scholarly journals The Efficacy of Micrometastasis Detection in Sentinel Lymph Nodes by Using a Combination of the ICG Fluorescence Navigation Method and the OSNA Method in Breast Cancer

2015 ◽  
Vol 76 (10) ◽  
pp. 2367-2372
Author(s):  
Hajime MATSUMOTO ◽  
Kazuhiko YAMAGAMI ◽  
Teruyuki DEAI ◽  
Takashi HASHIMOTO ◽  
Shuichi MONZAWA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Sentinel Lymph Nodes ◽  
Osna Method ◽  
Navigation Method

scholarly journals Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Yanfeng Dai ◽  
Xiang Yu ◽  
Jianshuang Wei ◽  
Fanxin Zeng ◽  
Yiran Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Scavenger Receptor ◽  
Intradermal Injection ◽  
Sentinel Lymph Nodes ◽  
Breast Cancer Surgery ◽  
Photoacoustic Microscopy ◽  
Dual Targeting ◽  
Scavenger Receptor Class ◽  
Distinct Distribution

Abstract Detection of sentinel lymph nodes (SLNs) is critical to guide the treatment of breast cancer. However, distinguishing metastatic SLNs from normal and inflamed lymph nodes (LNs) during surgical resection remains a challenge. Here, we report a CD44 and scavenger receptor class B1 dual-targeting hyaluronic acid nanoparticle (5K-HA-HPPS) loaded with the near-infra-red fluorescent dye DiR-BOA for SLN imaging in breast cancer. The small sized (~40 nm) self-assembled 5K-HA-HPPSs accumulated rapidly in the SLNs after intradermal injection. Compared with normal popliteal LNs (N-LN), there were ~3.2-fold and ~2.4-fold increases in fluorescence intensity in tumour metastatic SLNs (T-MLN) and inflamed LNs (Inf-LN), respectively, 6 h after nanoparticle inoculation. More importantly, photoacoustic microscopy (PAM) of 5K-HA-HPPS showed a significantly distinct distribution in T-MLN compared with N-LN and Inf-LN. Signals were mainly distributed at the centre of T-MLN but at the periphery of N-LN and Inf-LN. The ratio of PA intensity (R) at the centre of the LNs compared with that at the periphery was 5.93 ± 0.75 for T-MLNs of the 5K-HA-HPPS group, which was much higher than that for the Inf-LNs (R = 0.2 ± 0.07) and N-LNs (R = 0.45 ± 0.09). These results suggest that 5K-HA-HPPS injection combined with PAM provides a powerful tool for distinguishing metastatic SLNs from pLNs and inflamed LNs, thus guiding the removal of SLNs during breast cancer surgery.

Additional axillary metastases and stage migration in breast cancer patients with micrometastases or submicrometastases in sentinel lymph nodes

Cancer ◽  
2006 ◽  
Vol 107 (3) ◽  
pp. 467-471 ◽  
Author(s):  
Maartje C. van Rijk ◽  
Johannes L. Peterse ◽  
Omgo E. Nieweg ◽  
Hester S. A. Oldenburg ◽  
Emiel J. Th. Rutgers ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Sentinel Lymph Nodes ◽  
Stage Migration ◽  
Breast Cancer Patients ◽  
Axillary Metastases
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