scholarly journals A CASE OF RECTAL CANCER WITH A RECURRENCE IN THE ANAL CANAL 9CM FROM THE PRIMARY LESION

2011 ◽  
Vol 72 (2) ◽  
pp. 434-437
Author(s):  
Shinya OKUMURA ◽  
Suguru HASEGAWA ◽  
Satoshi YAMANOKUCHI ◽  
Yoshito ASAO ◽  
Hiroaki FURUYAMA ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Anal Canal ◽  
Primary Lesion

A new ultimate anus-preserving operation for extremely low rectal cancer and for anal canal cancer

2003 ◽  
Vol 7 (3) ◽  
pp. 203-206 ◽  
Author(s):  
K. Shirouzu ◽  
Y. Ogata ◽  
Y. Araki ◽  
Y. Kishimoto ◽  
Y. Sato
Keyword(s):  
Rectal Cancer ◽  
Anal Canal ◽  
Low Rectal Cancer ◽  
Anal Canal Cancer

scholarly journals Risk factors and therapeutic significance for inguinal lymph node metastasis in advanced lower rectal cancer.

2019 ◽  
Vol 5 (suppl) ◽  
pp. 120-120
Author(s):  
Hiroaki Nozawa ◽  
Hiroshi Shiratori ◽  
Kazushige Kawai ◽  
Keisuke Hata ◽  
Toshiaki Tanaka ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Anal Canal ◽  
Inguinal Lymph Node ◽  
Dentate Line ◽  
Lower Rectal Cancer ◽  
Inguinal Lymph Node Metastasis ◽  
Node Metastasis ◽  
Therapeutic Value

120 Background: Which patients with lower rectal cancer are at risk of inguinal lymph node metastasis (ILNM) and how to treat ILNM remain unclear. This study aimed to clarify the predictors of ILNM and clinical significance of treatment for ILNM. Methods: Consecutive patients with rectal adenocarcinoma invading the anal canal who underwent curative surgery between 2003 and 2019 at a single institution were retrospectively reviewed. The pathological nodal involvement in mesorectal, lateral pelvic or inguinal lymph nodes (ILN) at the time of rectal surgery and of later onset were collectively defined as final nodal metastasis (f-LNM) in this study. Factors associated with f-LNM were analyzed. Moreover, the ‘modified therapeutic value index’ defined by the 5-year overall survival rate of patients treated against f-LNM multiplied by their frequency was calculated for each lymph node area. Results: A total of 145 patients were enrolled, among whom16 patients developed ILNM. For predicting f-ILNM, the cutoff 8.5 mm of ILN diameter gave area under the curve of 0.889. Dentate line involvement and ILN larger than a simplified cutoff of 8 mm were independently associated with the development of ILNM (odds ratio: 33.4 and 11.9, respectively). The modified therapeutic value indice of inguinal, lateral pelvic and mesorectal LNs in the entire population were 6.1, 8.2 and 20.3 points, respectively. In patients with dentate line invaded by cancer, they were 11.7, 5.8 and 16.2 points, respectively. Moreover, the index of ILN was 21.1 points when confined to patients with ILN larger than 8 mm. Conclusions: Dentate line involvement and ILN larger than 8 mm were predictive of developing ILNM in patients with rectal cancer invading the anal canal. Treatment of ILNM may be recommended for patients manifesting the above predictors, given the significant therapeutic outcomes.

Predictors of gastrointestinal toxicity during pelvic radiotherapy.

2013 ◽  
Vol 31 (4_suppl) ◽  
pp. 472-472
Author(s):  
T. Jonathan Yang ◽  
Jung Hun Oh ◽  
Christina Son ◽  
Aditya Apte ◽  
Joseph O. Deasy ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Anal Canal ◽  
Treatment Plan ◽  
Univariate Analysis ◽  
Intensity Modulated Radiotherapy ◽  
Female Gender ◽  
Relative Reduction ◽  
Pelvic Radiotherapy ◽  
Dose Volume ◽  
Gi Toxicity

472 Background: To identify clinical and dosimetric factors associated with acute gastrointestinal (GI) toxicities due to pelvic radiotherapy (PRT) in patients with rectal cancer. Methods: We analyzed 177 consecutive rectal cancer patients treated between 2007-2010. Clinical information including age, gender, stage, chemotherapy, and weekly proctitis and diarrhea grade (CTCAE 3.0) during PRT were obtained. The bowel, rectum, and anal canal were contoured on CT treatment planning images. Doses to GI structures were calculated using the original treatment plan, and dose-volume parameters were extracted for modeling using CERR software. Logistic regression models were used to test the association between GI toxicity grade and predictors. Results: The mean age was 59; 76 (43%) patients were women; 166 (94%) received concurrent 5-FU based chemotherapy. Over half (56%) were treated with intensity modulated radiotherapy (IMRT), 44% were treated with 3D conformal RT (3DCRT). Grade 2+ proctitis and diarrhea were seen in 57 (32%) and 44 (25%) patients, respectively. On univariate analysis, age inversely predicts for Grade 2+ proctitis (Rs=-0.22, p=0.009). 3DCRT (Rs=0.27, p=0.001) and female gender (Rs=0.28, p=0.0008) predict for Grade 2+ diarrhea. On multivariate analysis, the normal tissue complication model including volume of anal canal receiving >15Gy, anal canal minimal dose, and age was most predictive of Grade 2+ proctitis (AUC=0.67, Rs=0.25, p<0.001). The model including bowel volume receiving 45Gy, female gender, and use of 3DCRT was highly predictive of Grade 2+ diarrhea (AUC=0.76, Rs=0.35, p<0.001). Patients treated with IMRT had significantly less bowel volume receiving ≥ 45Gy compared to 3DCRT (V45Gy=10.9% vs. 21.7%, p<0.0001). Conclusions: In this analysis of a large cohort of patients receiving PRT for rectal cancer, we identified clinical and dosimetric predictors of acute GI toxicity. Younger patients and women have higher rates of acute Grade 2+ proctitis and diarrhea, respectively. IMRT resulted in a 50% relative reduction in bowel volume receiving 45Gy and a lower risk for clinically significant diarrhea. Dose-volume constraints using these parameters should be considered, particularly in higher risk patients.

scholarly journals A Case of Residual Rectal Cancer for Ulcerative Colitis Five Years after Ileo-Anal Canal Anastomosis

2016 ◽  
Vol 69 (7) ◽  
pp. 397-403
Author(s):  
Shingo Kawano ◽  
Yurika Makino ◽  
Shunsuke Motegi ◽  
Kumpei Honjo ◽  
Hisashi Ro ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Rectal Cancer ◽  
Anal Canal

scholarly journals Height of Rectal Cancer: A Comparison between Rectoscopic and Different MRI Measurements

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
U. I. Attenberger ◽  
J. Winter ◽  
F. N. Harder ◽  
I. Burkholder ◽  
D. Dinter ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Anal Canal ◽  
Gold Standard ◽  
Anal Verge ◽  
Measurement Techniques ◽  
Primary Rectal Cancer ◽  
Height Determination ◽  
Lower Border ◽  
Straight Line ◽  
Mri Measurements

Purpose. To compare rigid rectoscopy with three different MRI measurement techniques for rectal cancer height determination, all starting at the anal verge, in order to evaluate whether MRI measurements starting from the anal verge could be an alternative to rigid rectoscopy. Moreover, potential cut-off values for MRI in categorizing tumor height measurements were evaluated. Methods. In this retrospective study, 106 patients (75 men, 31 female, mean age 64±11.59 years) with primary rectal cancer underwent rigid rectoscopy as well as MR imaging. Three different measurements (MRI1–3) in T2w sagittal scans were used to evaluate the exact distance from the anal verge (AV) to the distal ending of the tumor (MRI1: two unbowed lines, AV to the upper ending of the anal canal and upper ending of the anal canal to the lower border of the tumor; MRI2: one straight line from the AV to the lower boarder of the tumor; MRI3: a curved line beginning at the AV and following the course of the rectum wall ending at the lower border of the tumor). Furthermore, agreement between the gold standard rigid rectoscopy (UICC classification: low part, 0-6 cm; mid part, 6-12 cm; and high part, >12 cm) and each MRI measuring technique was analyzed. Results. Only a fair correlation in terms of individual measures between rectoscopy and all 3 MRI measurement techniques was shown. The proposed new cut-off values utilizing ROC analysis for the three different MRI beginning at the anal verge were low 0-7.7 cm, mid 7.7-13.3 cm, and high>13.3 cm (MRI1); low 0-7.4 cm, mid 7.4-11.2 cm, and high>11.2 cm (MRI2); and low 0-7.1 cm, mid 7.1-13.7 cm, and high>13.7 cm (MRI3). For MRI1 and MRI3, the agreement to the gold standard was substantial (r=0.66, r=0.67, respectively). Conclusion. This study illustrates that MRI1 and MRI3 measures can be interchangeably used as a valid method to determine tumor height compared to the gold standard rigid rectoscopy.

Sentinel lymph node in patients with rectal cancer invading the anal canal

2010 ◽  
Vol 14 (2) ◽  
pp. 133-139 ◽  
Author(s):  
D. C. Damin ◽  
G. C. Tolfo ◽  
M. A. Rosito ◽  
B. L. Spiro ◽  
L. M. Kliemann
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Anal Canal
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