scholarly journals A CASE OF A LARGE GASTRIC GIST HAVING A CENTRAL NECROTIC LESION PERFORATED TO GASTRIC LUMEN AFTER IMATINIB MESILATE TREATMENT

2009 ◽  
Vol 70 (4) ◽  
pp. 1044-1048 ◽  
Author(s):  
Nobuhiro KURITA ◽  
Mitsuo SHIMADA ◽  
Takashi IWATA ◽  
Masanori NISHIOKA ◽  
Kozo YOSHIKAWA ◽  
...  
Keyword(s):  
Necrotic Lesion ◽  
Gastric Gist ◽  
Gastric Lumen ◽  
Imatinib Mesilate

scholarly journals A CASE OF GASTRIC GIST WITH MULTIPLE LIVER METASTASES THAT FOLLOWED CHARACTERISTIC CHANGES WITH ADMINISTRATION OF IMATINIB MESILATE (STI571)

2005 ◽  
Vol 66 (11) ◽  
pp. 2792-2796 ◽  
Author(s):  
Takashi GOTO ◽  
Shoji TANIGUCHI ◽  
Atsushi YAMAMOTO ◽  
Ken NAKASHIMA ◽  
Kazuhiko IBUSUKI ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Gastric Gist ◽  
Multiple Liver Metastases ◽  
Imatinib Mesilate

scholarly journals 1067 ENDOSCOPIC RESECTION OF A LARGE ULCERATED GASTRIC GIST: MANAGING CHALLENGES ON THE ROAD TO RESECTION

2020 ◽  
Vol 91 (6) ◽  
pp. AB94
Author(s):  
Jorge A. Perales Oliva ◽  
Kavel Visrodia ◽  
Amrita Sethi
Keyword(s):  
Endoscopic Resection ◽  
Gastric Gist ◽  
The Road ◽  
On The Road

scholarly journals STR technique for the detection of contamination by exogenous DNA in paraffin blocks and histological slides

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Denise Barcelos ◽  
Karina Funabashi ◽  
Susana Mazloum ◽  
Mariana Fernandes ◽  
Leonardo Cardili
Keyword(s):  
Target Therapy ◽  
Genetic Material ◽  
Gastric Gist ◽  
Sequence Analyses ◽  
Laboratory Procedure ◽  
Exogenous Dna ◽  
Stromal Tumors ◽  
Specific Target ◽  
Different Types ◽  
Short Tandem

Abstract Gastrointestinal Stromal Tumors (GIST) present different types of mutations that may or may not be sensitive to specific target therapy. The laboratory procedure required to prepare histological sections traditionally demands multiple steps, making the process prone to contamination by exogenous genetic material (DNA). An eventual contamination of the biological sample with exogenous DNA may jeopardize subsequent analysis of mutations. The Short Tandem Repeat (STR) technique is frequently used in forensic science fields and presents a potential application in surgical pathology, especially in situations of suspected sample exchange. In the present study, the objective is to verify the possible contamination by exogenous DNA in gastric GIST samples and to evaluate if the presence of contamination can interfere in the detection of the mutations of interest. We assessed eight gastric GISTs by the Sanger sequencing and STR sequence analyses. Seven samples presented more than one profile, a result interpreted as contamination. Our results indicate that exogenous DNA contamination occurred in most of the samples studied and that this was more frequent in samples obtained from the slides than those obtained from the block. The presence of contamination did not inhibit the detection of the mutations of interest for a specific target therapy. Furthermore, the histologic block revealed to be more advantageously when compared to the slide for molecular pathology diagnosis.

scholarly journals Hair loss in an infant presenting with failure to thrive

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110202
Author(s):  
Baninder Kaur Baidwan ◽  
Cara J Haberman
Keyword(s):  
Hair Loss ◽  
Caloric Intake ◽  
Failure To Thrive ◽  
Filling Defect ◽  
Parental Report ◽  
Hair Pulling ◽  
Food Material ◽  
Gastric Bezoar ◽  
Gastric Lumen ◽  
Upper Gastrointestinal

An 11-month-old male child with a complex past medical history presented for admission due to failure to thrive. He had hair loss throughout his scalp, and his abdomen was distended. There was parental report of hair pulling and hair in his stool. An upper gastrointestinal (GI) radiograph with fluoroscopy was performed and showed a filling defect in the gastric lumen. On endoscopy, he was found to have a gastric bezoar consisting of hair, nail, and food material. The trichobezoar was removed, and he began to tolerate feeds and showed consistent weight gain. There were no recurrence of symptoms 8 months following removal. While inadequate caloric intake is a common reason for failure to thrive, mechanical obstruction from a trichobezoar as a cause is rare and to our knowledge has not been reported in a child this young.

“LAPAROSCOPIC INTRAGASTRIC EXCISION OF POSTERIORLY LOCATED GASTRIC GIST USING CONVENTIONAL LAPAROSCOPIC INSTRUMENTS – A CASE REPORT”

2021 ◽  
pp. 29-31
Author(s):  
Kulwant Singh Bhau ◽  
Iqbal Saleem Mir ◽  
Mufti Mahmood Ahmad
Keyword(s):  
Gastric Wall ◽  
Surgical Excision ◽  
Anterior Wall ◽  
Minimal Invasive ◽  
Point Of View ◽  
Gastric Gist ◽  
Safe Procedure ◽  
Conventional Laparoscopic ◽  
Laparoscopic Instruments ◽  
Anterior Gastric Wall

Background: Gastro-intestinal stromal tumour (GIST) commonly involves stomach. Recently there has been an inclination towards managing these benign but potentially malignant lesions by minimal invasive techniques. Surgical excision of gastric GIST mostly requires anterior wall gastrostomy especially for intraluminal lesions. The size and location of the lesion are critical from technical point of view. Lesions located at gastro-esophageal junction requires larger anterior gastric wall opening to reach the site of tumour for excision. Endoscopic excision for such lesions is not always amenable. We performed excision of a posteriorly locat Methods: ed gastric GIST at GE junction by hitching the anterior gastric wall with the anterior abdominal wall and by directly creating pneumogastrium percutaneously for placing three intra-gastric trocars. Results: Patient was discharged on post-operative day 3 in a satisfactory condition. Histopathology revealed complete resection of GIST lesion with margins free from tumour. Immuno-histochemistry (IHC) conrmed it to be GIST with low malignant potential and patient was advised regular follow up. Laparoscopic intra-gastric excision of a posteriorly located gast Conclusion: ro-oesophageal junction GIST lesion after creating pneumogastrium and using conventional laparoscopic instruments is a safe procedure

Rare necrotic lesion in a pregnant woman

2018 ◽  
Vol 71 (5) ◽  
pp. 472-472 ◽  
Author(s):  
James Wiggins ◽  
Emily Hayes ◽  
Marc Heymann ◽  
Rand Hawari ◽  
Richard A Carr
Keyword(s):  
Pregnant Woman ◽  
Necrotic Lesion

Possible mediation by luminal somatostatin of bombesin-induced satiety in the cat

1992 ◽  
Vol 263 (1) ◽  
pp. R84-R88
Author(s):  
A. Bado ◽  
L. Moizo ◽  
J. P. Laigneau ◽  
M. Gauthier ◽  
M. Dubrasquet ◽  
...  
Keyword(s):  
Food Intake ◽  
Intragastric Administration ◽  
Gastric Fistula ◽  
Daily Food ◽  
Dependent Inhibition ◽  
Gastric Lumen ◽  
Dose Dependent Inhibition ◽  
Bombesin Receptor ◽  
Dose Dependent ◽  
Somatostatin 14

Intravenous bombesin produced a dose-related stimulation of luminal gastric somatostatin output and a concomitant dose-dependent inhibition of food intake in the gastric fistula cat. Maximal food intake inhibition was observed at 1,280 pmol.kg-1.h-1 and corresponded to 65 +/- 7% (P less than 0.01). These effects of bombesin were dose dependently abolished by the specific bombesin-receptor antagonist, [Leu13-psi(CH2NH)-Leu14]bombesin. Furthermore, intragastric administration of somatostatin-14, at doses corresponding to those found in the gastric lumen in response to intravenously administered bombesin, significantly inhibited the first 30 min of food intake. This administration had however no effect on total (daily) food intake. We therefore suggest that luminal gastric somatostatin could at least account for bombesin-induced short-term satiety.

scholarly journals Focus on the totally laparoscopic feeding gastrostomy tube placement operative technique

2021 ◽  
Vol 9 (1) ◽  
pp. 127-133
Author(s):  
Sorin Cimpean ◽  
Alexandre Grapotte ◽  
Nicolas Boyer ◽  
Mathilde Poras ◽  
Dario Raglione ◽  
...  
Keyword(s):  
Length Of Hospital Stay ◽  
Feeding Tube ◽  
Tube Placement ◽  
Laparoscopic Technique ◽  
Complication Rates ◽  
Readmission Rates ◽  
Gastric Lumen ◽  
Gastrostomy Tube Placement ◽  
Totally Laparoscopic ◽  
The Cost

Laparoscopic feeding gastrostomy placement is a surgical operation that allows the feeding of malnourished patients through a tube that is placed in the gastric lumen. The benefits of an improved nutritional status in terms of improving clinical outcomes are well documented in the literature and consist in a reduction of the complication rates of the surgical patients, the length of hospital stay, the readmission rates, and a reduction of the cost of health services by reducing the morbidity or mortality. We present a totally laparoscopic technique of feeding tube placement.

scholarly journals A Case of Liver Metastasis from Gastric GIST Resected after Imatinib Mesylate Therapy

2020 ◽  
Vol 81 (9) ◽  
pp. 1780-1785
Author(s):  
Yosuke MORIMOTO ◽  
Koji FUJITA ◽  
Hiroyuki KIKUNAGA ◽  
Hiroshi MIURA ◽  
Syojiro MORINAGA ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Imatinib Mesylate ◽  
Gastric Gist

scholarly journals Splenosis mimicking gastric obstructive tumor. Diagnostic workup.

2021 ◽  
Author(s):  
Vaia-Aliki Rompou ◽  
Dimitrios Korkolis ◽  
Evelina Skafida ◽  
Dimitrios Tsamis ◽  
Aris Plastiras
Keyword(s):  
Surgical Resection ◽  
Male Patient ◽  
Splenic Rupture ◽  
Diagnostic Workup ◽  
Gastric Gist ◽  
History Of

Splenosis is a condition that occurs after splenic rupture. A 29 year-old male patient with a history of splenectomy, was admitted due to multiple vomiting episodes. The diagnostic workup was unable to differentiate between gastric GIST and splenosis. Laparoscopic surgical resection was performed leading to the diagnosis of splenosis.

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