scholarly journals The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress and advanced glycation end products in experimental nonalcoholic- and alcoholic- fatty liver disease

2021 ◽  
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Liver Damage ◽  
Fatty Liver Disease ◽  
Advanced Glycation ◽  
Dihydroxyvitamin D3 ◽  
Alcoholic Fatty Liver ◽  
Glycation End Products ◽  
End Products ◽  
Alcoholic Fatty Liver Disease

scholarly journals Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease

2016 ◽  
Vol 22 (35) ◽  
pp. 8026 ◽  
Author(s):  
Christopher Leung ◽  
Chandana B Herath ◽  
Zhiyuan Jia ◽  
Sof Andrikopoulos ◽  
Bronwyn E Brown ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Advanced Glycation End Products ◽  
Fatty Liver Disease ◽  
Advanced Glycation ◽  
Alcoholic Fatty Liver ◽  
Glycation End Products ◽  
End Products ◽  
Alcoholic Fatty Liver Disease

scholarly journals Hepatic microvascular dysfunction and increased advanced glycation end products are components of non-alcoholic fatty liver disease

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0179654 ◽  
Author(s):  
Evelyn Nunes Goulart da Silva Pereira ◽  
Raquel Rangel Silvares ◽  
Edgar Eduardo Ilaquita Flores ◽  
Karine Lino Rodrigues ◽  
Isalira Peroba Ramos ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Advanced Glycation End Products ◽  
Fatty Liver Disease ◽  
Microvascular Dysfunction ◽  
Advanced Glycation ◽  
Alcoholic Fatty Liver ◽  
Glycation End Products ◽  
End Products ◽  
Alcoholic Fatty Liver Disease

scholarly journals Development and Progression of Non-Alcoholic Fatty Liver Disease: The Role of Advanced Glycation End Products

2019 ◽  
Vol 20 (20) ◽  
pp. 5037 ◽  
Author(s):  
Dinali H. Fernando ◽  
Josephine M. Forbes ◽  
Peter W. Angus ◽  
Chandana B. Herath
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Advanced Glycation ◽  
Alcoholic Fatty Liver ◽  
Second Hit ◽  
Glycation End Products ◽  
End Products ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the adult population and is now a major cause of liver disease-related premature illness and deaths in the world. Treatment is largely based on lifestyle modification, which is difficult to achieve in most patients. Progression of simple fatty liver or steatosis to its severe form non-alcoholic steatohepatitis (NASH) and liver fibrosis has been explained by a ‘two-hit hypothesis’. Whilst simple steatosis is considered the first hit, its transformation to NASH may be driven by a second hit. Of several factors that constitute the second hit, advanced glycation end products (AGEs), which are formed when reducing-sugars react with proteins or lipids, have been implicated as major candidates that drive steatosis to NASH via the receptor for AGEs (RAGE). Both endogenous and processed food-derived (exogenous) AGEs can activate RAGE, mainly present on Kupffer cells and hepatic stellate cells, thus propagating NAFLD progression. This review focuses on the pathophysiology of NAFLD with special emphasis on the role of food-derived AGEs in NAFLD progression to NASH and liver fibrosis. Moreover, the effect of dietary manipulation to reduce AGE content in food or the therapies targeting AGE/RAGE pathway on disease progression is also discussed.

scholarly journals Contribution of Cyclooxygenase End Products and Oxidative Stress to Intrahepatic Endothelial Dysfunction in Early Non-Alcoholic Fatty Liver Disease

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0156650 ◽  
Author(s):  
Francisco Javier Gonzalez-Paredes ◽  
Goretti Hernández Mesa ◽  
Dalia Morales Arraez ◽  
Raquel Marcelino Reyes ◽  
Beatriz Abrante ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Endothelial Dysfunction ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
End Products ◽  
And Oxidative Stress ◽  
Alcoholic Fatty Liver Disease
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