scholarly journals Acute hepatic failure due to drug-induced hypersensitivity syndrome: a case report

2015 ◽  
Vol 22 (2) ◽  
pp. 127-131
Author(s):  
Hiroshi Yamamoto ◽  
Rie Shimizu ◽  
Mitsuo Iwasaki ◽  
Marie Ninomiya ◽  
Megumi Okawa ◽  
...  
2010 ◽  
Vol 3 (6) ◽  
pp. 327-331 ◽  
Author(s):  
Takayuki Fusasaki ◽  
Ryoichi Narita ◽  
Masaaki Hiura ◽  
Shintaro Abe ◽  
Akinari Tabaru ◽  
...  

2012 ◽  
Vol 27 (2) ◽  
pp. 130 ◽  
Author(s):  
Young Joo Han ◽  
Jae Wook Choi ◽  
Woo Jin Chung ◽  
Dong In Suh ◽  
June Dong Park

2010 ◽  
Vol 7 (6) ◽  
pp. 373-376
Author(s):  
Pradipta Guha ◽  
Shivesh Shanker Sahai ◽  
Sekhar Mukherjee ◽  
Sanjoy Kumar Chatterjee

2020 ◽  
Vol 13 (1) ◽  
pp. 40-43
Author(s):  
Mujtaba Mohamed ◽  
Alsadiq Al-Hillan ◽  
Marcus Flores ◽  
Christian Kaunzinger ◽  
Arman Mushtaq ◽  
...  

Kanzo ◽  
1977 ◽  
Vol 18 (7) ◽  
pp. 474-479
Author(s):  
Kazuaki YAMAUCHI ◽  
Hirohiko ABE ◽  
Toyoaki MAEYAMA ◽  
Ikuzo AMANO ◽  
Kyuichi TANIKAWA

2020 ◽  
Vol 3 (2) ◽  
pp. 36-37
Author(s):  
Lokesh Shekher Jaiswal ◽  
Narendra Pandit ◽  
Jagat Narayan Prasad

Acute hepatic failure due to ischemic hepatitis is associated with high mortality. The safety of cardiopulmonary bypass in this setting is not fully described. Here we report a case of a 21-year-old female who developed an acute fulminant hepatic failure due to ischemic hepatitis following a cardiogenic shock. She underwent subsequent successful mitral valve replacement under cardiopulmonary bypass, thus providing an evidence of its safety in acute fulminant hepatic failure.


2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Yu Ri Kim ◽  
Nam Jin Lee ◽  
Jung Ok Ban ◽  
Hwan Soo Yoo ◽  
Yong Moon Lee ◽  
...  

High doses of acetaminophen (APAP;N-acetyl-p-aminophenol) cause severe hepatotoxicity after metabolic activation by cytochrome P450 2E1. This study was undertaken to examine the preventive effects of thiacremonone, a compound extracted from garlic, on APAP-induced acute hepatic failure in male C57BL/6J. Mice received with 500 mg/kg APAP after a 7-day pretreatment with thiacremonone (10–50 mg/kg). Thiacremonone inhibited the APAP-induced serum ALT and AST levels in a dose-dependent manner, and markedly reduced the restricted area of necrosis and inflammation by administration of APAP. Thiacremonone also inhibited the APAP-induced depletion of intracellular GSH, induction of nitric oxide, and lipid peroxidation as well as expression of P450 2E1. After APAP injection, the numbers of Kupffer cells, natural killer cells, and cytotoxic T cells were elevated, but the elevated cell numbers in the liver were reduced in thiacremonone pretreated mice. The expression levels of I-309, M-CSF, MIG, MIP-1α, MIP-1β, IL-7, and IL-17 were increased by APAP treatment, which were inhibited in thiacremonone pretreated mice. These data indicate that thiacremonone could be a useful agent for the treatment of drug-induced hepatic failure and that the reduction of cytotoxic immune cells as well as proinflammatory cytokine production may be critical for the prevention of APAP-induced acute liver toxicity.


Sign in / Sign up

Export Citation Format

Share Document