A Novel Approach for Conceptual Structural Design of Complex Machine Elements

2016 ◽  
Vol 52 (7) ◽  
pp. 152 ◽  
Author(s):  
Delun WANG
Keyword(s):  
Structural Design ◽  
Novel Approach ◽  
Machine Elements

An Optimality Criterion for the Structural Optimization of Machine Elements

2005 ◽  
Vol 127 (3) ◽  
pp. 415-423 ◽  
Author(s):  
C.-P. Teng ◽  
J. Angeles
Keyword(s):  
Structural Optimization ◽  
Optimality Criterion ◽  
Mass Reduction ◽  
Speed Reduction ◽  
Optimum Dimension ◽  
Novel Approach ◽  
Cam Follower ◽  
Machine Elements ◽  
A Current

Methods of structural optimization have been studied and developed over the last three decades. An important aspect of structural optimization pertains to the condition under which the loads are applied. Most machine structures in operation are subject to loads varying as functions of time. In this paper, a novel approach is proposed to cope with loads whose magnitudes vary within given bounds and with variable directions. The underlying ideas are applied to the structural optimization of the roller-carrying disk of a novel class of cam-follower speed reduction devices termed Speed-o-Cam (SoC). Results obtained in this paper are compared with a current prototype and with an intermediate design in which the dimensions of the roller pins are optimized. Combined with the optimum dimension of the roller pins, our structural-optimization results lead to an improvement of almost twice the stiffness with a mass reduction of 40% of the original prototype.

scholarly journals Evaluating Grease Degradation through Contact Angle Approach

Lubricants ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 11
Author(s):  
Michael M. Khonsari ◽  
K. P. Lijesh ◽  
Roger A. Miller ◽  
Raj Shah
Keyword(s):  
Contact Angle ◽  
Yield Stress ◽  
Water Droplet ◽  
Contact Angles ◽  
Operating Conditions ◽  
Premature Failure ◽  
Novel Approach ◽  
Study Results ◽  
Machine Elements ◽  
Grease Degradation

Grease is highly susceptible to degradation due to regular usage and the severity of the operating conditions. Degradation can negatively impact the performance of grease-lubricated machinery, demanding frequent maintenance to avoid premature failure of machine elements. Quantification of grease degradation has proven to be a formidable task, for which no accepted standards are currently available. In this paper, we extend the results of a novel approach developed recently for the evaluation of the water-resistant property in grease to quantify degradation. The methodology is based on measurements of the contact angle of a water droplet on the surface of a sample of grease. We report the results of extensive tests performed on different grades of lithium complex greases to evaluate the variation of contact angle values with the composition of grease. The measurements were compared with penetrometer readings to quantify a relationship between the grease consistency and contact angle. Detailed study results are also presented on three types of greases sheared in a grease worker for a different number of strokes: contact angle and the yield stress values were measured and compared. Finally, the tribological characteristics were determined for two greases that exhibited a low or high change in their contact angles.

scholarly journals Fatigue lifetime calculation of wind turbine blade bearings considering blade-dependent load distribution

2020 ◽  
Author(s):  
Oliver Menck ◽  
Matthias Stammler ◽  
Florian Schleich
Keyword(s):  
Load Distribution ◽  
Computational Effort ◽  
The Other ◽  
Fatigue Lifetime ◽  
Internal Load ◽  
Load Distributions ◽  
Novel Approach ◽  
Machine Elements ◽  
Bearing Loads ◽  
Yaw Bearing

Abstract. Rotating bearings are some of the most commonly employed machine elements. As such, they are well-understood and thoroughly researched pieces of technology. Fatigue lifetime calculation is internationally standardized through ISO 281 which is based on the assumption that loads act on a bearing under constant rotation. Blade bearings of wind turbines do not conform to this assumption, since their movement typically consists of small, repetitive oscillations. Moreover, their load distribution differs considerably over the bearing circumference, a load case for which ISO 281 refers to ISO 16281 and which requires detailed simulations of the bearing to be sufficiently precise. Aside from ISO 16281, the NREL DG03, a guideline for pitch and yaw bearing lifetime, lists two methods for incorporating bearing loads into the fatigue life calculation. This paper compares all three methods. Load distributions in the bearing are simulated and interpolated by means of a novel approach. The method from NREL DG03 which requires the least computational effort is shown to result in a much higher lifetime than the other two, which are based on internal load distributions of the bearing. The two latter methods are shown to produce very similar results. An adjustment is proposed for increasing the accuracy of that lifetime calculation method which requires the least computational effort in order to resemble the other two more closely.

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov
Keyword(s):  
Oxidative Stress ◽  
Head And Neck ◽  
Transcriptional Activation ◽  
Platinum Resistance ◽  
Mrna Levels ◽  
Strong Positive Correlation ◽  
Platinum Compounds ◽  
Copper Chelation ◽  
Novel Approach ◽  
Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

Collecting Words: A Clinical Example of a Morphology-Focused Orthographic Intervention

2020 ◽  
Vol 51 (3) ◽  
pp. 544-560 ◽  
Author(s):  
Kimberly A. Murphy ◽  
Emily A. Diehm
Keyword(s):  
Written Language ◽  
Morphological Knowledge ◽  
English Orthography ◽  
Word Level ◽  
Novel Approach ◽  
Language Pathology ◽  
The One ◽  
Critical Intervention ◽  
Reading And Spelling ◽  
Reading And Spelling Difficulties

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687

Abstract #709: E-Consults: A Novel Approach to Increase Access to Subspecialty Care in Endocrinology

2015 ◽  
Vol 21 ◽  
pp. 128
Author(s):  
Kaniksha Desai ◽  
Halis Akturk ◽  
Ana Maria Chindris ◽  
Shon Meek ◽  
Robert Smallridge ◽  
...  
Keyword(s):  
Novel Approach
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