Clinical and hemostasis predictors of mammary gland tumors in bitches

2021 ◽  
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Tumors

scholarly journals Systemic Polyomavirus Genome Increase and Dissemination of Capsid-Defective Genomes in Mammary Gland Tumor-Bearing Mice

2000 ◽  
Vol 74 (15) ◽  
pp. 6975-6983 ◽  
Author(s):  
Julie J. Wirth ◽  
Li Chen ◽  
Michele M. Fluck
Keyword(s):  
Mammary Gland ◽  
Viral Genome ◽  
Wild Type Strain ◽  
Neonatal Infection ◽  
Wild Type ◽  
Coding Region ◽  
Live Virus ◽  
Viral Genomes ◽  
Mammary Gland Tumors ◽  
Low Levels

ABSTRACT BALB/c mice that developed tumors 7 to 8 months following neonatal infection by polyomavirus (PYV) wild-type strain A2 were characterized with respect to the abundance and integrity of the viral genome in the tumors and in 12 nontumorous organs. These patterns were compared to those found in tumor-free mice infected in parallel. Six mice were analyzed in detail including four sibling females with mammary gland tumors. In four of five mammary gland tumors, the viral genome had undergone a unique deletion and/or rearrangement. Three tumor-resident genomes with an apparently intact large T coding region were present in abundant levels in an unintegrated state. Two of these had undergone deletions and rearrangements involving the capsid genes and therefore lacked the capacity to produce live virus. In the comparative organ survey, the tumors harboring replication-competent genomes contained by far the highest levels of genomes of any tissue. However, the levels of PYV genomes in other organs were elevated by up to 1 to 2 orders of magnitude compared to those detected in the same organs of tumor-free mice. The genomes found in the nontumorous organs had the same rearrangements as the genomes residing in the tumors. The original wild-type genome was detected at low levels in a few organs, particularly in the kidneys. The data indicate that a systemic increase in the level of viral genomes occurred in conjunction with the induction of tumors by PYV. The results suggest two novel hypotheses: (i) that genomes may spread from the tumors to the usual PYV target tissues and (ii) that this dissemination may take place in the absence of capsids, providing an important path for a virus to escape from the immune response. This situation may offer a useful model for the spread of HPV accompanying HPV-induced oncogenesis.

scholarly journals Potential role of SC1, a cell adhesion molecule, in mammary gland tumors

2008 ◽  
Author(s):  
Kenji Hagimori ◽  
Hidenori Kato ◽  
Keiko Fukuda ◽  
Masaharu Kikuta ◽  
Yasuhiro Tsukamoto ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Mammary Gland ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Potential Role ◽  
Mammary Gland Tumors ◽  
A Cell

scholarly journals Expression and significance of CHIP in canine mammary gland tumors

2015 ◽  
Vol 77 (11) ◽  
pp. 1465-1471
Author(s):  
Huanan WANG ◽  
Xu YANG ◽  
Yipeng JIN ◽  
Shimin PEI ◽  
Di ZHANG ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Tumors ◽  
Canine Mammary Gland

scholarly journals Reproductive Disturbances, Pituitary Lactotrope Adenomas, and Mammary Gland Tumors in Transgenic Female Mice Producing High Levels of Human Chorionic Gonadotropin

Endocrinology ◽  
2002 ◽  
Vol 143 (10) ◽  
pp. 4084-4095 ◽  
Author(s):  
Susana B. Rulli ◽  
Aino Kuorelahti ◽  
Öznur Karaer ◽  
Lauri J. Pelliniemi ◽  
Matti Poutanen ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Female Mice ◽  
Mammary Gland Tumors

scholarly journals Breast cancer at minors: methodology and clinical

2021 ◽  
Vol 70 (2) ◽  
Author(s):  
Ion Mereuta ◽  
◽  
Veronica Shvet ◽  
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Pediatric Oncology ◽  
Mammary Gland Tumors ◽  
The University ◽  
Methodological Aspects

This article highlights the importance of clinical and methodological aspects of the mammary gland tumors of the girls, and it is based on the study conducted between 2013-2020 in the University Clinic and Pediatric Oncology Department of the INSP IO. The stake of this study was to argue the frequency of the fibroadenomas and phylloid tumors.

scholarly journals Influence of Host Factors on Survival in Dogs with Malignant Mammary Gland Tumors

2003 ◽  
Vol 17 (1) ◽  
pp. 102-106 ◽  
Author(s):  
Jeffrey C. Philibert ◽  
Paul W. Snyder ◽  
Nita Glickman ◽  
Larry T. Glickman ◽  
Deborah W. Knapp ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Host Factors ◽  
Mammary Gland Tumors
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