Relationship Between Low Bone Mineral Density and Varus Deformity in Postmenopausal Women with Knee Osteoarthritis

2009 ◽  
Vol 36 (3) ◽  
pp. 592-597 ◽  
Author(s):  
YASUSHI AKAMATSU ◽  
NAOTO MITSUGI ◽  
NAOYA TAKI ◽  
RYOHEI TAKEUCHI ◽  
TOMOYUKI SAITO
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Knee Osteoarthritis ◽  
Structural Changes ◽  
Tibial Plateau ◽  
Varus Deformity ◽  
Varus Knee ◽  
Mineral Density ◽  
Femorotibial Angle ◽  
Knee Oa

Objective.To assess the relationship between bone mineral density (BMD) and varus deformity arising from bone structural changes caused by knee osteoarthritis (OA) in postmenopausal women.Methods.This cross-sectional study involved 135 consecutive postmenopausal female patients who had varus knee OA and a Kellgren-Lawrence grade ≥ 2. Knee radiographs were obtained with the patient standing on one leg, and subjects were classified into 3 tertile groups according to femorotibial angle, which was taken as a measure of varus knee OA severity. We also measured the 3 subangles that make up the femorotibial angle, and focused on the varus inclination of the tibial plateau. BMD was measured in the lumbar spine, femoral neck, and medial and lateral tibial condyles using dual-energy X-ray absorptiometry. Differences between femorotibial angle tertile groups were assessed, and associations between femorotibial sub-angles and BMD values at various points were evaluated.Results.After adjustment for age and body mass index, there was no significant association between the varus inclination of the tibial plateau and lumbar spine BMD. A weak but statistically significant negative correlation existed between varus inclination of the tibial plateau and BMD at the ipsilateral proximal femur and lateral tibial condyle.Conclusion.Varus inclination of the tibial plateau was significantly more severe in the femorotibial angle tertile 3 group, and in patients with lower BMD in the ipsilateral lower limb. Varus knee OA may result not only from cartilage loss but also from structural changes of the bone.

scholarly journals BONE MINERAL DENSITY AND TRABECULAR BONE SCORE IN POSTMENOPAUSAL WOMEN WITH KNEE OSTEOARTHRITIS AND OBESITY

2020 ◽  
Vol 73 (3) ◽  
pp. 529-533
Author(s):  
Vladyslav V. Povoroznyuk ◽  
Nataliia V. Zaverukha ◽  
Anna S. Musiienko
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Femoral Neck ◽  
Knee Osteoarthritis ◽  
Postmenopausal Women ◽  
Trabecular Bone Score ◽  
Mineral Density ◽  
Knee Oa ◽  
Symptomatic Knee ◽  
Normal Functional

The aim of the study was to investigate the relationship between bone mineral density (BMD) of lumbar spine, femoral neck, trabecular bone score (TBS) and body mass index (BMI), in postmenopausal women with knee osteoarthritis (OA). Materials and methods: The study group comprised 359 postmenopausal women aged 50-89 years. They were divided into 2 groups: I group – 117 postmenopausal women with symptomatic knee OA and II group –242 women with a normal functional activity of knee joints. Analysis of data was performed taking into account their BMD of lumbar spine (L1-L4) and femoral neck, measured by the Dual-energy X-ray absorptiometry (DXA) Hologic (Discovery WI, USA, 2016). TBS of L1-L4 was detected by TBS insight® software (MedImaps, Pessac, France), and BMI classified by World Health Organization (WHO). Results: In postmenopausal women with obesity prevalence of symptomatic knee OA was detected in 41.1% of cases. However, in women with normal BMI knee OA was revealed in 29.0% of women. The highest level of knee OA in obese women aged 70-79 years – 45.8%. According to a chi-squared (χ2) test, a significantly higher level of BMI was detected in postmenopausal women with OA (χ2=5.05, p=0.02). Conclusion: Women with a symptomatic OA had a significantly higher BMD of lumbar spine compared with women who had a normal functional activity of knee. Significant negative correlation were detected between TBS and BMI, and significant positive correlations between lumbar spine BMD and BMI.

scholarly journals Relationship between shaft bowing in the femur and tibia and bone mineral density in women with varus knee osteoarthritis

2012 ◽  
Vol 20 ◽  
pp. S219 ◽  
Author(s):  
Y. Akamatsu ◽  
N. Mitsugi ◽  
H. Kobayashi ◽  
K. Kumagai ◽  
Y. Kusayama ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Knee Osteoarthritis ◽  
Bone Mineral ◽  
Varus Knee ◽  
Mineral Density

scholarly journals Interrelation of bone mineral density with kneeosteoarthrosis

2011 ◽  
Vol 14 (1) ◽  
pp. 19-20
Author(s):  
E. M. Zaytseva ◽  
A. V. Smirnov ◽  
L. I. Alekseeva ◽  
E. M. Zaitseva ◽  
A. V. Smirnov ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Disease Onset ◽  
Axial Skeleton ◽  
Knee Joints ◽  
Mineral Density ◽  
X Ray ◽  
Knee Oa ◽  
Early Oa

Association of bone mineral density (BMD) of axial skeleton with age of the disease onset as well as with clinical traits and instrumental investigation findings has been studied in osteoarthritic patients. 116 females with primary knee OA, 74 ofwhich exhibited normal or increased BMD at lumbar spine and 42, with osteoporosis were included in the study. Knee joint pain was measured using visual analog scale (VAS). All the patients were subjected to X-ray analysis of their knee joints at two sites (OA stage was determined according to Kellgren-Lawrence scale), densitometry at lumbar spine and proximal femur using QDR-4500W (Hologic), MRT, and ultrasonography of the knee joints. We determined that the increasedBMD at lumbar spine was associated with early OA onset, more pronounced X-ray changes in the knee joints and higher frequency of varus deformation development in tibial bones.

scholarly journals Correlation Between Weight Bearing Asymmetry and Bone Mineral Density in Patients With Bilateral Knee Osteoarthritis

2021 ◽  
Author(s):  
Kohei Nishizawa ◽  
Kengo Harato ◽  
Yutaro Morishige ◽  
Shu Kobayashi ◽  
Yasuo Niki ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Clinical Data ◽  
Weight Bearing ◽  
Mineral Density ◽  
Femorotibial Angle ◽  
Knee Oa ◽  
Bilateral Knee ◽  
Gait Parameters ◽  
The Relationship

Abstract Background: Although unloading of the joint is related to reduction of the local bone mineral density (BMD), little attention had been paid to the relationship between loading asymmetry and side-to-side difference of BMD in patients with bilateral knee osteoarthritis (OA). The aim of the present study was to evaluate and clarify the relationship between gait parameters and bone mineral density in those patients.Methods: A total of 36 knees in eighteen patients (mean age = 73.7 ± 6.3 years, mean body mass index = 26.7 ± 3.8 kg/m2) with bilateral medial knee OA were enrolled in the present study. All subjects performed relaxed standing and level walking at our gait laboratory after informed consent was obtained. First, ground reaction force was calculated on bilateral knees during standing. The knees in each patient were divided into Higher and Lower force side for the definition of dominant side limb. Second, gait parameters in each subject were obtained. To analyze the factors that affect the weight bearing distribution in both limbs, clinical data and biomechanical parameters were compared between knees. Clinical data included radiographic OA grade, femorotibial angle and BMD at the bilateral femoral neck.Results: Knees on Higher force side were significantly more extended than on Lower force side in standing (P=0.012) and knee excursion during weight acceptance phase in gait was significantly larger in Higher side than in Lower side (P=0.006), while the other parameters were not significantly different. As to the clinical data, Higher force side had greater BMD, compared to Lower force side. In terms of Kellgren-Lawrence scale and femorotibial angle on plain radiographs, there were no significant differences between Higher and Lower force side.Conclusions: Based on loading asymmetry in the present study, lower BMD was observed on Lower force side in patients with knee OA. Therefore, it is helpful for orthopedic surgeons to examine side-to-side differences of bone mineral density or extension limitation during standing for evaluation of the loading condition in patients with bilateral knee OA.

scholarly journals Bone mineral density in elderly and senile women with knee and hip osteoarthritis

2020 ◽  
Vol 14 (1) ◽  
pp. 62-66
Author(s):  
Yu. V. Averkieva ◽  
I. I. Grigorieva ◽  
T. A. Raskina
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Age Groups ◽  
Hip Osteoarthritis ◽  
Stage I ◽  
Mineral Density ◽  
Knee Oa ◽  
Lower Lumbar Spine

Objective: to study bone mineral density (BMD) in elderly and senile women with knee and hip osteoarthritis (OA).Patients and methods. The investigation enrolled 124 women (mean age, 73.3±8.46 years) diagnosed with OA meeting the ACR diagnostic criteria. Lumbar spine (LI-IV) and femoral neck BMD values were determined; knee and hip X-ray in the frontal projection was carried out to assess the radiographic stage according to the Kellgren and Lawrence classification.Results and discussion. The overall incidence of osteoporosis (OP) and ostopenia in the study cohort was 28 and 41%, respectively. OP was diagnosed in 20% of women aged 60–74 years and in 38% of those aged 75–90 years (p<0.05); osteopenia was in 41 and 42%, respectively (p>0.05). In the age groups of 65–74 years and ≥75 years, women with stage III–IV hip OA had a significantly higher femoral neck BMD than those with Stage I–II (p<0.05). At the same time, the later radiographic stages of hip OA were associated with lower lumbar spine BMD (p<0.05). The patients of both age groups who had Stages III and IV knee OA had a significantly higher lumbar spine BMD than those with Stage I–II OA (p<0.05). The femoral neck BMD in patients with Stages I–II and III–IV knee OA was comparable in both age groups (p>0.05).Conclusion. The relationship between BMD and OA-related structural changes is contradictory and requires further investigation. 

scholarly journals Correlation between weight-bearing asymmetry and bone mineral density in patients with bilateral knee osteoarthritis

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Kohei Nishizawa ◽  
Kengo Harato ◽  
Yutaro Morishige ◽  
Shu Kobayashi ◽  
Yasuo Niki ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Clinical Data ◽  
Weight Bearing ◽  
Mineral Density ◽  
Femorotibial Angle ◽  
Knee Oa ◽  
Bilateral Knee ◽  
Gait Parameters ◽  
The Relationship

Abstract Background Although unloading of the joint is related to reduction of the local bone mineral density (BMD), little attention had been paid to the relationship between loading asymmetry and side-to-side difference of BMD in patients with bilateral knee osteoarthritis (OA). The aim of the present study was to evaluate and clarify the relationship between gait parameters and bone mineral density in those patients. Methods A total of 36 knees in eighteen patients (mean age = 73.7 ± 6.3 years, mean body mass index = 26.7 ± 3.8 kg/m2) with bilateral medial knee OA were enrolled in the present study. All subjects performed relaxed standing and level walking at our gait laboratory after informed consent was obtained. First, ground reaction force was calculated on bilateral knees during standing. The knees in each patient were divided into higher and lower force side for the definition of dominant side limb. Second, gait parameters in each subject were obtained. To analyze the factors that affect the weight-bearing distribution in both limbs, clinical data and biomechanical parameters were compared between knees. Clinical data included radiographic OA grade, femorotibial angle, and BMD at the bilateral femoral neck. Results Knees on higher force side were significantly more extended than on lower force side in standing (P = 0.012) and knee excursion during weight acceptance phase in gait was significantly larger in higher side than in lower side (P = 0.006), while the other parameters were not significantly different. As to the clinical data, higher force side had greater BMD, compared to lower force side. In terms of Kellgren–Lawrence scale and femorotibial angle on plain radiographs, there were no significant differences between higher and lower force side. Conclusions Based on loading asymmetry in the present study, lower BMD was observed on Lower force side in patients with knee OA. Therefore, it is helpful for orthopedic surgeons to examine side-to-side differences of bone mineral density or extension limitation during standing for evaluation of the loading condition in patients with bilateral knee OA.

scholarly journals POS0045 LEAST SIGNIFICANT CHANGE IN BONE DENSITOMETRY IN PATIENTS WITH OBESITY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 227.2-228
Author(s):  
D. Claire ◽  
M. Geoffroy ◽  
L. Kanagaratnam ◽  
C. Isabelle ◽  
A. Hittinger ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
General Population ◽  
Bone Mineral ◽  
Bone Densitometry ◽  
Dual Energy ◽  
Mineral Density ◽  
Least Significant Change ◽  
X Ray ◽  
Significant Change

Background:Dual energy X-ray absoprtiometry is the reference method to mesure bone mineral density (1). Loss of bone mineral density is significant if it exceeds the least significant change. The threshold value used in general population is 0,03 g/cm2 (2). Patients with obesity are known for having a higher bone mineral density due to metabolism and physiopathology characteristics (3,4).Objectives:The aim of our study was to determine the least significant change in bone densitometry in patients with obesity.Methods:We conducted an interventionnal study in 120 patients with obesity who performed a bone densitometry. We measured twice the bone mineral density at the lumbar spine, the femoral neck and the total hip in the same time (5,6). We determined the least significant change in bone densitometry from each pair of measurements, using the Bland and Altman method. We also determined the least significant change in bone densitometry according to each stage of obesity.Results:The least significant change in bone densitometry in patients with obesity is 0,046g/cm2 at the lumbar spine, 0.069 g/cm2 at the femoral neck and 0.06 g/cm2 at the total hip.Conclusion:The least significant change in bone densitometry in patients with obesity is higher than in general population. These results may improve DXA interpretation in this specific population, and may personnalize their medical care.References:[1]Lees B, Stevenson JC. An evaluation of dual-energy X-ray absorptiometry and comparison with dual-photon absorptiometry. Osteoporos Int. mai 1992;2(3):146-52.[2]Briot K, Roux C, Thomas T, Blain H, Buchon D, Chapurlat R, et al. Actualisation 2018 des recommandations françaises du traitement de l’ostéoporose post-ménopausique. Rev Rhum. oct 2018;85(5):428-40.[3]Shapses SA, Pop LC, Wang Y. Obesity is a concern for bone health with aging. Nutr Res N Y N. mars 2017;39:1-13.[4]Savvidis C, Tournis S, Dede AD. Obesity and bone metabolism. Hormones. juin 2018;17(2):205-17.[5]Roux C, Garnero P, Thomas T, Sabatier J-P, Orcel P, Audran M, et al. Recommendations for monitoring antiresorptive therapies in postmenopausal osteoporosis. Jt Bone Spine Rev Rhum. janv 2005;72(1):26-31.[6]Ravaud P, Reny JL, Giraudeau B, Porcher R, Dougados M, Roux C. Individual smallest detectable difference in bone mineral density measurements. J Bone Miner Res. août 1999;14(8):1449-56.Disclosure of Interests:None declared.

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