scholarly journals R-etodolac induces E-cadherin and suppresses colitis-related mouse colon tumorigenesis

2010 ◽  
Vol 24 (6) ◽  
Author(s):  
Murano
Keyword(s):  
Colon Tumorigenesis ◽  
Mouse Colon ◽  
E Cadherin

Abstract 1432: Tnfα ablation demonstrates no suppressive effect on inflammation-related mouse colon tumorigenesis

2010 ◽  
Author(s):  
Hiroyasu Sakai ◽  
Yasuhiro Yamada ◽  
Masahito Shimizu ◽  
Hisataka Moriwaki ◽  
Akira Hara
Keyword(s):  
Suppressive Effect ◽  
Colon Tumorigenesis ◽  
Mouse Colon

Genetic ablation of Tnfα demonstrates no detectable suppressive effect on inflammation-related mouse colon tumorigenesis

2010 ◽  
Vol 184 (3) ◽  
pp. 423-430 ◽  
Author(s):  
Hiroyasu Sakai ◽  
Yasuhiro Yamada ◽  
Masahito Shimizu ◽  
Kuniaki Saito ◽  
Hisataka Moriwaki ◽  
...  
Keyword(s):  
Suppressive Effect ◽  
Genetic Ablation ◽  
Colon Tumorigenesis ◽  
Mouse Colon

Su2023 The Dipeptidyl Peptidase-4 Inhibitor, Sitagliptin, Suppresses Mouse Colon Tumorigenesis in Type 2 Diabetes Mice

2015 ◽  
Vol 148 (4) ◽  
pp. S-577
Author(s):  
Naoki Yorifuji ◽  
Takuya Inoue ◽  
Kaori Fujiwara ◽  
Munetaka Iguchi ◽  
Yuichi Kojima ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase 4 ◽  
Colon Tumorigenesis ◽  
Mouse Colon ◽  
Diabetes Mice ◽  
Dipeptidyl Peptidase 4 Inhibitor

Differential Expression of p16INK4a in Azoxymethane-Induced Mouse Colon Tumorigenesis

2000 ◽  
Vol 28 (3) ◽  
pp. 139-147 ◽  
Author(s):  
Qian-Shu Wang ◽  
Alexandros Papanikolaou ◽  
Prashant R. Nambiar ◽  
Daniel W. Rosenberg
Keyword(s):  
Differential Expression ◽  
Colon Tumorigenesis ◽  
Mouse Colon

scholarly journals The dipeptidyl peptidase-4 inhibitor sitagliptin suppresses mouse colon tumorigenesis in type 2 diabetic mice

2015 ◽  
Vol 35 (2) ◽  
pp. 676-682 ◽  
Author(s):  
NAOKI YORIFUJI ◽  
TAKUYA INOUE ◽  
MUNETAKA IGUCHI ◽  
KAORI FUJIWARA ◽  
KAZUKI KAKIMOTO ◽  
...  
Keyword(s):  
Dipeptidyl Peptidase ◽  
Diabetic Mice ◽  
Dipeptidyl Peptidase 4 ◽  
Colon Tumorigenesis ◽  
Mouse Colon ◽  
Dipeptidyl Peptidase 4 Inhibitor ◽  
Type 2 Diabetic

M1737 R-Etodolac Induces E-Cadherin and Suppresses Colitis-Related Mouse Colon Carcinogenesis

2010 ◽  
Vol 138 (5) ◽  
pp. S-409
Author(s):  
Takuya Inoue ◽  
Mitsuyuki Murano ◽  
Takanori Kuramoto ◽  
Kazuki Kakimoto ◽  
Kumi Ishida ◽  
...  
Keyword(s):  
Colon Carcinogenesis ◽  
Mouse Colon ◽  
E Cadherin

scholarly journals E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease

2019 ◽  
Vol 20 (11) ◽  
pp. 2756 ◽  
Author(s):  
Amanda C. Daulagala ◽  
Mary Catherine Bridges ◽  
Antonis Kourtidis
Keyword(s):  
Cell Behavior ◽  
Colonic Epithelium ◽  
Core Component ◽  
Critical Function ◽  
The Core ◽  
Colon Tumorigenesis ◽  
Barrier Formation ◽  
Traditional Roles ◽  
E Cadherin

E-cadherin is the core component of epithelial adherens junctions, essential for tissue development, differentiation, and maintenance. It is also fundamental for tissue barrier formation, a critical function of epithelial tissues. The colon or large intestine is lined by an epithelial monolayer that encompasses an E-cadherin-dependent barrier, critical for the homeostasis of the organ. Compromised barriers of the colonic epithelium lead to inflammation, fibrosis, and are commonly observed in colorectal cancer. In addition to its architectural role, E-cadherin is also considered a tumor suppressor in the colon, primarily a result of its opposing function to Wnt signaling, the predominant driver of colon tumorigenesis. Beyond these well-established traditional roles, several studies have portrayed an evolving role of E-cadherin as a signaling epicenter that regulates cell behavior in response to intra- and extra-cellular cues. Intriguingly, these recent findings also reveal tumor-promoting functions of E-cadherin in colon tumorigenesis and new interacting partners, opening future avenues of investigation. In this Review, we focus on these emerging aspects of E-cadherin signaling, and we discuss their implications in colon biology and disease.

scholarly journals Trp53 null and R270H mutant alleles have comparable effects in regulating invasion, metastasis, and gene expression in mouse colon tumorigenesis

2019 ◽  
Vol 99 (10) ◽  
pp. 1454-1469 ◽  
Author(s):  
Jinyu Tang ◽  
Ying Feng ◽  
Rork Kuick ◽  
Megan Green ◽  
Maranne Green ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Tumorigenesis ◽  
Mouse Colon
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