scholarly journals A CASE OF COLITIS DUE TO CYTOMEGALOVIRUS INFECTION AFTER SIMULTANEOUS PANCREAS-KIDNEY TRANSPLANTATION

2008 ◽  
Vol 69 (3) ◽  
pp. 594-597
Author(s):  
Yuichi FUMIMOTO ◽  
Masahiro TANEMURA ◽  
Hiroshi KOMODA ◽  
Toshirou NISHIDA ◽  
Yoshiki SAWA ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Cytomegalovirus Infection ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Simultaneous Pancreas Kidney Transplantation

scholarly journals A Valine Mismatch at Position 129 of MICA Is an Independent Predictor of Cytomegalovirus Infection and Acute Kidney Rejection in Simultaneous Pancreas–Kidney Transplantation Recipients

2018 ◽  
Vol 19 (9) ◽  
pp. 2618 ◽  
Author(s):  
Rafael Michita ◽  
José Chies ◽  
Sabine Schramm ◽  
Peter Horn ◽  
Falko Heinemann ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Natural Killer ◽  
Cytomegalovirus Infection ◽  
Independent Predictor ◽  
Soluble Form ◽  
First Year ◽  
Post Transplantation ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Simultaneous Pancreas Kidney Transplantation

The polymorphic major histocompatibility complex class I chain-related molecule A (MICA) and its soluble form (sMICA) interact with activating receptor natural-killer group 2 member D (NKG2D) on natural-killer (NK) and T cells, thereby modifying immune responses to transplantation and infectious agents (e.g., cytomegalovirus). Two single-nucleotide polymorphisms (SNPs), rs2596538GA in the MICA promoter and rs1051792AG in the coding region (MICA-129Val/Met), influence MICA expression or binding to NKG2D, with MICA-129Met molecules showing higher receptor affinity. To investigate the impact of these SNPs on the occurrence of cytomegalovirus infection or acute rejection (AR) in individuals who underwent simultaneous pancreas–kidney transplantation (SPKT), 50 recipient-donor pairs were genotyped, and sMICA levels were measured during the first year post-transplantation. Recipients with a Val-mismatch (recipient Met/Met and donor Val/Met or Val/Val) showed shorter cytomegalovirus infection-free and shorter kidney AR-free survival. Additionally, Val mismatch was an independent predictor of cytomegalovirus infection and kidney AR in the first year post-transplantation. Interestingly, sMICA levels were lower in rs2596538AA and MICA129Met/Met-homozygous recipients. These results provide further evidence that genetic variants of MICA influence sMICA levels, and that Val mismatch at position 129 increases cytomegalovirus infection and kidney AR risk during the first year post-SPKT.

Cytomegalovirus Infection in Simultaneous Pancreas-Kidney Transplantation

2005 ◽  
Vol 37 (6) ◽  
pp. 2848-2850 ◽  
Author(s):  
J. Malaise ◽  
M.J. Ricart ◽  
A. Moreno ◽  
M. Crespo ◽  
L. Fernández-Cruz ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Cytomegalovirus Infection ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Simultaneous Pancreas Kidney Transplantation

scholarly journals Impact of Early Pancreatic Graft Loss on Outcome after Simultaneous Pancreas–Kidney Transplantation (SPKT)—A Landmark Analysis

2021 ◽  
Vol 10 (15) ◽  
pp. 3237
Author(s):  
Lukas Johannes Lehner ◽  
Robert Öllinger ◽  
Brigitta Globke ◽  
Marcel G. Naik ◽  
Klemens Budde ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Graft Survival ◽  
Graft Loss ◽  
Type I ◽  
Kidney Graft ◽  
Landmark Analysis ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Simultaneous Pancreas Kidney Transplantation ◽  
Pancreas Graft

(1) Background: Simultaneous pancreas–kidney transplantation (SPKT) is a standard therapeutic option for patients with diabetes mellitus type I and kidney failure. Early pancreas allograft failure is a complication potentially associated with worse outcomes. (2) Methods: We performed a landmark analysis to assess the impact of early pancreas graft loss within 3 months on mortality and kidney graft survival over 10 years. This retrospective single-center study included 114 adult patients who underwent an SPKT between 2005 and 2018. (3) Results: Pancreas graft survival rate was 85.1% at 3 months. The main causes of early pancreas graft loss were thrombosis (6.1%), necrosis (2.6%), and pancreatitis (2.6%). Early pancreas graft loss was not associated with reduced patient survival (p = 0.168) or major adverse cerebral or cardiovascular events over 10 years (p = 0.741) compared to patients with functioning pancreas, after 3 months. Moreover, kidney graft function (p = 0.494) and survival (p = 0.461) were not significantly influenced by early pancreas graft loss. (4) Conclusion: In this study, using the landmark analysis technique, early pancreas graft loss within 3 months did not significantly impact patient or kidney graft survival over 10 years.

scholarly journals Impact ofde novodonor-specific anti-HLA antibodies on grafts outcomes in simultaneous pancreas-kidney transplantation

2015 ◽  
Vol 29 (2) ◽  
pp. 173-183 ◽  
Author(s):  
Jorge Malheiro ◽  
La Salete Martins ◽  
Sandra Tafulo ◽  
Leonídio Dias ◽  
Isabel Fonseca ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Hla Antibodies ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Simultaneous Pancreas Kidney Transplantation

scholarly journals Experience with Simultaneous Pancreas-kidney Transplantation

1988 ◽  
Vol 208 (4) ◽  
pp. 475-483 ◽  
Author(s):  
HANS W. SOLLINGER ◽  
ROBERT J. STRATTA ◽  
ANTHONY M. DʼALESSANDRO ◽  
MUNCI KALAYOGLU ◽  
JOHN D. PIRSCH ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Simultaneous Pancreas Kidney Transplantation
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