scholarly journals REVIEW OF THE EVALUATION OF THE LIVER FUNCTIONAL RESERVE BASED ON THE INDOCYANINE GREEN DYE TEST IN PATIENTS WITH HEPATOCELLULAR CARCINOMA

2000 ◽  
Vol 61 (2) ◽  
pp. 307-312
Author(s):  
Hisao WAKABAYASHI ◽  
Haruhiro YONEMOTO ◽  
Ken ISHIMURA ◽  
Yukihiko KARASAWA ◽  
Seiji MORI ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Indocyanine Green ◽  
Functional Reserve ◽  
Indocyanine Green Dye ◽  
Liver Functional Reserve

Full Laparoscopic Anatomical Segment 8 Resection for Hepatocellular Carcinoma Using the Glissonian Approach with Indocyanine Green Dye Fluorescence

2019 ◽  
Vol 26 (8) ◽  
pp. 2577-2578 ◽  
Author(s):  
Giammauro Berardi ◽  
Go Wakabayashi ◽  
Kazuharu Igarashi ◽  
Takehiro Ozaki ◽  
Naoyuki Toyota ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Indocyanine Green ◽  
Indocyanine Green Dye ◽  
Glissonian Approach ◽  
Segment 8 ◽  
Dye Fluorescence

scholarly journals Design of Liver Functional Reserve Estimation Technique Based on Optical Densitometry

Diagnostics ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 599
Author(s):  
Ekaterina Savchenko ◽  
Ilya Kolokolnikov ◽  
Elena Velichko ◽  
Victor Osovskikh ◽  
Lyubov Kiseleva ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Treatment Algorithm ◽  
Invasive Technique ◽  
Positive Outcomes ◽  
Test Results ◽  
Reserve Estimation ◽  
Functional Reserve ◽  
Scientific Contribution ◽  
Functional Reserves ◽  
Liver Functional Reserve

This work is aimed at creating a modified invasive technique for assessing the liver’s functional reserves. A study of the degree of hepatodepression is carried out by measuring the plasma elimination of indocyanine green using the method of optical densitometry. This paper presents test results for an aqueous solution and an albumin solution, as well as the results of measurements of plasma elimination of indocyanine green for patients with liver disease. Perfecting the proposed method will make an important scientific contribution to modern diagnostic medicine. Diagnosing the stages in the progression of the disease and its developing complications can make it possible to rapidly correct the patient’s treatment algorithm, achieving positive outcomes in medical practice.

scholarly journals Baseline serum angiopoietin-2 and VEGF levels predict the deterioration of the liver functional reserve during lenvatinib treatment for hepatocellular carcinoma

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0247728
Author(s):  
Taku Shigesawa ◽  
Goki Suda ◽  
Megumi Kimura ◽  
Osamu Maehara ◽  
Yoshimasa Tokuchi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Growth Factor ◽  
Clinical Data ◽  
Characteristic Curve ◽  
Laboratory Data ◽  
Complete Response ◽  
Serum Samples ◽  
Functional Reserve ◽  
Baseline Serum ◽  
Liver Functional Reserve

A deteriorated liver functional reserve during systemic therapy for unresectable hepatocellular carcinoma (HCC) causes poor patient outcomes. We aimed to identify predictive factors associated with the deterioration of Child-Pugh score at 8 weeks after lenvatinib initiation. Patients with adequate clinical data and baseline preserved serum samples available were included. Baseline fibroblast growth factor (FGF)19 and 21, angiopoietin (ANG)2, and vascular endothelial growth factor (VEGF) levels were evaluated. Thirty-seven patients were included, and 6, 15, 14, and 2 experienced complete response, partial response, stable disease, and progressive disease, respectively. Twenty-four (65%) and 13 (35%) patients showed a maintained/improved and deteriorated Child-Pugh-score, respectively. While baseline clinical data, treatment response, and laboratory data were similar between these two patient groups, baseline ANG2 and VEGF levels were significantly higher (P = 0.0017) and lower (P = 0.0231), respectively, in patients with deteriorated Child-Pugh score than in those without. Based on receiver operating characteristic curve analysis, cut-off values for ANG2 and VEGF were found to be 3,108 pg/mL and 514.9 pg/mL, respectively. Among patients with low VEGF and high ANG2, 89% (8/9) exhibited a deteriorated Child-Pugh score, whereas none of the patients (0/9) with high VEGF and low ANG2 did. The deterioration of the Child-Pugh score in patients with unresectable HCC who are treated with lenvatinib may be predictable based on combined baseline serum ANG2 and VEGF levels.

Sign in / Sign up

Export Citation Format

Share Document