A CASE OF FLUMINANT AMEBIC COLITIS WITH A REFRACTORY VESICORECTAL FISTULA DDURING SYSTEMIC CHEMOTHERAPY FOR LUNG CANCER

2011 ◽  
Vol 72 (3) ◽  
pp. 727-731
Author(s):  
Ichiro TAMAKI ◽  
Dai MANAKA ◽  
Shinji BABA
Keyword(s):  
Lung Cancer ◽  
Systemic Chemotherapy ◽  
Amebic Colitis

scholarly journals P1.06-019 The Possibility of the Additional Local Therapy to Systemic Chemotherapy in Advanced Lung Cancer Cases with Multiple Metastases

2017 ◽  
Vol 12 (1) ◽  
pp. S676-S677
Author(s):  
Takeshi Honda ◽  
Hirofumi Uehara ◽  
Maika Natsume ◽  
Yoko Fukasawa ◽  
Takahiko Sakamoto ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Systemic Chemotherapy ◽  
Local Therapy ◽  
Advanced Lung Cancer ◽  
Multiple Metastases

Measurable or assessable disease in lung cancer trials: does it matter?

1994 ◽  
Vol 12 (12) ◽  
pp. 2677-2681 ◽  
Author(s):  
J R Jett ◽  
J Q Su ◽  
J E Krook ◽  
R M Goldberg ◽  
J W Kugler
Keyword(s):  
Lung Cancer ◽  
Clinical Response ◽  
Systemic Chemotherapy ◽  
Disease Status ◽  
Response Rates ◽  
Phase Iii ◽  
Time To Progression ◽  
Group Setting ◽  
Measurable Disease ◽  
Nsclc Patients

PURPOSE The goals of this study were to analyze and compare the major clinical response rates and survival of patients with either measurable or assessable disease status to treatment with systemic chemotherapy. PATIENTS AND METHODS All patients had stage IIIB or IV non-small-cell lung cancer (NSCLC) and were enrolled onto three consecutive phase III clinical trials. Patients were stratified by disease status (measurable or assessable) before randomization to systemic chemotherapy. The three trials were conducted in the setting of a multicenter cooperative oncology group. Composite data were obtained for the three trials. Major clinical responses, time to progression, and survival were analyzed and compared in patients with measurable or assessable disease using standard statistical methods. RESULTS Four hundred twenty-six patients were enrolled onto the three trials from June 1981 through August 1990. Measurable disease was present in 236 patients (55%) and assessable disease in 190 (45%). Each study was well balanced for the number of patients with measurable or assessable disease on either treatment regimen. A major clinical response was observed in 71 patients with measurable disease (30%; 95% confidence interval [CI], 24 to 36). Forty patients with assessable disease responded to treatment (21%; 95% CI, 16 to 28) (P = .04). The time to progression for all patients (P = .23) and for responders only (P = .10) was not significantly different based on disease status. Overall survival and survival of responders only was not significantly different, but patients with assessable disease tended to do better. Using multivariate analysis, sex and disease status had a borderline influence on the major response rate (P = .05). Performance score (PS) was the only factor that was significantly correlated with survival. CONCLUSION NSCLC patients with assessable disease have major clinical response rates, time to progression, and survival that are similar to those of NSCLC patients with measurable disease. This study supports the inclusion of patients with assessable-disease lung cancer in both phase II and III trials conducted in the cooperative group setting.

scholarly journals Paraneoplastic Limbic Encephalitis Complicated with Small Cell Lung Cancer at the Time of Recurrence

2019 ◽  
Vol 12 (2) ◽  
pp. 466-472
Author(s):  
Hironori Sadamatsu ◽  
Yuki Kurihara ◽  
Koichiro Takahashi ◽  
Kazutoshi Komiya ◽  
Shinsuke Ogusu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Systemic Chemotherapy ◽  
Limbic Encephalitis ◽  
Brain Magnetic Resonance Imaging ◽  
Small Cell ◽  
High Dose ◽  
Small Cell Lung ◽  
Paraneoplastic Limbic Encephalitis

Paraneoplastic limbic encephalitis (PLE) is a rare neurologic disorder that can complicate various malignancies, including lung cancer. PLE is most frequently found the initial presentation of lung cancer. In this study, we reported the case of a 74-year-old Japanese woman who developed PLE after partial remission of small cell lung cancer (SCLC) by first-line systemic chemotherapy. Brain magnetic resonance imaging showed no metastatic tumor or cerebrovascular disease. Anti-glutamic acid decarboxylase (GAD) and anti-amphiphysin antibodies were detected in her serum. She was diagnosed as having PLE related to the recurrence of SCLC and received high-dose glucocorticoid, and sequentially systemic chemotherapy with amrubicin. Unfortunately, these treatments did not improve her disease progression and she died 4 months later. Although PLE rarely occurs at the time of SCLC recurrence, physicians should pay attention to PLE onset even after chemotherapy.

Patterns of systemic chemotherapy in resectable non-small cell lung cancer

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 7590-7590
Author(s):  
S. Dubey ◽  
R. Su ◽  
G. Nalbandian ◽  
J. Hwang ◽  
T. M. Jahan
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Systemic Chemotherapy ◽  
Small Cell ◽  
Small Cell Lung

Non-Small Cell Lung Cancer: From Cytotoxic Systemic Chemotherapy to Molecularly Targeted Therapy

2004 ◽  
Vol 4 (3) ◽  
pp. 231-245 ◽  
Author(s):  
Alfredo Cesario ◽  
Sonya Trombino ◽  
Domenico Galetta ◽  
Stefano Margaritora ◽  
Carmelina Murolo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Targeted Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Systemic Chemotherapy ◽  
Small Cell ◽  
Small Cell Lung ◽  
Molecularly Targeted Therapy
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