scholarly journals CROHN'S DISEASE WITH MACROCYTIC ANEMIA DUE TO VITAMIN B12 DEFICIENCY AFTER AN ILEOCECAL RESECTION-A REPORT OF A CASE-

2003 ◽  
Vol 64 (4) ◽  
pp. 932-935
Author(s):  
Atsuko FUKAZAWA ◽  
Toshio NAKAMURA ◽  
Keiji MARUYAMA ◽  
Sigeo MIYAZAKI ◽  
Satoshi NAKAMURA
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin B12 ◽  
Macrocytic Anemia ◽  
Vitamin B12 Deficiency ◽  
Ileocecal Resection ◽  
B12 Deficiency

scholarly journals P148 Screening with holotranscobalamin is superior to serum B12 in identifying vitamin B12 deficiency in patients with Crohn's disease

2013 ◽  
Vol 7 ◽  
pp. S68
Author(s):  
M. Ward ◽  
V. Kariyawasam ◽  
A. Sobczynska-Malefora ◽  
A. Ajaegbu ◽  
J. Sanderson ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency

scholarly journals PWE-093 Screening with Holotranscobalamin is Superior to Serum B12 in Identifying Vitamin B12 Deficiency in Patients with Crohn’S Disease

Gut ◽  
2013 ◽  
Vol 62 (Suppl 1) ◽  
pp. A168.2-A168
Author(s):  
M G Ward ◽  
V C Kariyawasam ◽  
P A Blaker ◽  
K V Patel ◽  
R M Goel ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency

S1050 Vitamin B12 Deficiency in Crohn's Disease: Oral Supplementation Is Effective

2009 ◽  
Vol 136 (5) ◽  
pp. A-177-A-178
Author(s):  
Santiago García López ◽  
Sonia Gallego Montañes ◽  
Fernando Gomollon ◽  
Marta Gracia Ruiz ◽  
Raquel Vicente Lidón
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Oral Supplementation ◽  
B12 Deficiency

scholarly journals Oral Symptoms Related to Vitamin B12 Deficiency in a Patient with Crohn's Disease

2017 ◽  
Vol 42 (1) ◽  
pp. 25-27
Author(s):  
Joo-Hee Lee ◽  
Youn-Jung Park ◽  
Jeong-Seung Kwon ◽  
Young-Gun Kim ◽  
Hyung-Joon Ahn
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency ◽  
Oral Symptoms

An Analysis of Transcobalamin II Gene Polymorphisms and Serum Levels of Homocysteine, Folate and Vitamin B12 in Chinese Patients with Crohn's Disease

2017 ◽  
Vol 35 (5) ◽  
pp. 463-471
Author(s):  
Shuzi Zheng ◽  
Chaoqun Wu ◽  
Wei Yang ◽  
Xuanping Xia ◽  
Xiuqing Lin ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin B12 ◽  
Mutant Allele ◽  
Vitamin B12 Deficiency ◽  
Folate Deficiency ◽  
Serum Homocysteine ◽  
B12 Deficiency ◽  
Folate And Vitamin B12 ◽  
Transcobalamin Ii

Objectives: The study aimed to investigate the association of Crohn's disease (CD) with transcobalamin II (TCN2) polymorphisms and serum homocysteine, folate, and vitamin B12 levels. Methods:TCN2 (rs1801198, rs9606756) were genotyped by iMLDR in 389 CD patients and 746 controls. Furthermore, 102 CD patients and 153 controls were randomly selected for examination of serum homocysteine, folate, and vitamin B12 levels by enzymatic cycling assay and chemiluminescence immunoassay, respectively. Results: Mutant allele (G) and genotype (AG + GG) of (rs9606756) were higher in CD patients than in controls (both p < 0.05). So were they in ileocolonic CD patients and stricturing CD patients compared to controls (all p < 0.05). Mutant allele (G) and genotype (CG + GG) of (rs1801198) were more prevalent in stricturing CD patients than in controls (both p < 0.05). Compared to controls, average homocysteine level was enhanced in CD patients (p = 0.003), whereas average folate and vitamin B12 levels were reduced in CD patients (both p < 0.001). The prevalence of hyperhomocysteinemia, folate deficiency, and vitamin B12 deficiency was higher in CD patients than in controls (all p < 0.01). Both folate deficiency and vitamin B12 deficiency were independently related to risk of CD (both p < 0.01). Conclusion:TCN2 (rs1801198, rs9606756) polymorphisms as well as folate deficiency and vitamin B12 deficiency are correlated with CD.

scholarly journals Oral Cyanocobalamin is Effective in the Treatment of Vitamin B12 Deficiency in Crohn’s Disease

Nutrients ◽  
2017 ◽  
Vol 9 (3) ◽  
pp. 308 ◽  
Author(s):  
Fernando Gomollón ◽  
Carla Gargallo ◽  
Jose Muñoz ◽  
Raquel Vicente ◽  
Alberto Lue ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency

scholarly journals P139 - Vitamin B12 deficiency in Crohn's disease: oral supplementation is effective

2009 ◽  
Vol 3 (1) ◽  
pp. S66
Author(s):  
F. Gomollón ◽  
M. Gracia Ruiz ◽  
R. Vicente Lidón ◽  
S. Gallego Montañes ◽  
B. Sicilia Aladrén ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Oral Supplementation ◽  
B12 Deficiency

scholarly journals Hematologic Manifestations of Vitamin B12 Deficiency in Swine

Blood ◽  
1951 ◽  
Vol 6 (10) ◽  
pp. 867-891 ◽  
Author(s):  
G. E. CARTWRIGHT ◽  
BETTY TATTING ◽  
JEAN ROBINSON ◽  
N. M. FELLOWS ◽  
F. D. GUNN ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Vitamin B12 ◽  
Liver Damage ◽  
Megaloblastic Anemia ◽  
Macrocytic Anemia ◽  
Vitamin B12 Deficiency ◽  
Deficiency Anemia ◽  
Severe Neutropenia ◽  
Pteroylglutamic Acid ◽  
B12 Deficiency

Abstract In an effort to produce a deficiency of vitamin B12 a total of 70 pigs were fed a purified diet containing soybean alpha protein in place of casein. One group of animals was started on the diet at 2 to 7 days of age. A second group began at 21 to 28 days of age. Methionine, iodinate casein, desiccated thyroid and pteroylglutamic acid were added to the diet of certain animals and! omitted from the diet of other pigs. In addition, 9 pigs were gastrectomized. Forty-three of the animals survived for a sufficiently long period of time for adequate evaluation of the results of the experiment. Severe liver damage was observed in 24 of the 25 animals autopsied. The only animal not showing liver damage received vitamin B12 from the beginning of the experiment. Necrosis of the liver cells, fatty infiltration, or both, occurred in the presence of a high fat diet containing apparently adequate amounts of protein, choline, vitamin E and methionine. These pathologic changes were apparently prevented but not reversed by the administration of vitamin B12. Growth of the animals on the above diets without added vitamin B12 was retarded as compared with the growth of animals on the same diet supplemented with this vitamin. The administration of vitamin B12 to the deficient animals resulted in rapid growth. Of the 39 animals not receiving vitamin B12 13 failed to develop anemia, 16 developed a mild anemia and in 10 a moderately severe anemia was present. When present the anemia was normocytic and in 24 pigs was accompanied by a moderately severe neutropenia. Differential cell counts on the sternal marrow were normal except for a slight increase in the proportion of normoblasts. These hematologic alterations were neither consistently or completely corrected by the administration of vitamin B12 in spite of the fact that definite and sometimes marked reticulocyte increases followed. When methionine deficiency was associated with vitamin B12 deficiency, anemia appeared to be more severe. The administration of aureomycin, an "animal protein factor," did not stimulate growth and failed to induce a hemopoietic response. There was no macrocytic anemia, the bone marrow was not megaloblastic, and neurologic disturbances or morphologic alterations in the neutrophils were not observed. These results are in contrast to those obtained in pigs with an experimentally produced deficiency of pteroylglutamic acid. Such animals develop macrocytic anemia, leukopenia and a macronormoblastic type of bone marrow. It is not possible to give with any assurance the reason why megaloblastic anemia was not produced in the "B12-deficient" animals. This may have been due to the fact that (1) the deficiency was not sufficiently severe to result in such a change in the hemopoietic system; or (2) because pteroylglutamic acid prevents the development of megaloblastic anemia even in the absence of vitamin B12.

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