scholarly journals A Case of Successful Subtotal Colectomy for Hemorrhagic Colitis Caused by Enterohemorrhagic Escherichia Coli O-157 Infection

Author(s):  
Shunsuke HAMASAKI ◽  
Yujiro MURATA ◽  
Michiya BANDO ◽  
Masaki MORI ◽  
Yuji SATO
2002 ◽  
Vol 60 (2) ◽  
pp. 66-67
Author(s):  
Jun Mitsuhashi ◽  
Masahiro Igarashi ◽  
Shigeru Adachi ◽  
Shigeru Yoshizawa ◽  
Miwa Sata ◽  
...  

1997 ◽  
Vol 50 (0) ◽  
pp. 292-293
Author(s):  
Yasuharu Yamaguchi ◽  
Toshiyuki Hashimoto ◽  
Miki Miura ◽  
Genichi Koyama ◽  
Taro Yamato ◽  
...  

2000 ◽  
Vol 56 (2) ◽  
pp. 88-89
Author(s):  
Chiyuki Shikano ◽  
Hideaki Suzuki ◽  
Tetsuo Isozaki ◽  
Yasutoshi Mitsui ◽  
Harunobu Kawamura ◽  
...  

1989 ◽  
Vol 2 (1) ◽  
pp. 15-38 ◽  
Author(s):  
M A Karmali

Verocytotoxin (VT)-producing Escherichia coli (VTEC) are a newly recognized group of enteric pathogens which are increasingly being recognized as common causes of diarrhea in some geographic settings. Outbreak studies indicate that most patients with VTEC infection develop mild uncomplicated diarrhea. However, a significant risk of two serious and potentially life-threatening complications, hemorrhagic colitis and the hemolytic uremic syndrome, makes VTEC infection a public health problem of serious concern. The main reservoirs of VTEC appear to be the intestinal tracts of animals, and foods of animal (especially bovine) origin are probably the principal sources for human infection. The term VT refers to a family of subunit exotoxins with high biological activity. Individual VTEC strains elaborate one or both of at least two serologically distinct, bacteriophage-mediated VTs (VT1 and VT2) which are closely related to Shiga toxin and are thus also referred to as Shiga-like toxins. The holotoxins bind to cells, via their B subunits, to a specific receptor which is probably the glycolipid, globotriosyl ceramide (Gb3). Binding is followed by internalization of the A subunit, which, after it is proteolytically nicked and reduced to the A1 fragment, inhibits protein synthesis in mammalian cells by inactivating 60S ribosomal subunits through selective structural modification of 28S ribosomal ribonucleic acid. The mechanism of VTEC diarrhea is still controversial, and the relative roles of locally acting VT and "attaching and effacing adherence" of VTEC to the mucosa have yet to be resolved. There is increasing evidence that hemolytic uremic syndrome and possibly hemorrhagic colitis result from the systemic action of VT on vascular endothelial cells. The role of antitoxic immunity in preventing the systemic complications of VTEC infection is being explored. Antibiotics appear to be contraindicated in the treatment of VTEC infection. The most common VTEC serotype associated with human disease is O157:H7, but over 50 different VT-positive O:H serotypes have now been identified. The best strategies for diagnosing human VTEC infection include testing for the presence of free VT in fecal filtrates and examining fecal cultures for VTEC by means of deoxyribonucleic acid probes that specify genes encoding VT1 and VT2. Both methods are currently confined to specialized laboratories and await commercial development for wider use. In the meantime, most laboratories should continue to screen for the most common human VTEC serotype, O157:H7, using a sorbitol-containing MacConkey medium.


2013 ◽  
Vol 7 (5) ◽  
pp. 361-366 ◽  
Author(s):  
Gomoacute łka Pawlicka M ◽  
Uradziński J ◽  
Migowska Calik A ◽  
Pastuszczak Frąk M

1999 ◽  
Vol 53 (0) ◽  
pp. 182-183
Author(s):  
Jun Unno ◽  
Yoshiyuki Tawa ◽  
Tetsutaka Sano ◽  
Sakiko Arai ◽  
Hisashi Okuyama ◽  
...  
Keyword(s):  
E Coli ◽  

Sign in / Sign up

Export Citation Format

Share Document