Tendinous and Ligamentous Derangements in Systemic Lupus Erythematosus

2008 ◽  
Vol 35 (11) ◽  
pp. 2187-2191 ◽  
Author(s):  
GABRIELA SIERRA-JIMENEZ ◽  
ADRIANA SANCHEZ-ORTIZ ◽  
FRANCISCO JAVIER ACEVES-AVILA ◽  
GUILLERMO HERNANDEZ-RIOS ◽  
SERGIO DURÁN-BARRAGÁN ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Ct Scan ◽  
Lupus Erythematosus ◽  
Care Center ◽  
Tertiary Care ◽  
Radiographic Evaluation ◽  
Systemic Lupus ◽  
Osteitis Pubis ◽  
Common Framework ◽  
Grade Iii

ObjectiveWe assessed the prevalence of selected clinical and radiological features of tendinous and ligamentous derangements in a consecutive sample of patients with systemic lupus erythematosus (SLE).MethodsConsecutive patients with SLE with no comorbidities attending a tertiary care center were prospectively assessed and underwent plain radiographic evaluation of the pelvis. Radiographs were analyzed by 2 blinded observers; radiographic sacroiliitis was graded 0 to IV. To better assess sacroiliac (SI) involvement, a computed tomography (CT) scan of the SI joints was performed in patients with grade III sacroiliitis. Hip joints and pubis were also assessed as described.ResultsOf the 192 included patients, 89% were female, mean age was 36 years, and mean disease duration was 10 years. Inflammatory low back pain was reported by 10% of patients. Sacroiliitis of any grade was observed in 31 patients (16%), and grade III (confirmed on CT scan) sacroiliitis was observed in 6% (95% CI 3% to 9%). Osteitis pubis was diagnosed in 6% (95% CI 3% to 10%) and coxofemoral migration in 8% (95% CI 2% to 9%). Jaccoud’s arthropathy was found in 23%. Demographic and clinical variables were not statistically associated with radiographic sacroiliitis.ConclusionSacroiliitis and other tendinous and ligamentous derangements are not uncommon in patients with SLE. Based on these features and on previous reports, the term “SLE-related tendinous and ligamentous derangements” may be used to establish a common framework for further research and reporting.

Characteristics of lupus and lupus nephritis at a tertiary care center in Lebanon

Lupus ◽  
2019 ◽  
Vol 28 (13) ◽  
pp. 1598-1603 ◽  
Author(s):  
S H Koubar ◽  
J Kort ◽  
S Kawtharani ◽  
M Chaaya ◽  
M Makki ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Kidney Disease ◽  
Complete Remission ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Partial Remission ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Systemic Lupus

Introduction Systemic lupus erythematosus affects 4.8–78.5 people per 100,000 worldwide, 90% of whom are females. Geography and ethnicity have been shown to significantly affect the prevalence and natural history of the disease. Lupus nephritis affects around half of patients with systemic lupus erythematosus. Data about systemic lupus erythematosus and lupus nephritis in the Middle East are still scarce. In this study, we aimed to describe the characteristics of systemic lupus erythematosus and lupus nephritis at a tertiary care center in Lebanon. Methods This is a retrospective chart review of all biopsy-proven lupus nephritis patients admitted to the American University of Beirut medical center between January 2000 and December 2018. Patients above 12 years of age who had any International Society of Nephrology/Renal Pathology Society (ISN/RPS) class of lupus nephritis on their renal biopsy were included in the study. Results The study included 55 patients with lupus nephritis. Upon presentation of systemic lupus erythematosus, the most common clinical feature was arthritis, seen in 83% of patients, followed by anemia (82%) and malar rash (48%). In total 93% had positive ANA, 89% had positive anti-dsDNA and 98% of patients had proteinuria. The most common ISN/RPS class of lupus nephritis in our series was IV (49%). At the time of the biopsy 15% of patients underwent dialysis. At 6 months, 11/27 had complete remission, 6/27 had partial remission and 10/27 had no remission. At 1 year, 8/23 had complete remission, 4/23 had partial remission and 11/23 had no remission. During the study period, 15 out of 35 patients available for analysis had chronic kidney disease (CKD) and six out of 34 patients developed end-stage kidney disease requiring renal replacement therapy. In comparison to other series in the region, our series had more males affected, higher creatinine at the time of biopsy and greater degree of proteinuria. Conclusion Our study provided insight on the demographics, characteristics, and outcomes of lupus nephritis in Lebanon. Interestingly, male gender was present in a quarter of patients. This warrants further investigation and confirmation. We are hoping to expand this experience into a national prospective registry to further characterize this entity in our region.

scholarly journals Prevalence of systemic lupus erythematosus among patients of hypothyroidism in a tertiary care center

2012 ◽  
Vol 16 (4) ◽  
pp. 569 ◽  
Author(s):  
Kaushik Pandit ◽  
Rudrajit Paul ◽  
PradipKumar Sinha ◽  
Pradip Raychaudhuri ◽  
Sekhar Mookerjee ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Systemic Lupus

scholarly journals A STUDY OF CLINICAL AND LABORATORY PROFILE OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AT A TERTIARY CARE CENTER IN WESTERN INDIA

2021 ◽  
pp. 1-2
Author(s):  
Seema Sharma ◽  
Shivani A Patel ◽  
Shivam N Shah ◽  
Mauli P Vora
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Care Center ◽  
Tertiary Care ◽  
Western India ◽  
Systemic Lupus ◽  
Multisystem Disease ◽  
Initial Manifestation ◽  
Cross Sectional ◽  
Laboratory Profile

Aim: To study the clinical and laboratory profile of patients having systemic lupus erythematosus (SLE) at Civil Hospital, Ahmedabad. SLE is an autoimmune multisystem disease which mainly affects young females in their child bearing age leading to decreased productivity and increased economic burden Methods: -Type of study: Cross sectional study. Patients fulfilling revised American College of Rheumatology criteria (1982) for SLE were included in the study. Detailed history, clinical examination and laboratory results of the patients were noted. Data analysis was carried out using Statistical Package for Social Sciences. Results: 25 patients were enrolled in the study. Females (84%) were more commonly affected, maximum patients being in the age group of 20 – 30 years. Arthritis was amongst the commonest initial manifestation (84%) followed by anemia (76%). Other manifestations included involvement of Renal, Cardiopulmonary, Dermatologic and Nervous System. ANA antibody was found positive in all patients while anti dsDNA was positive in 80% patients. Conclusion: The incidence of anemia and lupus nephritis was higher in our study as compared to other studies. Early intervention and close follow up is vital to prevention of morbidity and mortality. Arthritis and Anemia were amongst the most common clinical features.

scholarly journals Identification of patient subsets among those presumptively diagnosed with, referred, and/or followed up for systemic lupus erythematosus at a large tertiary care center

1995 ◽  
Vol 38 (10) ◽  
pp. 1475-1484 ◽  
Author(s):  
Jaime Calvo-Alén ◽  
Holly M. Bastian ◽  
Karin V. Straaton ◽  
Sheila L. Burgard ◽  
Isis S. Mikhail ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Systemic Lupus ◽  
Large Tertiary Care

scholarly journals Complete Congenital Heart Block in a Newborn Associated with Maternal Systemic Lupus Erythematosus: A Case Report

2013 ◽  
Vol 1 (3) ◽  
pp. 128-131
Author(s):  
Mahmoud A. Kiblawi ◽  
Alina Naeem ◽  
Elham A. Al Attrash ◽  
Subhranshu Kar ◽  
B. K. M. Goud
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Lupus Erythematosus ◽  
Heart Block ◽  
Congenital Heart ◽  
Care Center ◽  
Tertiary Care ◽  
Congenital Heart Block ◽  
Structural Abnormality ◽  
Systemic Lupus

Background: Complete Congenital Heart Block (CCHB) is a rare disease of the newborn that carries significant morbidity and mortality. CCHB can be diagnosed early or late in life. In newborns, it is usually associated with maternal autoantibodies or a congenital cardiac structural abnormality. The most common presentation of CCHB is bradycardia that can be diagnosed by an electrocardiogram. Results: This is a case report of a male infant born to a mother with an autoimmune disease, Systemic Lupus Erythematosus (SLE), who was found to have third degree heart block at birth. Conclusion: Early diagnosis and prompt management of the case is important for a better prog­nosis and prevention of associated complications. Neonates with CCHB should be managed at a tertiary care center and the only definite treatment is insertion of a pacemaker. Moreover, prenatal diagnosis and specific obstetric counseling of pregnant women with SLE along with careful monitoring with serial ultrasonography and echocardiography are of paramount importance in prevention of the disease in subsequent offspring.

Pneumonia in patients with systemic lupus erythematosus: Epidemiology, microbiology and outcomes

Lupus ◽  
2018 ◽  
Vol 27 (12) ◽  
pp. 1953-1959 ◽  
Author(s):  
G García-Guevara ◽  
R Ríos-Corzo ◽  
A Díaz-Mora ◽  
M López-López ◽  
J Hernández-Flores ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Poor Prognosis ◽  
Care Center ◽  
Tertiary Care ◽  
Multivariable Analysis ◽  
Pneumonia Severity Index ◽  
Composite Outcome ◽  
Systemic Lupus

Background and objective Pneumonia remains the main cause of mortality in patients with systemic lupus erythematosus (SLE). The aim of the study was to establish the clinical characteristics, microbiology and risk factors for poor prognosis in patients with SLE and pneumonia. Methods We reviewed medical records of patients with SLE (American College of Rheumatology criteria) and pneumonia who attended the emergency room in a single tertiary care center (January 2010–March 2015). We collected demographics, treatment and disease activity (SLEDAI-2K) data. Severity scales of pneumonia (CURB-65 (acronym for risk factors measured: confusion, urea nitrogen, respiratory rate, blood pressure, 65 years of age and older) and Pneumonia Severity Index (PSI)) were obtained. A negative composite outcome was defined as need for mechanical ventilation, septic shock or death secondary to pneumonia up to 30 days after discharge. We conducted a univariate and multivariable analysis. Results We studied 158 patients (76% women) with 187 episodes of pneumonia. There were no differences in age, SLE duration, SLE activity, treatment or comorbidities between patients with negative composite outcome vs the other group. In 53 episodes, patients presented with a negative composite outcome. Of these, 46 (24.6%) required intubation, 13 (7%) developed shock and 12 (6.4%) died. The most common bacteria isolated was S. aureus, and we observed a high percentage of nonhabitual microorganisms. Fifteen percent of patients who presented with a negative outcome had low values on CURB-65 and PSI scales. Conclusion Patients with SLE and pneumonia have a high risk of complications and present with a high percentage of nonhabitual microorganisms. Severity scales for pneumonia can misclassify as low risk SLE patients with poor prognosis.

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