scholarly journals A CASE OF GIANT RECTAL GIST SUCCESSFULLY RESECTED AFTER NEOADJUVANT THERAPY WITH IMATINIB MESYLATE

2010 ◽  
Vol 71 (7) ◽  
pp. 1806-1811
Author(s):  
Koushi OH ◽  
Norihiro NAKAI ◽  
Toshihiro OKADA ◽  
Yuji IIMURO ◽  
Seiichi HIROTA ◽  
...  
Keyword(s):  
Neoadjuvant Therapy ◽  
Imatinib Mesylate ◽  
Rectal Gist

scholarly journals A Case of Rectal GIST Treated with Imatinib Mesylate Neoadjuvant Therapy to Preserve the Anus and Curative Resection

2012 ◽  
Vol 65 (4) ◽  
pp. 239-244 ◽  
Author(s):  
Kuniyuki Kato ◽  
Koki Otsuka ◽  
Tetsuya Itabashi ◽  
Yuji Akiyama ◽  
Masakazu Yoshida ◽  
...  
Keyword(s):  
Neoadjuvant Therapy ◽  
Imatinib Mesylate ◽  
Curative Resection ◽  
Rectal Gist

Recurrent rectal GIST resected successfully after preoperative chemotherapy with imatinib mesylate

2008 ◽  
Vol 13 (4) ◽  
pp. 355-360 ◽  
Author(s):  
Madoka Hamada ◽  
Kazuhide Ozaki ◽  
Tadashi Horimi ◽  
Akihito Tsuji ◽  
Yoshitsugu Nasu ◽  
...  
Keyword(s):  
Imatinib Mesylate ◽  
Preoperative Chemotherapy ◽  
Rectal Gist

scholarly journals A CASE OF SURGICAL RESECTION OF RECTAL GASTROINTESTINAL STROMAL TUMOR AFTER NEOADJUVANT THERAPY WITH IMATINIB MESYLATE

2011 ◽  
Vol 72 (11) ◽  
pp. 2877-2881 ◽  
Author(s):  
Naoki MASHITA ◽  
Hiroyuki YOKOYAMA ◽  
Kenji TANIGUCHI ◽  
Katsumi KOSHIKAWA ◽  
Yoshinari MOCHIZUKI ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Neoadjuvant Therapy ◽  
Imatinib Mesylate ◽  
Surgical Resection ◽  
Stromal Tumor

Dermatofibrosarcoma protuberans: Neoadjuvant therapy with imatinib mesylate and use of plasma PDGF-B levels to monitor clinical response

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 9049-9049 ◽  
Author(s):  
M. Macapinlac ◽  
T. Elrafei ◽  
I. Cunningham ◽  
M. Horowitz ◽  
P. Fauzia ◽  
...  
Keyword(s):  
Clinical Response ◽  
Neoadjuvant Therapy ◽  
Imatinib Mesylate ◽  
Dermatofibrosarcoma Protuberans

scholarly journals Imatinib mesylate-induced kidney injury in the treatment of a gastrointestinal stromal tumor

2016 ◽  
Vol 4 (1) ◽  
pp. 30
Author(s):  
Kevin Zarrabi ◽  
Keith Sweeny ◽  
Roger Keresztes
Keyword(s):  
Serum Creatinine ◽  
Imatinib Mesylate ◽  
Renal Injury ◽  
Treatment Guidelines ◽  
Kidney Injury ◽  
Current Treatment ◽  
Treatment Modalities ◽  
Drug Discontinuation ◽  
Rare Type ◽  
Rectal Gist

Gastrointestinal stromal tumors (GISTs) are a rare type of neoplasm arising within the gastrointestinal tract. Current treatment guidelines employ target-based therapy and adjuvant treatment with imatinib mesylate. We report a case of imatinib-induced renal injury in a 48-year-old male undergoing adjuvant chemotherapy after surgical resection of a rectal GIST. Upon initiation of imatinib therapy, the patient’s serum creatinine steadily rose and met criteria for kidney injury after twenty months of therapy. Drug discontinuation led to a normalization of renal function, but upon reinitiating therapy the serum creatinine sharply increased again. The patient’s recurrent acute renal injury led to indefinite drug discontinuation. Imatinib toxicities have been well studied; however, there are no reports to date noting its renal effects in the GIST patient population. This case report highlights imatinib as therapy for GISTs, describes an event of imatinib-induced renal injury, and reviews current treatment modalities.

Neoadjuvant therapy with imatinib mesylate for locally advanced GI stromal tumor

2005 ◽  
Vol 61 (4) ◽  
pp. 625-627 ◽  
Author(s):  
Janak N. Shah ◽  
Weijing Sun ◽  
Raja R. Seethala ◽  
Virginia A. LiVolsi ◽  
Robert D. Fry ◽  
...  
Keyword(s):  
Neoadjuvant Therapy ◽  
Imatinib Mesylate ◽  
Locally Advanced ◽  
Stromal Tumor ◽  
Gi Stromal Tumor

Dermatofibrosarcoma protuberans: Neoadjuvant therapy with imatinib mesylate and use of plasma PDGF-B levels to monitor clinical response

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 9049-9049
Author(s):  
M. Macapinlac ◽  
T. Elrafei ◽  
I. Cunningham ◽  
M. Horowitz ◽  
P. Fauzia ◽  
...  
Keyword(s):  
Clinical Response ◽  
Neoadjuvant Therapy ◽  
Imatinib Mesylate ◽  
Dermatofibrosarcoma Protuberans
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