scholarly journals Functional Polymorphisms of the Coagulation Factor II Gene (F2) and Susceptibility to Systemic Lupus Erythematosus

2011 ◽  
Vol 38 (4) ◽  
pp. 652-657 ◽  
Author(s):  
F. YESIM K. DEMIRCI ◽  
AMY S. DRESSEN ◽  
CANDACE M. KAMMERER ◽  
M. MICHAEL BARMADA ◽  
AMY H. KAO ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
African Americans ◽  
Allele Frequency ◽  
Lupus Erythematosus ◽  
Coagulation Factor ◽  
Systemic Lupus ◽  
Vascular Events ◽  
Functional Polymorphisms ◽  
Caucasian Americans ◽  
Activity Measurements

Objective.TwoF2functional polymorphisms, rs1799963 (G20210A) and rs3136516 (A19911G), are known to be associated with elevated levels/activity of prothrombin (encoded byF2) and risk of thrombosis. Since patients with systemic lupus erythematosus (SLE) have high risk of thrombosis and accelerated atherosclerosis and also high prevalence of anti-prothrombin antibodies, we hypothesized that these twoF2polymorphisms could affect risk of SLE.Methods.We investigated these polymorphisms in 627 women with SLE (84% Caucasian Americans, 16% African Americans) and 657 female controls (78% Caucasian Americans, 22% African Americans).Results.While the rs1799963 A allele was almost absent in African Americans, it was present at ∼2% frequency in Caucasian Americans and showed no significant association with SLE. The rs3136516 G allele frequency was significantly higher in Caucasian SLE cases than in controls (48.4% vs 43.7%, respectively) with a covariate-adjusted odds ratio (OR) of 1.22 (95% CI 1.03–1.46, p = 0.023). The association was replicated in African Americans (rs3136516 G allele frequency 91.2% in cases vs 82.2% in controls) with an adjusted OR of 1.96 (95% CI 1.08–3.58, p = 0.022). Stratification of Caucasian SLE patients based on the presence or absence of cardiac and vascular events (CVE) revealed stronger association with the CVE-positive SLE subgroup than the CVE-negative SLE subgroup (OR 1.42 vs 1.20). Prothrombin activity measurements in a subset of SLE cases demonstrated higher activity in the carriers of the rs3136516 G allele.Conclusion.Our results suggest a potential role for prothrombin and the crosstalk between hemostatic and immune/inflammatory systems in SLE and SLE-associated cardiovascular events, which warrants further investigation in independent samples.

scholarly journals Systemic lupus erythematosus in a multiethnic US cohort (LUMINA): XXIII. Baseline predictors of vascular events

2004 ◽  
Vol 50 (12) ◽  
pp. 3947-3957 ◽  
Author(s):  
Sergio M. A. Toloza ◽  
América G. Uribe ◽  
Gerald McGwin ◽  
Graciela S. Alarcón ◽  
Barri J. Fessler ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Vascular Events

Vascular events in hypertensive patients with systemic lupus erythematosus

Lupus ◽  
2000 ◽  
Vol 9 (9) ◽  
pp. 672-675 ◽  
Author(s):  
P Rahman ◽  
S Aguero ◽  
D D Gladman ◽  
D Hallett ◽  
M B Urowitz
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Vascular Events ◽  
Hypertensive Patients

Abstract 05: Race and Hospitalization for Cardiovascular Disease in Patients With Systemic Lupus Erythematosus

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Meghan Angley ◽  
Tene T Lewis ◽  
Penelope P Howards ◽  
Sung Lim
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cardiovascular Disease ◽  
African Americans ◽  
Lupus Erythematosus ◽  
Survival Curve ◽  
Population Based ◽  
Systemic Lupus ◽  
Time To Event Data ◽  
Artery Disease ◽  
Stratified Analysis

Background: Patients diagnosed with systemic lupus erythematosus (SLE) are at greater risk of cardiovascular disease (CVD) and death at earlier ages than the general population, with African Americans (AA) at risk at earlier ages than non-AAs. However, the association between race and recurrent hospitalizations for CVD, which are associated with mortality, has not been explored. Methods: The Georgia Lupus Registry (GLR) is a population-based registry of individuals with SLE in 2002-2004 in Atlanta, Georgia. Both incident and prevalent cases were enrolled, and we included all cases diagnosed beginning in 2000. The GLR was matched to Georgia inpatient hospital discharge records from 2000-2013. Using ICD-9-CM codes, we identified hospitalizations classified as having coronary heart disease, peripheral artery disease, cerebrovascular disease or heart failure. The Prentice-Williams-Peterson Model with a total time scale measured from diagnosis was used to examine recurrent time to event data. We truncated the number of hospitalizations at 3 to maintain stable modeling estimates. Patients were censored at the time of death or at the end of 2013. Models were adjusted for sex and age at diagnosis. Results: A total of 556 participants in the GLR (87% female, 73% AA) had a median age at SLE diagnosis of 38 years and 27% experienced at least 1 CVD hospitalization, while 17% experienced ≥ 2. Overall, AA race was associated with recurrent hospitalizations (adjusted hazard ratio [aHR]: 1.7, 95% confidence interval [CI]: 1.2, 2.3). In an event-specific stratified analysis, the association between AA race and the hazard of recurrence became even more pronounced in later events (Event 1 aHR: 1.2, 95% CI: 1.0, 1.5; Event 2 aHR: 1.5, 95% CI: 1.2, 2.2; Event 3 aHR: 1.9, 95% CI: 1.1, 3.2). Conclusions: African-Americans with SLE were more likely to experience recurrent hospitalizations for CVD than their non-AA counterparts, suggesting that AA individuals with SLE may be more vulnerable to CV complications of SLE. Figure 1. Survival curve for 1st event

scholarly journals Impact of the new American College of Cardiology/American Heart Association definition of hypertension on atherosclerotic vascular events in systemic lupus erythematosus

2020 ◽  
Vol 79 (5) ◽  
pp. 612-617 ◽  
Author(s):  
Konstantinos Tselios ◽  
Dafna D Gladman ◽  
Jiandong Su ◽  
Murray Urowitz
Keyword(s):  
Risk Factors ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
American Heart Association ◽  
American Heart ◽  
Heart Association ◽  
Cerebrovascular Event ◽  
Systemic Lupus ◽  
Vascular Events

BackgroundThe 2017 American College of Cardiology/American Heart Association guidelines defined hypertension at ≥130/80 mm Hg. Studies on patients with connective tissue diseases were not considered. Our aim was to assess the impact of this definition on atherosclerotic vascular events (AVEs) in systemic lupus erythematosus.Patients methodsIndividuals from the Toronto Lupus Clinic with at least 2 years of follow-up and no prior AVE were divided in three groups according to their mean blood pressure (BP) over that period (≥140/90 mm Hg, 130-139/80-89 mm Hg and <130/80 mm Hg). They were followed until the first occurrence of an AVE (fatal or non-fatal coronary artery disease, cerebrovascular event and peripheral vascular disease) or last visit. Groups were compared as per the baseline atherosclerotic risk factors. A multivariable time-dependent analysis was performed to adjust for the presence of other risk factors.ResultsOf 1532 patients satisfying the inclusion criteria, 155 (10.1%) had a BP ≥140/90 mm Hg, 316 (20.6%) 130–139/80–89 mm Hg and 1061 (69.3%) were normotensives. After a mean follow-up of 10.8 years, 124 AVEs were documented. The incidence rates were 18.9, 11.5 and 4.5 per 1000 patient-years for the three groups, respectively (p=0.0007 between the 130–139/80–89 mm Hg group and the normotensives). A mean BP of 130–139/80–89 mm Hg over the first 2 years was independently associated with the occurrence of AVEs (HR 1.73, 95% CI 1.13 to 2.65, p=0.011).ConclusionPatients with lupus with a sustained mean BP of 130–139/80–89 mm Hg over 2 years had a significantly higher incidence of AVEs compared with normotensive individuals. This BP level should be the target for antihypertensive therapy to minimise their cardiovascular risk.

scholarly journals Functional polymorphisms in pre-miR146a and pre-miR499 are associated with systemic lupus erythematosus but not with rheumatoid arthritis or Graves’ disease in Mexican patients

Oncotarget ◽  
2017 ◽  
Vol 8 (54) ◽  
pp. 91876-91886 ◽  
Author(s):  
Isidro Alemán-Ávila ◽  
Mayra Jiménez-Morales ◽  
Olga Beltrán-Ramírez ◽  
Rosa Elda Barbosa-Cobos ◽  
Silvia Jiménez-Morales ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Graves Disease ◽  
Systemic Lupus ◽  
Functional Polymorphisms ◽  
Mexican Patients

scholarly journals Accrual of Atherosclerotic Vascular Events in a Multicenter Inception Systemic Lupus Erythematosus Cohort

2020 ◽  
Vol 72 (10) ◽  
pp. 1734-1740 ◽  
Author(s):  
Murray B. Urowitz ◽  
Dafna D. Gladman ◽  
Vernon Farewell ◽  
Jiandong Su ◽  
Juanita Romero-Diaz ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Vascular Events
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