of epithelial origin, mostly adenocarcinomas. Herein we report an unusual case of a patient with a gallbladder neoplasm composed of a neuroendocrine carcinoma, a squamous cell carcinoma, and an adenocarcinoma. Methods The patient was a 62-year-old woman who presented with right upper quadrant abdominal pain with a positive Murphy’s sign on physical examination. She was clinically diagnosed with acute cholecystitis and underwent cholecystectomy. Gross examination showed a 5-cm exophytic mass at the gallbladder fundus. Histopathologic examination of the mass showed an infiltrating squamous cell carcinoma and an adjacent high-grade neuroendocrine carcinoma; each of these two components composed more than 30% of the neoplasm and infiltrated into the perimuscular connective tissue with no serosal involvement. Additionally, a superficial adenocarcinoma component was also seen composing 10% of the neoplasm. The squamous cell carcinoma showed moderate differentiation with areas of keratinization; it was positive for Ck7, p40, and p63. The neuroendocrine carcinoma showed areas of geographic necrosis, and the cells had inconspicuous nucleoli and granular chromatin, with numerous mitotic figures; it was positive for synaptophysin and chromogranin. The adenocarcinoma showed gland formation with mucicarmine stain, highlighting the mucin within the neoplastic cells; it was positive for Ck7 but negative for p40. Subsequently, the patient underwent resection of the liver bed, which was negative for metastasis, and was then referred for chemotherapy. Conclusion Our review of the literature revealed seven documented cases of three-component gallbladder neuroendocrine neoplasms. Generally, patients with these tumors have a poor prognosis, and due to their rarity, no specific treatment guidelines have yet been established. It has been suggested that a multipotent common stem cell is the origin of these tumors.

Abstract #788: A Case of Metastatic Calcitonin-Secreting Nonthyroidal Neuroendocrine Carcinoma

2005 ◽  
Vol 11 ◽  
pp. 75-76
Author(s):  
Shirin Haddady ◽  
Alan Perry Farwell ◽  
Ashraf Khan
Keyword(s):  
Neuroendocrine Carcinoma

Neuroendocrine carcinoma arising in the sella: Diagnosis and treatment

2013 ◽  
Vol 121 (03) ◽  
Author(s):  
CHM Jaspers ◽  
R Salbeck ◽  
C Kahl ◽  
V Hans ◽  
G Berding ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Diagnosis And Treatment
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