scholarly journals Therapeutic Outcomes of Simultaneous Resection of Colorectal Cancer and Synchronous Hepatic Metastasis

2014 ◽  
Vol 75 (8) ◽  
pp. 2096-2104
Author(s):  
Koji NUMATA ◽  
Manabu SHIOZAWA ◽  
Soichiro MORINAGA ◽  
Yasushi RINO ◽  
Munetaka MASUDA ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hepatic Metastasis ◽  
Simultaneous Resection ◽  
Therapeutic Outcomes

A Comparative Study of Operated and Non-operated Groups in Patients with Hepatic Metastasis from Colorectal Cancer

2007 ◽  
Vol 23 (6) ◽  
pp. 477
Author(s):  
Sang Chul Yun ◽  
Hyung Chul Kim ◽  
Chong Woo Chu ◽  
Eung Jin Shin ◽  
Moo Jun Baek ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Comparative Study ◽  
Hepatic Metastasis

scholarly journals Simultaneous resection for colorectal cancer with synchronous liver metastases is a safe procedure: Outcomes at a single center in Turkey

2017 ◽  
Vol 11 (2) ◽  
pp. 235-242
Author(s):  
Ender Dulundu ◽  
Wafi Attaallah ◽  
Metin Tilki ◽  
Cumhur Yegen ◽  
Safak Coskun ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Safe Procedure ◽  
Single Center ◽  
Synchronous Liver Metastases ◽  
Simultaneous Resection

scholarly journals Comparison of Radiofrequency Ablation and Resection for Hepatic Metastasis from Colorectal Cancer

2012 ◽  
Vol 59 (3) ◽  
pp. 218 ◽  
Author(s):  
Kwan Ho Lee ◽  
Hyung Ook Kim ◽  
Chang Hak Yoo ◽  
Byung Ho Son ◽  
Yong Lai Park ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Radiofrequency Ablation ◽  
Hepatic Metastasis

scholarly journals Noninvasive evaluation of 18F-FDG/18F-FMISO-based Micro PET in monitoring hepatic metastasis of colorectal cancer

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Mingyu Zhang ◽  
Huijie Jiang ◽  
Rongjun Zhang ◽  
Hailong Xu ◽  
Hao Jiang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hepatic Metastasis ◽  
Noninvasive Evaluation ◽  
18F Fdg

scholarly journals Higher titer hepatitis B core antibody predicts a higher risk of liver metastases and worse survival in patients with colorectal cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Ziyao Li ◽  
Shaofei Li ◽  
Hangbo Tao ◽  
Yixiang Zhan ◽  
Kemin Ni ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Hepatitis B ◽  
Liver Metastases ◽  
Cancer Patients ◽  
Hepatic Metastasis ◽  
High Titer ◽  
Poor Overall Survival ◽  
Free Survival ◽  
Colorectal Cancer Patients

Abstract Background There have been controversial voices on if hepatitis B virus infection decreases the risk of colorectal liver metastases or not. This study aims to the find the association between HBV infection and postoperative survival of colorectal cancer and the risk of liver metastases in colorectal cancer patients. Methods Patients who underwent curative surgical resection for colorectal cancer between January 2011 and December 2012 were included. Patients were grouped according to anti-HBc. Differences in overall survival, time to progress, and hepatic metastasis-free survival between groups and significant predictors were analyzed. Results Three hundred twenty-seven colorectal cancer patients were comprised of 202 anti-HBc negative cases and 125 anti-HBc positive cases, and anti-HBc positive cases were further divided into high-titer anti-HBc group (39) and low-titer anti-HBc group (86). The high-titer anti-HBc group had significantly worse overall survival (5-Yr, 65.45% vs. 80.06%; P < .001), time to progress (5-Yr, 44.26% vs. 84.73%; P < .001), and hepatic metastasis-free survival (5-Yr, 82.44% vs. 94.58%; P = .029) than the low-titer group. Multivariate model showed anti-HBc ≥ 8.8 S/CO was correlated with poor overall survival (HR, 3.510; 95% CI, 1.718–7.17; P < .001), time to progress (HR, 5.747; 95% CI, 2.789–11.842; P < .001), and hepatic metastasis-free survival (HR, 3.754; 95% CI, 1.054–13.369; P = .041) in the anti-HBc positive cases. Conclusions Higher titer anti-HBc predicts a potential higher risk of liver metastases and a worse survival in anti-HBc positive colorectal cancer patients.

scholarly journals CircRNA circ_0124554 blocked the ubiquitination of AKT promoting the skip lymphovascular invasion on hepatic metastasis in colorectal cancer

2020 ◽  
Author(s):  
Junwei Tang ◽  
Yifei Feng ◽  
Yuanjian Huang ◽  
Ziwei Xu ◽  
Dongsheng Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Liver Metastasis ◽  
Hepatic Metastasis ◽  
Vascular Invasion ◽  
Synchronous Liver Metastasis ◽  
Node Negative ◽  
Common Cancer ◽  
Tumor Tissues ◽  
Colorectal Cancer Patients

Abstract Background Colorectal cancer (CRC) is the fourth most common cancer in men and the third most common cancer in women worldwide. The incidence and mortality of CRC was increasing rapidly in China. Lymph node-negative colorectal cancer patients with synchronous liver metastasis (LNLM1) was defined as “skip” lymph vascular invasion on hepatic metastasis, who presenting poor prognosis. We aiming to investigate the potential mechanism for the “skip” lymph vascular invasion on hepatic metastasis in colorectal cancer. Methods The microarray was applied for screening the transcription landscape of circRNA in lymph node negative CRC patients with synchronous liver metastasis (LNLM1) or without liver metastasis (LNLM0). The gain- and loss-of-function experiments was conducted in CRC cell lines and animal models. The RNA pull-down, RNA immunoprecipitation n was further employed in exploring the detailed mechanism of circRNA and associated target genes. Results We identified the aberrant increased circRNA circ_0124554 (also entitled as circ-LNLM) in tumor tissues of LNLM1 patients comparing with either the tumor tissues of LNLM0 or adjacent tissues of LNLM1. Circ-LNLM1 expression was highly corrected with liver metastasis and vascular invasion. Ectopic expression of cytoplasmic located circ-LNLM could promote invasion of CRC cells and induced the liver metastasis in animal models through the direct binding with AKT. The phosphorylation of AKT (T308/S473) was activated due to the blocked ubiquitination site of Lys in 0-52aa peptide of circ-LNLM. Endogenous plasma expression of circ-LNLM induced poor prognosis of LNLM1 and could distinguish LNLM1 patients from LNLM0. Conclusions The circ-LNLM blocked the ubiquitination of AKT could promote the early metastasis especially for the lymph node-negative colorectal cancer patients with synchronous liver metastasis. The circ-LNLM might be prognosis and diagnosis biomarker for LNLM1 patients.

scholarly journals Hepatic metastasis from colorectal cancer, seven procedures and five recurrences, when to stop? A Case report

10.19082/7364 ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 7364-7369
Author(s):  
Manar Mutlag Alharthi ◽  
Anwar Saeed Alzahrani ◽  
Shaikhah A-Jumaiah ◽  
Mohammed Saad Alqahtani
Keyword(s):  
Colorectal Cancer ◽  
Case Report ◽  
Hepatic Metastasis
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