scholarly journals PREDICTION OF PATHOLOGICAL RESPONSE TO PRIMARY SYSTEMIC CHEMOTHERAPY FOR BREAST CANCER

2011 ◽  
Vol 72 (11) ◽  
pp. 2759-2766
Author(s):  
Hiroyoshi MIURA ◽  
Yoshinori ITO ◽  
Yumi MIYAGI ◽  
Takuji IWASE ◽  
Rie HORII ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systemic Chemotherapy ◽  
Pathological Response ◽  
Primary Systemic Chemotherapy

Evaluation of early response to primary systemic chemotherapy in breast cancer patients by 18FDG PET: Preliminary findings from the Arianna Project 01

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10722-10722 ◽  
Author(s):  
C. Zamagni ◽  
S. Fanti ◽  
A. Bernardi ◽  
F. Sperandi ◽  
S. Quercia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Systemic Chemotherapy ◽  
Standardized Uptake Value ◽  
Breast Mri ◽  
Pathological Response ◽  
Primary Tumors ◽  
Tumour Regression Grade ◽  
Primary Systemic Chemotherapy ◽  
The Relationship

10722 Background: Pathological complete remission after primary systemic chemotherapy (PSC) for early breast cancer (BC) correlates with a better prognosis in terms of survival. The Arianna Project 01 was designed to study the relationship between clinical, hystological, biological, gene-expression profile characteristics and response to PSC in BC pts. Methods: Pts treated with 6 cycles of adriamycin 60 mg/m2 and paclitaxel 200 mg/m2 were evaluated at baseline and before each cycle by physical exam, 18FDG-PET, circulating tumor cells and bio-markers (serum EGFR, VEGF, UPA, plasma PAI-I and the circulating portion of HER2/neu receptor). At baseline and every other cycle mammography, ultrasound and breast MRI were also done. This preliminary report is focused on the correlation between PET monitoring and pathological response. Changes in tumoral 18FDG uptake, expressed as Standardized Uptake Value (SUV), were compared with the hystopathological response assessed according to Miller-Payne scale, which estimates the Tumour Regression Grade (TRG). Results: Up to now 12 pts (T > 2 cm) have been enrolled in the study and 9 completed PSC and were submitted to surgery. Baseline PET was abnormal in all pts (SUVmax range: 3.9–17.1). No cases of complete pathological remission have been observed so far. In 2 pts the TRG was grade 4 ( > 90% reduction of tumor cells), TRG was grade 3 (30 to 90% reduction) in 3 cases, grade 2 (minor loss of tumor cells) in 4 cases. After the 1st, the 2nd and the 3rd cycle of PSC the SUV decrease (Δ SUV) in primary tumors was ≥ 50%, ≥ 75% and ≥ 85% only in the two pts that at the end of PSC obtained a TRG grade 4 (see table ). Conclusions: Our preliminary results suggest that an early prediction of pathological response by PET is possible and the optimal timing to perform PET during PSC could be after 2 or 3 cycles. The study is still ongoing and the relationship between evaluation performed by PET and by mammography, ultrasound and breast MRI will be presented at the ASCO meeting. [Table: see text] No significant financial relationships to disclose.

scholarly journals Surgery after Primary Systemic Chemotherapy in Patients with Breast Cancer

Breast Care ◽  
2006 ◽  
Vol 1 (6) ◽  
pp. 358-361
Author(s):  
Wolfgang Eiermann ◽  
Beyhan Ataseven
Keyword(s):  
Breast Cancer ◽  
Systemic Chemotherapy ◽  
Primary Systemic Chemotherapy

scholarly journals P184 Differential pathologic response from primary systemic chemotherapy across breast cancer intrinsic subtypes

The Breast ◽  
2011 ◽  
Vol 20 ◽  
pp. S39-S40
Author(s):  
H. Jinno ◽  
S. Matsuda ◽  
M. Sakata ◽  
T. Hayashida ◽  
M. Takahashi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systemic Chemotherapy ◽  
Pathologic Response ◽  
Intrinsic Subtypes ◽  
Primary Systemic Chemotherapy

Tumor M2-Pk as predictive factor in primary systemic chemotherapy in breast cancer

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 891-891
Author(s):  
A. Thomas ◽  
T. Fischer ◽  
H.-J. Winzer ◽  
B. Wegner ◽  
S. Korlach ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Predictive Factor ◽  
Systemic Chemotherapy ◽  
Primary Systemic Chemotherapy

Primary systemic chemotherapy for operable breast cancer with docetaxel followed by cyclophosphamide, epirubicin, and fluorauracil (DOC-CEF)

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 11085-11085
Author(s):  
Y. Kikawa ◽  
Y. Masai ◽  
T. Hashimoto ◽  
Y. Nakamoto ◽  
H. Nishikawa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systemic Chemotherapy ◽  
Response Rate ◽  
Conservative Surgery ◽  
Breast Conserving Surgery ◽  
High Response Rate ◽  
High Response ◽  
Clinical Response Rate ◽  
Primary Systemic Chemotherapy ◽  
Sequential Administration

11085 Background: Primary systemic chemotherapy (PSC) for breast cancer has been considered to be useful controlling the micrometastasis and shown to increase the breast conserving surgery rate, result in similar survival rate as usual post-operative adjuvant chemotherapy. Recently, doxorubicin based regimen followed by taxan regimen in neoadjuvant chemotherapy has shown a high response rate and sequential administration is supposed to be important. However, taxan regimens sequentially followed by doxorubicin are not so common. The purpose of this study is to evaluate the efficacy of primary systemic chemotherapy with docetaxel followed by cyclophosphamide, epirubicin and fluoraouracil (DOC-CEF) in breast cancer. Methods: Since 2003, 80 women histologically proven as the primary breast cancer, measurable lesion >= 2cm or inflammatory breast cancer, age 20–75, PS 0–1 were enrolled. The patients received 4 cycles of DOC (75mg/m2) every 3 weeks followed by CEF (500mg/m2, 75mg/m2, 500mg/m2) every 3 weeks as the primary systemic chemotherapy. After administrations, clinical responses and tumor vascularities were recorded by ultrasonography and pathological responses were examined after surgery for all patients. Results: 57 out of 80 patients (T2: 45, T3 6, T4 6) were analyzed at this time. Clinical response rate recorded by ultrasonography and pathological response rate were 82.4% (47/57) and 91.2% (52/57) respectively. Pathological CR rate was 26.3% (15/57). 8 pCR cases showed ER/PR-negative tumors of which 3 cases showed ER/PR-negative/Her2-negative (triple negative pattern). Breast conservative surgery was underwent in 51 patients (89.5%). Among the response group, the tumor vascularities were almost remarkably decreased in the early phase (mostly until 2–3 cycles) of the chemotherapy. Grade 4 neutropenia was observed in 16% (9/57) and 4% (2/57) had febrile neutropenia. Conclusion: This regimen is well tolerated and has good feasibility because most patients have experienced the early reduction of tumor by high response rate of docetaxel. No significant financial relationships to disclose.

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