scholarly journals A COMBINED CASE OF NONFUNCTIONING ENDOCRINE TUMOR OF THE PANCREATIC HEAD AND CANCER OF THE PANCREATIC BODY AND TAIL

2004 ◽  
Vol 65 (7) ◽  
pp. 1937-1941
Author(s):  
Toshiharu AOTAKE ◽  
Fumie TANAKA ◽  
Hidenori FUJII ◽  
Yuki HIROSE ◽  
Hiroyuki YAMAMOTO ◽  
...  
Keyword(s):  
Pancreatic Head ◽  
Endocrine Tumor ◽  
Pancreatic Body ◽  
Nonfunctioning Endocrine Tumor

scholarly journals Comparative Bioinformatical Analysis of Pancreatic Head Cancer and Pancreatic Body/Tail Cancer

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S54
Author(s):  
L. Yin ◽  
L. Xiao ◽  
Y. Gao ◽  
G. Wang ◽  
H. Gao ◽  
...  
Keyword(s):  
Pancreatic Head ◽  
Head Cancer ◽  
Pancreatic Head Cancer ◽  
Pancreatic Body ◽  
Bioinformatical Analysis

Nonfunctioning endocrine tumor of the pancreas with extrapancreatic growth and cyst formation: Report of a case

Surgery Today ◽  
2000 ◽  
Vol 30 (7) ◽  
pp. 651-654 ◽  
Author(s):  
Kentaro Kato ◽  
Satoshi Kondo ◽  
Yoshiyasu Ambo ◽  
Makoto Omi ◽  
Satoshi Hirano ◽  
...  
Keyword(s):  
Cyst Formation ◽  
Endocrine Tumor ◽  
Nonfunctioning Endocrine Tumor ◽  
Extrapancreatic Growth

scholarly journals Impact of Neoadjuvant Therapy in Resected Pancreatic Ductal Adenocarcinoma of the Pancreatic Body or Tail on Surgical and Oncological Outcome: A Propensity-Score Matched Multicenter Study

2019 ◽  
Vol 27 (6) ◽  
pp. 1986-1996 ◽  
Author(s):  
Sanne Lof ◽  
◽  
Maarten Korrel ◽  
Jony van Hilst ◽  
Adnan Alseidi ◽  
...  
Keyword(s):  
Overall Survival ◽  
Pancreatic Fistula ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Neoadjuvant Therapy ◽  
Survival Benefit ◽  
Pancreatic Head ◽  
Ductal Adenocarcinoma ◽  
Rank Test ◽  
Pancreatic Body ◽  
International Multicenter

Abstract Background Several studies have suggested a survival benefit of neoadjuvant therapy (NAT) for pancreatic ductal adenocarcinoma (PDAC) in the pancreatic head. Data concerning NAT for PDAC located in pancreatic body or tail are lacking. Methods Post hoc analysis of an international multicenter retrospective cohort of distal pancreatectomy for PDAC in 34 centers from 11 countries (2007–2015). Patients who underwent resection after NAT were matched (1:1 ratio), using propensity scores based on baseline characteristics, to patients who underwent upfront resection. Median overall survival was compared using the stratified log-rank test. Results Among 1236 patients, 136 (11.0%) received NAT, most frequently FOLFIRINOX (25.7%). In total, 94 patients receiving NAT were matched to 94 patients undergoing upfront resection. NAT was associated with less postoperative major morbidity (Clavien–Dindo ≥ 3a, 10.6% vs. 23.4%, P = 0.020) and pancreatic fistula grade B/C (9.6% vs. 21.3%, P = 0.026). NAT did not improve overall survival [27 (95% CI 14–39) versus 31 months (95% CI 19–42), P = 0.277], as compared with upfront resection. In a sensitivity analysis of 251 patients with radiographic tumor involvement of splenic vessels, NAT (n = 37, 14.7%) was associated with prolonged overall survival [36 (95% CI 18–53) versus 20 months (95% CI 15–24), P = 0.049], as compared with upfront resection. Conclusion In this international multicenter cohort study, NAT for resected PDAC in pancreatic body or tail was associated with less morbidity and pancreatic fistula but similar overall survival in comparison with upfront resection. Prospective studies should confirm a survival benefit of NAT in patients with PDAC and splenic vessel involvement.

Comparison of the mutation profile between pancreatic head/neck and body/tail cancers.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15752-e15752 ◽  
Author(s):  
Junliang Lu ◽  
Zhiyong Liang ◽  
Huanwen M. Wu ◽  
Junyi Pang ◽  
Xiaolong Liang ◽  
...  
Keyword(s):  
Protein Tyrosine Kinase ◽  
Pancreatic Head ◽  
Clinicopathological Characteristics ◽  
The Body ◽  
Receptor Protein ◽  
Protein Amino Acid ◽  
Kras Mutations ◽  
Pancreatic Body ◽  
Mutation Profile ◽  
Head Neck

e15752 Background: Carcinomas in the pancreatic head/neck and body/tail represent different clinicopathological characteristics, but little is known about the underlying genetic mechanisms. The present study aims to explore the differences in mutation profile between pancreatic head and body/tail cancers. Methods: Fifty-four patients were retrospectively enrolled in the present study. DNA was purified from qualified formalin-fixed, paraffin-embedded tissue blocks of the tumor and corresponding adjacent normal tissue and subjected to target-capture next generation sequencing (TGS). Somatic mutations were identified, which further underwent gene ontology (GO) and KEGG pathway analysis. Results: The most frequently mutated genes in carcinomas of the pancreatic head were KRAS (61.3%), TP53(38.7%), and CDKN2A (16.1%), while that of the pancreatic body/tail were KRAS (95.7%), TP53(87%), CDKN2A (26.1%), and ARID1A (26.1%). The prevalence of TP53 and KRAS mutations in pancreatic head and body/tail cancers were significantly different from each other (p = 0.0006 and p = 0.0037, respectively). Pancreatic head/neck cancers also preserved a broader KRAS mutation spectrum than their counterparts of the body/tail. Pathway analyses revealed that mutations in cancer of pancreatic head/neck were enriched for genes involved in the protein amino acid phosphorylation, regulation of cell proliferation, transmembrane receptor protein tyrosine kinase signaling pathway, and phosphorylation pathways, while cancers of the pancreatic body/tail were enriched for genes involved in colorectal cancers. Conclusions: Cancer of the pancreatic head/neck and body/tail have distinct mutation profiles.

Intraductal growth of a nonfunctioning endocrine tumor of the pancreas

2004 ◽  
Vol 39 (6) ◽  
pp. 584-588 ◽  
Author(s):  
Tomotaka Akatsu ◽  
Go Wakabayashi ◽  
Koichi Aiura ◽  
Kazuhiro Suganuma ◽  
Yutaka Takigawa ◽  
...  
Keyword(s):  
Endocrine Tumor ◽  
Intraductal Growth ◽  
Nonfunctioning Endocrine Tumor

scholarly journals A case of asymptomatic endocrine tumor of the pancreas associated with deficiency of pancreatic body and tail.

2003 ◽  
Vol 64 (2) ◽  
pp. 444-448
Author(s):  
Hiroshi TADA ◽  
Tsuneo KAIHOU ◽  
Hiroshi SHIBUYA ◽  
Masaji HASHIMOTO ◽  
Yutaka HIRANO ◽  
...  
Keyword(s):  
Endocrine Tumor ◽  
Pancreatic Body

Nonfunctioning endocrine tumor arising from intracranial ectopic pancreas associated with congenital brain malformation

2007 ◽  
Vol 23 (11) ◽  
pp. 1337-1340 ◽  
Author(s):  
Hitoshi Tsugu ◽  
Shinya Oshiro ◽  
Hiroshi Kawaguchi ◽  
Takeo Fukushima ◽  
Kazuki Nabeshima ◽  
...  
Keyword(s):  
Endocrine Tumor ◽  
Ectopic Pancreas ◽  
Brain Malformation ◽  
Congenital Brain Malformation ◽  
Nonfunctioning Endocrine Tumor

Pancreatic head well-differentiated endocrine tumor

2011 ◽  
Vol 201 (3) ◽  
pp. e26-e28 ◽  
Author(s):  
Kuang-Chun Hu ◽  
Wen-Hsiung Chang ◽  
Cheng-Hsin Chu ◽  
Tsang-En Wang ◽  
Tao-Yeuan Wang ◽  
...  
Keyword(s):  
Pancreatic Head ◽  
Endocrine Tumor ◽  
Well Differentiated
Sign in / Sign up

Export Citation Format

Share Document