Gate type selection based on fuzzy mapping

2002 ◽  
Vol 15 (01) ◽  
pp. 31
Author(s):  
Yu Wang
Keyword(s):  
Fuzzy Mapping ◽  
Type Selection

FUZZY MAPPING

1981 ◽  
Vol 1 (2) ◽  
pp. 145-155 ◽  
Author(s):  
Shih-pe Lou ◽  
Lichun Cheng
Keyword(s):  
Fuzzy Mapping

scholarly journals Variance analysis of immunoglobulin alleles in natural populations of rabbit (Oryctolagus cuniculus): the extensive interallelic divergence at the b locus could be the outcome of overdominance-type selection.

Genetics ◽  
1993 ◽  
Vol 135 (1) ◽  
pp. 171-187 ◽  
Author(s):  
W van der Loo
Keyword(s):  
Heavy Chain ◽  
Light Chain ◽  
Gene Diversity ◽  
Natural Populations ◽  
Constant Region ◽  
Immunoglobulin Light Chain ◽  
Evolutionary Patterns ◽  
B Locus ◽  
Type Selection ◽  
Predominant Allele

Abstract Population genetic data are presented which should contribute to evaluation of the hypothesis that the extraordinary evolutionary patterns observed at the b locus of the rabbit immunoglobulin light chain constant region can be the outcome of overdominance-type selection. The analysis of allele correlations in natural populations revealed an excess of heterozygotes of about 10% at the b locus while heterozygote excess was not observed at loci determining the immunoglobulin heavy chain. Data from the published literature, where homozygote advantage was suggested, were reevaluated and found in agreement with data here presented. Gene diversity was evenly distributed among populations and showed similarities with patterns reported for histocompatibility loci. Analysis of genotypic disequilibria revealed strong digenic associations between the leading alleles of heavy and light chain constant region loci in conjunction with trigenic disequilibria corresponding to a preferential association of b locus heterozygosity with the predominant allele of the heavy chain e locus. It is argued that this may indicate compensatory or nonadditive aspects of a putative heterozygosity enhancing mechanism, implying that effects at the light chain might be more pronounced in populations fixed for the heavy chain polymorphism.

scholarly journals BIOM-60. BIOMARKER EVALUATION FOR IMIPRIDONE ONC206 REVEALS ClpP, ATF4, MYC, EGFR and HIF1 AS KEY PREDICTORS OF ANTI-CANCER EFFICACY

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii14-ii15
Author(s):  
Sara Morrow ◽  
Mathew Garnett ◽  
Ultan McDermott ◽  
Cyril Benes ◽  
Joshua Allen ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Strong Predictor ◽  
Predictive Biomarkers ◽  
Receptor Expression ◽  
Tumor Type ◽  
Anticancer Efficacy ◽  
Type Selection ◽  
Egfr Expression ◽  
Transport Chain ◽  
Biomarker Evaluation

Abstract ONC206 is a DRD2 antagonist and ClpP agonist that is a chemical derivative of ONC201, which is in Phase II clinical trials for H3 K27M-mutant glioma. We have previously reported that dopamine receptor expression correlates with ONC201 and ONC206 efficacy. Here, we evaluated additional predictive biomarkers for both agents in the GDSC panel using RNA-seq expression data. ClpP emerged as a strong predictor of efficacy for ONC206 (IC50: p = 1.83E-4, AUC: 9.92E-13). ClpP activation enhances degradation of its substrates, including electron transport chain members responsible for oxidative phosphorylation (OXPHOS). Imipridones activate the integrated stress response involving ATF4 and cause proteasomal degradation of c-myc, which also reduces OXPHOS. Accordingly, high ATF4 (IC50: p = 4.92E-5, AUC: p=2.84E-9) and elevated c-myc correlated with ONC206 efficacy (IC50: p = 6.42E-6, AUC: 3.31E-12). EGFR expression is inversely correlate with DRD2 expression in glioma and its activation is associated with glycolysis. Low EGFR expression correlated with increased ONC206 efficacy (IC50: p = 4.32E-7, AUC: p = 6.44E-20). Loss of HIF1 shunts cellular metabolism toward OXPHOS. Low HIF1 expression correlated with increased anticancer efficacy for ONC206 (IC50: p = 1.96E-3, AUC: p = 1.56E-11). Expression of each of the five markers was significantly different in cell lines that achieved an IC90 with ONC206 (~10%) versus those that did not. A similar analysis for ONC201 revealed that ClpP, MYC and EGFR are more predictive of efficacy relative to ATF4 and HIF1. Combinatorial biomarker analyses revealed MYC/EGFR as the most significant predictor of IC50 for both agents. ClpP/MYC and ClpP/HIF1 were the most significant predictors of AUC for ONC201 and ONC206, respectively. Ongoing studies are further investigating tumor type enrichment of biomarkers. Prediction of innate imipridone sensitivity using biomarkers identified in this study may guide patient and tumor type selection in clinical trials.

A fuzzy mapping method for Kansei needs interpretation considering the individual Kansei variance

2021 ◽  
Author(s):  
Yuanfa Dong ◽  
Rongzhen Zhu ◽  
Wei Peng ◽  
Qihua Tian ◽  
Gang Guo ◽  
...  
Keyword(s):  
Mapping Method ◽  
Fuzzy Mapping ◽  
The Individual

scholarly journals How to Prevent Peritoneal Dialysis Catheter Tip Migration: A Japanese Perspective

2021 ◽  
Vol 1 (1) ◽  
pp. 29-34
Author(s):  
Minoru Ito ◽  
Masataka Koshika
Keyword(s):  
Peritoneal Dialysis ◽  
Successful Outcome ◽  
Peritoneal Dialysis Catheter ◽  
Common Complication ◽  
Type Selection ◽  
Catheter Malfunction ◽  
Peritoneal Wall ◽  
Catheter Tip ◽  
Catheter Complications ◽  
Japanese Perspective

The prevention of peritoneal dialysis (PD) catheter complications is essential to achieve a successful outcome. In recent years, nephrologists have performed more PD catheter insertion surgeries in Japan. The prevention of catheter complications is crucial for nephrologists who do not have all-around surgical skills. PD catheter tip migration is a common complication and a significant cause of catheter malfunction. Several preventive techniques have been reported for the PD catheter tip migration. This perspective described the following: (1) surgical technique in laparotomy, (2) laparoscopic surgery, (3) peritoneal wall anchor technique, and (4) catheter type selection. We hope that more effective methods of preventing catheter complications will be developed to ensure the success of PD treatment.

CAR T cell research has quickly advanced from the bench to the clinic and back. The results of the trials have revealed new mechanisms

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
T Cell ◽  
Cell Type ◽  
Signaling Systems ◽  
Car T Cell ◽  
Type Selection ◽  
Car T ◽  
Trial Outcomes

CAR T cell research has fast progressed into the clinic and now back to the bench, with trial outcomes exposing new mechanisms of efficacy, toxicity, and resistance, and sparking the hunt for additional targets, clarification of signaling systems, and application of newer technology. CAR design, transduction methods, and cell type selection are all predicted to improve responses and change therapy for patients with a variety of malignancies.

Basking Site Selection and Usage Strategies of the European Pond Turtle, Emys orbicularis (Linnaeus, 1758) in Babat valley (Gödöllő, Hungary)

2021 ◽  
Vol 28 (4) ◽  
pp. 175-184
Author(s):  
Gergő Erdélyi ◽  
Borbála Szabó ◽  
István Kiss
Keyword(s):  
Site Selection ◽  
Habitat Characteristics ◽  
Freshwater Turtles ◽  
Emys Orbicularis ◽  
Pond Turtle ◽  
Site Type ◽  
Type Selection ◽  
Body Sizes ◽  
Negative Effect ◽  
Selection Of

Sun basking is the most common method for freshwater turtles, such as the European pond turtle, to maintain optimal body temperature. The attributes of the macro- and microhabitat features around the basking sites affect the basking site selection of the European pond turtle. To protect the European pond turtle, it is important to know the basking habits among the biological characteristics of the species, along with the effects of the habitat characteristics and the choice of the type of basking sites. The purpose of our research was to detect the effects of macro- and microhabitat features on the selection of basking sites. We wanted to determine basking site type selection according to the carapace length classes and if there is any difference in the choice of basking trunks and branches with different thicknesses. Turtles choose basking sites with less closed vegetation in their environment. We have detected seasonal differences in the microhabitat features. The closing reed and Typha sp. had a negative effect on the number of observed basking turtles. The most popular type of basking sites in the pond system was the commonly occurred fallen tree trunks and branches in the water, regardless of turtle body size. Most turtles used thinner tree trunks and branches for basking. In the meantime, we found differences in the choice of basking trunks between the turtles with different body sizes. Younger turtles with smaller bodies appeared in larger numbers on emergent branches with smaller diameters.

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