scholarly journals A CASE REPORT OF THYROID AND LUNG METASTASES WITH INTRA-TRACHEAL INVASION OF RENAL CELL CARCINOMA DEVELOPED 9 YEARS AFTER RIGHT NEPHRECTOMY FOR RENAL CELL CARCINOMA

2009 ◽  
Vol 70 (6) ◽  
pp. 1848-1854 ◽  
Author(s):  
Hidefumi KUBO ◽  
Masahiro KITAHARA ◽  
Kousuke TADA ◽  
Makoto MIYAHARA ◽  
Hiroyasu HASEGAWA
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Lung Metastases ◽  
Tracheal Invasion

Multiple Skeletal Muscle Metastases of Renal Cell Carcinoma after Nephrectomy: Case Report

2004 ◽  
Vol 51 (3) ◽  
pp. 337
Author(s):  
Seung Hyun Cho ◽  
Young Hwan Lee ◽  
Kyung Jae Jung ◽  
Young Chan Park ◽  
Ho Kyun Kim ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Renal Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Skeletal Muscle Metastases

Renal cell carcinoma metastasis to thyroid tumor: a case report

2017 ◽  
Author(s):  
Carolina Faria ◽  
David Barbosa ◽  
Ana Sofia Osorio ◽  
Ema Nobre ◽  
Maria Joao Bugalho
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Thyroid Tumor ◽  
Renal Cell Carcinoma Metastasis ◽  
Carcinoma Metastasis

Pazopanib in Renal Cell Carcinoma Dialysis Patients: A Mini-Review and a Case Report

2016 ◽  
Vol 17 (15) ◽  
pp. 1755-1760 ◽  
Author(s):  
Melissa Bersanelli ◽  
Francesco Facchinetti ◽  
Marcello Tiseo ◽  
Mariarosa Maiorana ◽  
Sebastiano Buti
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Dialysis Patients

scholarly journals Hyperprogressive disease after radiotherapy combined with anti-PD-1 therapy in renal cell carcinoma: a case report and review of the literature

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chao Liu ◽  
Jingjing Piao ◽  
Zhiyang Shang
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
General Condition ◽  
Renal Cell ◽  
Checkpoint Inhibitors ◽  
Lung Metastases ◽  
Left Lung ◽  
The Third ◽  
Bidirectional Regulation ◽  
Hyperprogressive Disease

Abstract Background Studies have shown that immune checkpoint inhibitors (ICIs) have limited efficacy and can even increase tumour burden in short time periods. This is usually called hyperprogressive disease (HPD). To date, there are few reports regarding HPD; fewer have analysed the relationship between HPD and radiotherapy combined with ICIs, and their conclusions are controversial. Case presentation A 42-year-old woman was diagnosed with stage IV renal clear cell carcinoma. The patient had previously received sorafenib and pazopanib as first- and second-line therapies, respectively. She received radiotherapy combined with nivolumab. Eighteen days after administration of the third dose of nivolumab, the patient’s general condition deteriorated; this was associated with immune-related adverse events. Computed tomography showed that the diameter of left lung metastases had sharply increased. A biopsy of the lung metastasis showed no infiltration of lymphocytes. The patient’s general condition worsened and she died of the disease on the 70th day after administration of the third dose of nivolumab. Conclusions This report describes the development of HPD following the administration of radiotherapy combined with ICIs in a case of advanced renal cell carcinoma. The case indicates that radiotherapy may show bidirectional regulation effects on anti-tumour immune response. If the immunosuppressive function of radiotherapy is dominant, combined with ICIs, it could result in HPD.

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