scholarly journals A STUDY OF MMPs, TIMPs EXPRESSION AND PATHOLOGICAL MALIGNANT POTENTIAL IN GASTRIC CANCER DISTINGUISHED BY PRESENCE OF AFP PRODUCTION

2003 ◽  
Vol 64 (6) ◽  
pp. 1298-1304
Author(s):  
Jiro SHIMAZAKI ◽  
Masayuki ITABASHI ◽  
Satoshi INAGAWA ◽  
Masao HORI ◽  
Motonobu KATANO ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Malignant Potential ◽  
Afp Production

scholarly journals Comparison of clinicopathological features and long-term prognosis between mixed predominantly differentiated-type and pure differentiated-type early gastric cancer

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yutaka Okagawa ◽  
Tetsuya Sumiyoshi ◽  
Hitoshi Kondo ◽  
Yusuke Tomita ◽  
Takeshi Uozumi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Vascular Invasion ◽  
Survival Rates ◽  
Malignant Potential ◽  
Clinicopathological Features ◽  
Node Metastasis ◽  
Group 5 ◽  
Long Term Prognosis

Abstract Background Recent studies have shown that mixed predominantly differentiated-type (MD) early gastric cancer (EGC) might have more malignant potential than pure differentiated-type (PD) EGC. However, no study has analyzed all differentiated-type EGC cases treated endoscopically and surgically. This study aimed to compare the differences in clinicopathological features and long-term prognosis between MD- and PD-EGC. Methods We evaluated all patients with differentiated-type EGCs who were treated endoscopically and surgically in our hospital between January 2010 and October 2014. The clinicopathological features and long-term prognosis of MD-EGC were compared with those of PD-EGC. Results A total of 459 patients with 459 lesions were evaluated in this study; of them, 409 (89.1%) and 50 (10.9%) were classified into the PD and MD groups, respectively. Submucosal invasion was found in 96 (23.5%) patients of the PD group and in 33 (66.0%) patients of the MD group (p < 0.01). The rates of positive lymphatic and vascular invasion and ulceration were significantly higher in the MD group than in the PD group (p < 0.01). The proportion of patients with lymph node metastasis was also significantly higher in the MD group than in the PD group (5 (10%) vs 6 (1.5%), p < 0.01). The 5-year overall and EGC-specific survival rates in the PD group were 88.3 and 99.5%, respectively, while they were 94.0 and 98.0% in the MD group, respectively. Conclusions MD-EGC has more malignant potential than PD-EGC. However, the long-term prognosis of MD-EGC is good and is not significantly different from that of PD-EGC when treated appropriately.

scholarly journals Relationship Between HER2 Expression and AFP Production in Gastric Cancer

2013 ◽  
Vol 24 ◽  
pp. ix31 ◽  
Author(s):  
Y. Horita ◽  
F. Arihara ◽  
S. Hirai ◽  
A. Shimatani ◽  
K. Matsuda ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Her2 Expression ◽  
Afp Production

scholarly journals A Clinical Study on the Malignant Potential of the Remnant Gastric Cancer.

1993 ◽  
Vol 26 (9) ◽  
pp. 2280-2286
Author(s):  
Yoshihiro Moriwaki ◽  
Takashi Suda ◽  
Fumihiko Kito ◽  
Toshio Imada ◽  
Kenzo Okada ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Clinical Study ◽  
Malignant Potential ◽  
Remnant Gastric Cancer

scholarly journals Expression of sushi domain containing two reflects the malignant potential of gastric cancer

2018 ◽  
Vol 7 (10) ◽  
pp. 5194-5204 ◽  
Author(s):  
Shinichi Umeda ◽  
Mitsuro Kanda ◽  
Takashi Miwa ◽  
Haruyoshi Tanaka ◽  
Chie Tanaka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Malignant Potential

scholarly journals The differences of c-Met expression between AFP-producing gastric cancer and common gastric cancer

2017 ◽  
Author(s):  
Fen Luo ◽  
Zhongwen Zhou ◽  
Xiang Mao ◽  
Jun Wang ◽  
Zhiming Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Immunohistochemical Analysis ◽  
Distinct Type ◽  
Gastric Cancers ◽  
High Incidence ◽  
Positive Rate ◽  
Gastric Cancer Patients ◽  
Afp Production

Purpose. AFP-producing gastric cancer is a distinct type of gastric cancer and has a high incidence of liver metastasis. c-Met is considered to play an important role in liver metastasis of gastric cancer. The purpose of this study is to compare the expression of c-Met in AFP-producing gastric cancer and gastric cancers not producing AFP. Methods. 23 patients with AFP-producing gastric cancers[AFP(+)] and 18 gastric cancer patients without AFP production[AFP(-)] were evaluated for c-Met expression using immunohistochemical analysis. Results. The frequencies of c-Met expression in two groups are the same (p&gt;0.05), but AFP(+) group has a much higher strong positive rate of c-Met expression than AFP(-) group (p&lt;0.01). Conclusion. The higher expression of c-Met might be the reason for the high incidence of liver metastasis of AFP-producing gastric cancer.

Loss of Sympathetic Nerve Fibers Around Intratumoral Arterioles Reflects Malignant Potential of Gastric Cancer

2011 ◽  
Vol 18 (8) ◽  
pp. 2281-2288 ◽  
Author(s):  
Hideyo Miyato ◽  
Joji Kitayama ◽  
Hironori Ishigami ◽  
Shoichi Kaisaki ◽  
Hirokazu Nagawa
Keyword(s):  
Gastric Cancer ◽  
Sympathetic Nerve ◽  
Nerve Fibers ◽  
Malignant Potential ◽  
Sympathetic Nerve Fibers

scholarly journals Comparison of Clinicopathological Features and Long-Term Prognosis Between Mixed Predominantly Differentiated-Type and Pure Differentiated-Type Early Gastric Cancer

2020 ◽  
Author(s):  
Yutaka Okagawa ◽  
Tetsuya Sumiyoshi ◽  
Hitoshi Kondo ◽  
Yusuke Tomita ◽  
Takeshi Uozumi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Vascular Invasion ◽  
Survival Rates ◽  
Malignant Potential ◽  
Clinicopathological Features ◽  
Node Metastasis ◽  
Group 5 ◽  
Long Term Prognosis

Abstract Background: Recent studies have shown that mixed predominantly differentiated-type (MD) early gastric cancer (EGC) might have more malignant potential than pure differentiated-type (PD) EGC. However, no study has analyzed all differentiated-type EGC cases treated endoscopically and surgically. This study aimed to compare the differences in clinicopathological features and long-term prognosis between MD- and PD-EGC. Methods: We evaluated all patients with differentiated-type EGCs who were treated endoscopically and surgically in our hospital between January 2010 and October 2014. The clinicopathological features and long-term prognosis of MD-EGC were compared with those of PD-EGC.Results: A total of 459 patients with 459 lesions were evaluated in this study; of them, 409 (89.1%) and 50 (10.9%) were classified into the PD and MD group, respectively. Submucosal invasion was found in 96 (23.5%) of the PD group and in 33 (66.0%) of the MD group (p<0.01). The rates of positive lymphatic and vascular invasion and ulceration were significantly higher in the MD group than in the PD group (p<0.01). The proportion of patients with lymph node metastasis was also significantly higher in the MD group than in the PD group (5 (10%) vs 6 (1.5%), p<0.01). The 5-year overall and EGC-specific survival rates in the PD were 88.3% and 99.5%, respectively, while they were 94.0% and 98.0% in the MD group, respectively. Conclusions: MD-EGC has more malignant potential than PD-EGC. However, the long-term prognosis of MD-EGC is good and is not significantly different from that of PD-EGC when treated appropriately.

scholarly journals Clinicopathological characteristics of mucin phenotype and its relation to the malignant potential in early differentiated gastric adenocarcinoma

2021 ◽  
Vol 19 ◽  
pp. 205873922110540
Author(s):  
Takanobu Akaishi ◽  
Tadashi Yoshizawa ◽  
Satoko Morohashi ◽  
Shintaro Goto ◽  
Takahiro Muroya ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Stage ◽  
Treatment Strategies ◽  
Venous Invasion ◽  
Malignant Potential ◽  
Mucin Phenotype ◽  
Intestinal Phenotype ◽  
The Relationship ◽  
Submucosal Lesion ◽  
E Cadherin

Objectives Mucin phenotype is a tool to classify gastric cancer, but the relationship between mucin phenotype and its malignancy is still controversial. This study aimed to clarify the relationship between mucin phenotype and the malignant potential of gastric cancer. Methods A total of 82 cases of early-stage differentiated adenocarcinoma (submucosal invasion cases) obtained from surgeries were studied by immunohistochemistry. Gastric mucin phenotype and E-cadherin expression were analyzed in the mucosal and submucosal layer. E-cadherin expression was analyzed by using imaging software (ImageJ) for objective data analysis. Furthermore, the mucin phenotypic shift was analyzed from mucosa to submucosa. Results We found that: (1) tumors with intestinal mucin phenotype had statistically more venous invasion in the submucosal lesion; (2) tumors with an intestinal phenotype that showed venous invasion in the submucosal lesion had a higher percentage of tumors that showed loss of phenotype; (3) no dominant change in E-cadherin expression was observed from the mucosa to submucosa. Conclusion Tumors with loss of phenotype and submucosal intestinal phenotype showed predominantly more venous invasion, so examining the identification of phenotypes and phenotype shifts can be expected to be a factor that influences treatment strategies after endoscopic treatment or after surgical resection.

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