scholarly journals A CASE OF DIAPHRAGM DISEASE OF THE SMALL INTESTINE ASSOCIATED WITH LONG ADMINISTRATION OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS

2008 ◽  
Vol 69 (10) ◽  
pp. 2552-2556
Author(s):  
Shuichi KUSANO ◽  
Norihisa HANADA ◽  
Kazuki HORI ◽  
Yasuyuki TSURUMOTO ◽  
Naomi SAKASHITA ◽  
...  
Keyword(s):  
Small Intestine ◽  
Diaphragm Disease ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals A CASE OF DIAPHRAGM DISEASE OF THE SMALL INTESTINE CAUSED BY NONSTEROIDAL ANTI-INFLAMMATORY DRUGS

2009 ◽  
Vol 70 (5) ◽  
pp. 1402-1405 ◽  
Author(s):  
Hiroshi ASANO ◽  
Kazuto KOZIMA ◽  
Masaharu WADA ◽  
Hidekazu KAYANO ◽  
Nobuji OGAWA ◽  
...  
Keyword(s):  
Small Intestine ◽  
Diaphragm Disease ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Diaphragm disease in emergency surgery

2020 ◽  
Vol 81 (3) ◽  
pp. 1-6
Author(s):  
Diwakar R Sarma ◽  
Pratik Bhattacharya
Keyword(s):  
Risk Factors ◽  
Small Intestine ◽  
Small Bowel ◽  
Small Bowel Obstruction ◽  
Bowel Obstruction ◽  
Emergency Laparotomy ◽  
Diaphragm Disease ◽  
Inflammatory Drugs ◽  
Acute Small Bowel Obstruction ◽  
Anti Inflammatory

Background/Aims Diaphragm disease of the small bowel has been described in the literature over the last three decades. The pathognomonic characteristic of multiple circumferential stenosis is noted on gross examination of the bowel. It is a severe form of non-steroidal anti-inflammatory drug-induced enteropathy, often presenting as acute small bowel obstruction. A systematic review was performed to identify risk factors and patient outcomes in histologically-proven diaphragm disease of the small intestine in patients undergoing emergency operation for small bowel obstruction. Methods A comprehensive search was performed between January 1975 and March 2019 using relevant MeSH terms. Studies were chosen based on predefined inclusion criteria. Diaphragm disease of the small intestine was defined as macroscopically detected thin diaphragm-like mucosal folding inside the lumen of the bowel. The parameters assessed included patient characteristics, duration of use of non-steroidal anti-inflammatory drugs, type of emergency surgery performed, complications, recurrence, presentation and diagnosis of diaphragm disease. Results A total of 21 studies were analysed which included 17 case reports, one case series, and three retrospective comparative studies. Overall 29 patients with diaphragm disease of the small bowel were reported following emergency laparotomy for small bowel obstruction. Use of non-steroidal anti-inflammatory drugs was noted in all cases with an average duration of 3–5 years. All patients presented acutely with features of small bowel obstruction and had emergency laparotomy, except one who underwent laparoscopic resection. In the comparative studies patients were more likely to be female and to have been taking non-steroidal anti-inflammatory drugs for more than 7 years. Conclusions This is a rare disease, difficult to diagnose and often confirmed by the intra-operative macroscopic appearance of circumferential stenosis of the bowel. Risk factors for developing small bowel diaphragm disease include long-term use of non-steroidal anti-inflammatory drugs, and female gender. Patients with this disease are at increased risk of developing acute small bowel obstruction, so early identification is important.

scholarly journals Diaphragm disease: pathology of disease of the small intestine induced by non-steroidal anti-inflammatory drugs.

1988 ◽  
Vol 41 (5) ◽  
pp. 516-526 ◽  
Author(s):  
J Lang ◽  
A B Price ◽  
A J Levi ◽  
M Burke ◽  
J M Gumpel ◽  
...  
Keyword(s):  
Small Intestine ◽  
Diaphragm Disease ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Effect of non-steroidal anti-inflammatory drugs and prostaglandins on the permeability of the human small intestine.

Gut ◽  
1986 ◽  
Vol 27 (11) ◽  
pp. 1292-1297 ◽  
Author(s):  
I Bjarnason ◽  
P Williams ◽  
P Smethurst ◽  
T J Peters ◽  
A J Levi
Keyword(s):  
Small Intestine ◽  
Human Small Intestine ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Effect of Non-Steroidal Anti-Inflammatory Drugs on the Human Small Intestine

Drugs ◽  
1986 ◽  
Vol 32 (Supplement 1) ◽  
pp. 35-41 ◽  
Author(s):  
I. Bjarnason ◽  
G. Zanelli ◽  
P. Prouse ◽  
P. Williams ◽  
M. J. Gumpel ◽  
...  
Keyword(s):  
Small Intestine ◽  
Human Small Intestine ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Diaphragm disease and small bowel enteropathy due to nonsteroidal anti-inflammatory drugs: a surgical perspective

2011 ◽  
Vol 13 (4) ◽  
pp. 463-466 ◽  
Author(s):  
S. Pilgrim ◽  
V. Velchuru ◽  
G. Waters ◽  
A. Tsiamis ◽  
R. Lal
Keyword(s):  
Small Bowel ◽  
Diaphragm Disease ◽  
Inflammatory Drugs ◽  
Anti Inflammatory
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