scholarly journals Small Bowel Cancer Associated with Lynch Syndrome—Two Case Reports and a Review of the Literature—

2015 ◽  
Vol 76 (9) ◽  
pp. 2225-2230
Author(s):  
Hirokazu KODAMA ◽  
Hiromichi SONODA ◽  
Tomoharu SHIMIZU ◽  
Hiroyuki OHTA ◽  
Eiji MEKATA ◽  
...  
Keyword(s):  
Small Bowel ◽  
Lynch Syndrome ◽  
Case Reports ◽  
Bowel Cancer ◽  
Review Of The Literature ◽  
Small Bowel Cancer

scholarly journals Incidence of small bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy

2017 ◽  
Vol 05 (07) ◽  
pp. E622-E626 ◽  
Author(s):  
Jasmijn Haanstra ◽  
Abdul Al-Toma ◽  
Evelien Dekker ◽  
Steven Vanhoutvin ◽  
Fokko Nagengast ◽  
...  
Keyword(s):  
Small Bowel ◽  
Early Detection ◽  
Lynch Syndrome ◽  
Prospective Study ◽  
Capsule Endoscopy ◽  
Bowel Cancer ◽  
Video Capsule Endoscopy ◽  
Small Bowel Cancer ◽  
Increased Risk ◽  
Malignant Lesions

Abstract Background and study aims Lynch syndrome (LS) patients have an increased risk of small bowel cancer. The question is whether surveillance will lead to early detection of (pre)malignant lesions. We recently reported on prevalence of small bowel neoplasia (SBN) in LS patients as assessed by video capsule endoscopy (VCE). The aim of this prospective study was to determine the incidence of SBN. Patients and methods Asymptomatic LS patients who underwent a VCE were invited to undergo a second VCE procedure 2 years later. If abnormalities or polypoid lesions larger than 1 cm were detected, subsequent endoscopic procedures were performed. Results A total of 155 (78 %) of the initial 200 patients underwent a second VCE procedure after a mean of 2.2 (range 1 – 6) years. In 17 of the 155 (11 %) patients possibly significant lesions were detected, which required further investigation by means of gastroduodenoscopy (n = 8) or balloon-assisted endoscopy (n = 9). These procedures revealed no SBN. Conclusion No SBN was found after 2 years. Surveillance of the small bowel by VCE does not seem to be warranted in asymptomatic LS patients. This study was registered in the Clinical Trials.gov registry with identifier NCT00898768.

scholarly journals Prevalence of mismatch repair deficiency and Lynch syndrome in a cohort of unselected small bowel adenocarcinomas

2020 ◽  
pp. jclinpath-2020-207040
Author(s):  
Manon Suerink ◽  
Gül Kilinç ◽  
Diantha Terlouw ◽  
Hristina Hristova ◽  
Lily Sensuk ◽  
...  
Keyword(s):  
Small Bowel ◽  
Lynch Syndrome ◽  
Mismatch Repair ◽  
Promoter Hypermethylation ◽  
Bowel Cancer ◽  
Family Management ◽  
Small Bowel Cancer ◽  
Repair Deficiency ◽  
Mmr Deficiency ◽  
Mmr Proteins

AimsPrevious estimates of the prevalence of mismatch repair (MMR) deficiency and Lynch syndrome in small bowel cancer have varied widely. The aim of this study was to establish the prevalence of MMR deficiency and Lynch syndrome in a large group of small bowel adenocarcinomas.MethodsTo this end, a total of 400 small bowel adenocarcinomas (332 resections, 68 biopsies) were collected through the Dutch nationwide registry of histopathology and cytopathology (Pathologisch-Anatomisch Landelijk Geautomatiseerd Archief (PALGA)). No preselection criteria, such as family history, were applied, thus avoiding (ascertainment) bias. MMR deficiency status was determined by immunohistochemical staining of MMR proteins, supplemented by MLH1 promoter hypermethylation analysis and next generation sequencing of the MMR genes.ResultsMMR deficiency was observed in 22.3% of resected and 4.4% of biopsied small bowel carcinomas. Prevalence of Lynch syndrome was 6.2% in resections and 0.0% in biopsy samples. Patients with Lynch syndrome-associated small bowel cancer were significantly younger at the time of diagnosis than patients with MMR-proficient and sporadic MMR-deficient cancers (mean age of 54.6 years vs 66.6 years and 68.8 years, respectively, p<0.000).ConclusionsThe prevalence of MMR deficiency and Lynch syndrome in resected small bowel adenocarcinomas is at least comparable to prevalence in colorectal cancers, a finding relevant both for treatment (immunotherapy) and family management. We recommend that all small bowel adenocarcinomas should be screened for MMR deficiency.

Small bowel cancer risk in Lynch syndrome

Gut ◽  
2008 ◽  
Vol 57 (11) ◽  
pp. 1629-1630 ◽  
Author(s):  
K. Schulmann ◽  
C. Engel ◽  
P. Propping ◽  
W. Schmiegel
Keyword(s):  
Small Bowel ◽  
Cancer Risk ◽  
Lynch Syndrome ◽  
Bowel Cancer ◽  
Small Bowel Cancer

Small-bowel cancer in Lynch syndrome: is it time for surveillance?

2008 ◽  
Vol 9 (9) ◽  
pp. 901-905 ◽  
Author(s):  
Jan J Koornstra ◽  
Jan H Kleibeuker ◽  
Hans FA Vasen
Keyword(s):  
Small Bowel ◽  
Lynch Syndrome ◽  
Bowel Cancer ◽  
Small Bowel Cancer

scholarly journals A novel MLH1 mutation in a Japanese family with Lynch syndrome associated with small bowel cancer

2018 ◽  
Vol 5 (1) ◽  
Author(s):  
Yoshika Akizawa ◽  
Toshiyuki Yamamoto ◽  
Kazuo Tamura ◽  
Toshiyuki Kanno ◽  
Nobuko Takahashi ◽  
...  
Keyword(s):  
Small Bowel ◽  
Lynch Syndrome ◽  
Bowel Cancer ◽  
Japanese Family ◽  
Small Bowel Cancer

scholarly journals Management of Advanced Small Bowel Cancer

2018 ◽  
Vol 19 (12) ◽  
Author(s):  
Alberto Puccini ◽  
Francesca Battaglin ◽  
Heinz-Josef Lenz
Keyword(s):  
Small Bowel ◽  
Bowel Cancer ◽  
Small Bowel Cancer

Small bowel adenocarcinoma: Case reports and review of the literature

2021 ◽  
Author(s):  
John Manley ◽  
Yousef Ibrahim ◽  
James Ansell ◽  
Hani Alastal ◽  
Ashraf Rasheed
Keyword(s):  
Small Bowel ◽  
Case Reports ◽  
Small Bowel Adenocarcinoma ◽  
Review Of The Literature
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