scholarly journals A CASE OF BILE DUCT CANCER WITH LONG-TERM SURVIVAL AFTER OPERATION IN SPITE OF RESIDUAL CANCER AT THE RESECTED MARGIN

Author(s):  
Shinichirou OHUCHI ◽  
Taiji SETO ◽  
Takao HANAOKA ◽  
Rikkou LEE ◽  
Yuichi TANAKA ◽  
...  
Surgery Today ◽  
2011 ◽  
Vol 41 (10) ◽  
pp. 1432-1435
Author(s):  
Toshiya Ochiai ◽  
Hisashi Ikoma ◽  
Koji Inoue ◽  
Shuhei Komatsu ◽  
Yasutoshi Murayama ◽  
...  

2006 ◽  
Vol 93 (3) ◽  
pp. 199-205 ◽  
Author(s):  
Massimiliano Veroux ◽  
Carmelo Madia ◽  
Pietro Fiamingo ◽  
Pietro Caglià ◽  
Maurizio Valastro ◽  
...  

2008 ◽  
Vol 74 (1) ◽  
pp. 87-90 ◽  
Author(s):  
Niraj J. Gusani ◽  
J. Wallis Marsh ◽  
Michael A. Nalesnik ◽  
Mitchell E. Tublin ◽  
T. Clark Gamblin

Extrahepatic bile duct tumors, 80 per cent of which are adenocarcinomas, are rare neoplasms accounting for less than two per cent of all cancers. Carcinoid tumor of the extrahepatic bile ducts is a reportable lesion, with only approximately 50 cases described in the literature since 1959. We present a case of a primary extrahepatic bile duct carcinoid tumor resected for cure with the longest reported follow-up time (11 years) after surgery. We also summarize the existing literature with regard to this rare tumor. Our case lends strong support to the notion that extrahepatic biliary carcinoids are generally indolent lesions that, if aggressively resected, can result in excellent long-term survival. Complete excision with clear margins seems to provide the best chance of obtaining long-term survival and cure.


2019 ◽  
Vol 27 (2) ◽  
Author(s):  
A. Surinach ◽  
T. Phung ◽  
O. Abdul-Rahim ◽  
M. Khushman

At 9%, and 2% when diagnosed at advanced stage, the 5-year relative survival rate for pancreatic ductal adenocarcinoma (pdac) is the lowest of any cancer. The currently approved treatment options for metastatic pdac in the United States are folfirinox [irinotecan–fluorouracil (5fu)–leucovorin (lv)–oxaliplatin], gemcitabine–nab-paclitaxel, and liposomal irinotecan plus 5fu–lv. Liposomal irinotecan is a novel formulation of irinotecan encapsulated within a lipid bilayer, which favours localmetabolic activation. The napoli-1 trial demonstrated the efficacy of liposomal irinotecan in combination with 5fu and lv for the treatment of advanced pdac after progression on gemcitabine-based chemotherapy. The 1-year survival in those patients was 25%; however, none had had irinotecan-refractory disease before treatment with liposomal irinotecan. Furthermore, the U.S. National Comprehensive Cancer Network guidelines recommend liposomal irinotecan plus 5fu–lv in patients who have received prior fluoropyrimidine-based therapy if no prior irinotecan therapy has been given. Here, we report a male patient with stage iv cancer of pancreas or bile duct (site unconfirmed) who experienced a prolonged (51 weeks) response to liposomal irinotecan plus 5fu–lv despite prior disease progression on irinotecan. Several factors have previously been associated with long-term survival in patients receiving liposomal irinotecan therapy: no prior irinotecan-based chemotherapy, high Karnofsky performance status score, age 65 years or less, serum carbohydrate antigen 19-9 less than 59 U/mL, neutrophil-to-lymphocyte ratio 5 or less, and absence of liver metastasis. The patient in the present report had none of those characteristics indicative of long-term survival, except his age at diagnosis—47 years.


2005 ◽  
Vol 241 (1) ◽  
pp. 77-84 ◽  
Author(s):  
Jin-Young Jang ◽  
Sun-Whe Kim ◽  
Do Joong Park ◽  
Young Joon Ahn ◽  
Yoo-Seok Yoon ◽  
...  

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