Mesua ferrea L. (Calophyllaceae) exerts therapeutic effects in allergic asthma by modulating cytokines production in asthmatic rats

2021 ◽  
Vol 45 (SI-2) ◽  
pp. 820-832
Author(s):  
Poonam ARORA
Keyword(s):  
Allergic Asthma ◽  
Therapeutic Effects

Therapeutic effects of resveratrol in a mouse model of HDM-induced allergic asthma

2015 ◽  
Vol 25 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Jiaxiang Chen ◽  
Hao Zhou ◽  
Jinlei Wang ◽  
Baoping Zhang ◽  
Fen Liu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Allergic Asthma ◽  
Therapeutic Effects

Supplementation with Tetrahydrocurcumin Enhances the Therapeutic Effects of Dexamethasone in a Murine Model of Allergic Asthma

2020 ◽  
Vol 181 (11) ◽  
pp. 822-830
Author(s):  
Yin Fan Wu ◽  
Yan Qiu Chen ◽  
Qin Li ◽  
Xiao Yan Ye ◽  
Xiao Zuo ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
Control Group ◽  
Therapeutic Effects ◽  
Dietary Factor ◽  
Th2 Response ◽  
Beneficial Effects ◽  
Nasal Symptoms ◽  
Th Cell ◽  
Cytokine Levels ◽  
Airway Symptoms

<b><i>Background:</i></b> Tetrahydrocurcumin (THC) is the major active metabolite of curcumin, which is a dietary factor derived from <i>Curcuma</i> species. Our previous study demonstrated a significant beneficial effect of THC in mice with allergic asthma. Glucocorticosteroids (GCs) are commonly used drugs in asthma. Whether THC supplementation could promote the beneficial effects of GC therapy on asthma has not yet been reported. The current study aimed to investigate the combined efficacy of GC and THC treatment in a mouse model of allergic asthma. <b><i>Methods:</i></b> BALB/c mice were randomly divided into 5 groups: the control group, ovalbumin (OVA)-induced group, and OVA-induced mice treated with dietary THC only, intraperitoneal injection of dexamethasone (DEX) only, or THC combined with DEX. The nasal symptoms, histopathological alterations of lung tissues, lung cytokine production, and Th cell subsets were assessed. <b><i>Results:</i></b> THC or DEX had beneficial effects on nasal symptoms and pathological lung changes, and the therapeutic effects between THC and DEX treatment were comparable. Importantly, compared to the monotherapy groups (THC or DEX only), the combination of THC and DEX showed a significantly reduced nasal rubbing frequency, lower mucus hyperproduction, lower Th2 and Th17 cell numbers as well as lower related cytokine levels (IL-4, IL-5, and IL-17A). <b><i>Conclusions:</i></b> Supplementation with THC can enhance the therapeutic effects of DEX to alleviate airway symptoms, lung inflammation, and the Th2 response. Our findings suggest that dietary administration of THC could act as an add-on therapy for asthma treated with GCs.

scholarly journals Therapeutic Effects of an Anti-sialyl Lewis X Antibody in a Murine Model of Allergic Asthma

2021 ◽  
Vol 22 (18) ◽  
pp. 9961
Author(s):  
Wei Xiong ◽  
Wenxin Liu ◽  
Shogo Nishida ◽  
Daichi Komiyama ◽  
Wei Liu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Allergic Asthma ◽  
Murine Model ◽  
Ex Vivo ◽  
Lavage Fluid ◽  
Carbohydrate Antigen ◽  
Sialyl Lewis X ◽  
Therapeutic Effects ◽  
Lewis X ◽  
Sialyl Lewis

Asthma is an allergic disease that causes severe infiltration of leukocytes into the lungs. Leukocyte infiltration is mediated by the binding of sialyl Lewis X (sLex) glycans present on the leukocytes to E-and P-selectins present on the endothelial cells at the sites of inflammation. Here, we found that mouse eosinophils express sLex glycans, and their infiltration into the lungs and proliferation in the bone marrow were significantly suppressed by an anti-sLex monoclonal antibody (mAb) F2 in a murine model of ovalbumin-induced asthma. The percentage of eosinophils in the bronchoalveolar lavage fluid and bone marrow and serum IgE levels decreased significantly in the F2-administered mice. Levels of T helper type 2 (Th2) cytokines and chemokines, involved in IgE class switching and eosinophil proliferation and recruitment, were also decreased in the F2-administered mice. An ex vivo cell rolling assay revealed that sLex glycans mediate the rolling of mouse eosinophils on P-selectin-expressing cells. These results indicate that the mAb F2 exerts therapeutic effects in a murine model of allergen-induced asthma, suggesting that sLex carbohydrate antigen could serve as a novel therapeutic target for allergic asthma.

scholarly journals Alanylglutamine Relieved Asthma Symptoms by Regulating Gut Microbiota and the Derived Metabolites in Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-18
Author(s):  
Shao-Kun Liu ◽  
Li-Bing Ma ◽  
Yu Yuan ◽  
Xiao-Ying Ji ◽  
Wen-Jin Sun ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Protein Expression ◽  
Signaling Pathways ◽  
Allergic Asthma ◽  
Butyric Acid ◽  
Short Chain Fatty Acids ◽  
Chronic Inflammatory Disease ◽  
Therapeutic Effects ◽  
Inflammatory Infiltration ◽  
Rdna Sequencing

Objective. Allergic asthma is a chronic inflammatory disease, which seriously affects the life quality of patients, especially children. Alanylglutamine is a nutritional supplement with potential protective and anti-inflammatory effects, but its function in allergic asthma remains elusive. In this study, we focused on the investigations of the roles and functional mechanism of Alanylglutamine in asthma. Methods. Ovalbumin (OVA) induction was utilized to establish a mouse asthma model. 16S rDNA sequencing was performed to compare the diversity of intestinal microorganisms under different treatments. Gas chromatography was utilized to screen the intestinal microbe-short-chain fatty acids in the stool. The lung tissue was extracted to determine signaling pathways, including AMPK, NF-κB, mTOR, STAT3, IKKβ, TGF-β, and IL-1β through Western blot or RT-qPCR. Results. It was observed that Alanylglutamine reduced the cytokine in OVA-induced allergic asthma mice. H&E staining showed obvious pneumonia symptoms in the asthma group, while Alanylglutamine alleviated the inflammatory infiltration. Alanylglutamine reversed gut microbiota compositions in OVA-induced allergic asthma mice and enhanced the butyric acid level. The protective role of Alanylglutamine may be associated with the gut microbiota-butyric acid-GPR43 pathway in asthma mice. In contrast to the OVA group, Alanylglutamine activated the protein expression of P-AMPK/AMPK and inhibited the protein expression of P-mTOR/mTOR, P-P65/P65, P-STAT3/STAT3, P-IKKβ/IKKβ, TGF-β, and IL-1β, with similar effects from butyric acid. Conclusion. The results indicated that Alanylglutamine might be beneficial for asthma, and its effect was achieved through the regulation on microbiota and the derived metabolites. The therapeutic effects might be associated with AMPK, NF-κB, mTOR, and STAT3 signaling pathways. These findings will help identify effective therapeutic direction to alleviate allergic inflammation of the lungs and airways.

scholarly journals Banhahubak-Tang Tablet, a Standardized Medicine Attenuates Allergic Asthma via Inhibition of Janus Kinase 1 (JAK1)/ Signal Transducer and Activator of Transcription 6 (STAT6) Signal Pathway

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2206 ◽  
Author(s):  
Yeon Kyung Nam ◽  
Seong Chul Jin ◽  
Mi Hye Kim ◽  
La Yoon Choi ◽  
Yong-Bok Lee ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Allergic Asthma ◽  
Inflammatory Cytokines ◽  
Inflammatory Cells ◽  
Janus Kinase ◽  
Total Serum ◽  
Therapeutic Effects ◽  
Signal Transducer ◽  
Janus Kinase 1 ◽  
Pro Inflammatory Cytokines

Exposure to particulate matter (PM) has been known to be one of the risk factors to cause allergic asthma, leading to development of respiratory disease. Banhahubak-tang tablet (BHT), a standardized Korean Medicine, is prescribed for neurasthenia, laryngopharyngitis and asthma. In this study, we investigated therapeutic effects of BHT on airway inflammation in ovalbumin (OVA) and PM smaller than 10 μm (PM10)-induced allergic asthma mice. To establish allergic asthma with airway hyper-responsiveness by PM10, BALB/c mice were sensitized and challenged with OVA and PM10, and orally administered BHT. Histological staining was performed to assess airway remodeling. Serum and bronchoalveolar lavage fluid (BALF) was collected for measuring immunoglobulin levels and counting inflammatory cells, respectively. Expression levels of Janus kinase 1 (JAK1)/signal transducer and activator of transcription 6 (STAT6), pro-inflammatory cytokines and type 2 T-helper (Th2)-related cytokines were analyzed in vivo and in vitro models. Histopathological analysis demonstrated that BHT suppressed inflammatory cell infiltration, mucus hypersecretion and collagen deposition in the airway. BHT administration effectively decreased number of inflammatory cells in BALF. BHT reduced total serum Immunoglobulin E (IgE) and Immunoglobulin G (IgG) levels. In addition, BHT significantly inhibited the phosphorylation of JAK1 and STAT6 expressions. Release of pro-inflammatory cytokines and Th2-related cytokines were down-regulated by BHT. In conclusion, BHT mitigated airway inflammation by down-regulating pro-inflammatory and Th2-related cytokines via JAK1/STAT6 signaling. BHT might be a promising herbal medicine for preventing airway inflammation. Moreover, an intervention study among humans is needed to further evaluate the possible beneficial effects of BHT in allergic asthma.

scholarly journals Serum from Asthmatic Mice Potentiates the Therapeutic Effects of Mesenchymal Stromal Cells in Experimental Allergic Asthma

2018 ◽  
Vol 8 (3) ◽  
pp. 301-312 ◽  
Author(s):  
Soraia C. Abreu ◽  
Debora G. Xisto ◽  
Tainá B. de Oliveira ◽  
Natalia G. Blanco ◽  
Lígia Lins de Castro ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Therapeutic Effects ◽  
Experimental Allergic Asthma ◽  
Experimental Allergic
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