scholarly journals A Case of Cecal Carcinoma Involving Isolated Metastatic Recurrence in a Right Obturator Lymph Node

Author(s):  
Hiroyuki TAKATORI ◽  
Kouki MAEDA ◽  
Keiichirou UCHIKURA ◽  
Kensuke NURUKI ◽  
Jouji WAKIMOTO
2017 ◽  
Vol 108 (4) ◽  
pp. 229-233
Author(s):  
Ryo Amakawa ◽  
Jun Akatsuka ◽  
Yasutomo Suzuki ◽  
Tsutomu Hamasaki ◽  
Go Kimura ◽  
...  

2019 ◽  
pp. 1-8 ◽  
Author(s):  
Ajay Gogia ◽  
S. V. Suryanarayana Deo ◽  
Dayanand Sharma ◽  
Rakesh K. Phulia ◽  
Sanjay Thulkar ◽  
...  

PURPOSE Biomarker—estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2/ neu) —discordance plays an essential role in the management and prognosis of patients with metastatic breast cancer. Rates of discordance have been previously reported around 12% to 35%, 30% to 50%, and 5% to 15%, respectively, in Western literature. Data are sparse regarding the same from developing countries, such as India. METHODS We performed an ambispective review of paired biomarker status in patients with breast cancer—stage I, II, and III as per American Joint Committee on Cancer, 7th edition—who developed metastasis at recurrence (N = 103 patients). Biomarker status and clinical and radiologic parameters were documented at baseline and subsequent follow-up. RESULTS Discordance was present in 21.3% for ER, 29.1% for PR, and 15.5% for HER2/ neu receptor. In our cohort, 7.8% had positive to negative ER and 13.6% negative to positive. Whereas 21.4% had positive to negative PR, 7.8% had negative to positive PR. Approximately 6.8% had positive to negative HER2/ neu receptor and 8.7% negative to positive. In our cohort, 41 patients (40%) had single-site metastasis—bone, 15.5%; lung, 11.7%; nonregional lymph node, 7.8%; liver, 3.9%; and brain, 0.97%. More than one site of metastasis was present in 62 patients (60%). The most common sites of metastasis were visceral—lung and liver—followed by bone, nonregional lymph node, skin, and brain. CONCLUSION The current study demonstrated that metastatic disease evolution in breast cancer is characterized by change in the tumor biology, which leads to discordance in receptor status. Repeat biomarker studies at metastatic recurrence is warranted, especially if treatment plans include hormone and targeted therapy.


2007 ◽  
Vol 57 (7) ◽  
pp. 454-457 ◽  
Author(s):  
Katia Ramos Moreira Leite ◽  
Alvaro Sadek Sarkis ◽  
Luiz Heraldo Camara-Lopes

2019 ◽  
Vol 72 (8) ◽  
pp. 509-515
Author(s):  
Haruka Oi ◽  
Takashi Okuyama ◽  
Shinichi Sameshima ◽  
Emiko Takeshita ◽  
Masatoshi Oya ◽  
...  

2007 ◽  
Vol 40 (4) ◽  
pp. 491-496 ◽  
Author(s):  
Eiji Yamada ◽  
Akira Mori ◽  
Satoshi Nagayama ◽  
Tamaki Okamoto ◽  
Takashi Koyama ◽  
...  

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