scholarly journals Evaluation of the novel gene Rabl3 in the regulation of proliferation and motility in human cancer cells

2010 ◽  
Vol 24 (2) ◽  
Author(s):  
Wang
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
The Novel ◽  
Human Cancer Cells ◽  
Novel Gene ◽  
Regulation Of Proliferation

The novel targets for anti-angiogenesis of genistein on human cancer cells

2005 ◽  
Vol 69 (2) ◽  
pp. 307-318 ◽  
Author(s):  
Shu-Jem Su ◽  
Trai-Ming Yeh ◽  
Woei-Jer Chuang ◽  
Chung-Liang Ho ◽  
Kee-Lung Chang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
The Novel ◽  
Human Cancer Cells ◽  
Novel Targets

The novel HDAC inhibitor NDACI054 sensitizes human cancer cells to radiotherapy

2013 ◽  
Vol 109 (1) ◽  
pp. 126-132 ◽  
Author(s):  
Stephanie Hehlgans ◽  
Katja Storch ◽  
Inga Lange ◽  
Nils Cordes
Keyword(s):  
Cancer Cells ◽  
Hdac Inhibitor ◽  
Human Cancer ◽  
The Novel ◽  
Human Cancer Cells

The novel anthraquinone derivative IMP1338 induces death of human cancer cells by p53-independent S and G2/M cell cycle arrest

2016 ◽  
Vol 79 ◽  
pp. 308-314 ◽  
Author(s):  
Hyun Kyung Choi ◽  
Hwani Ryu ◽  
A-rang Son ◽  
Bitna Seo ◽  
Sang-Gu Hwang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Human Cancer ◽  
The Novel ◽  
M Cell ◽  
Anthraquinone Derivative ◽  
Human Cancer Cells ◽  
Cycle Arrest

Abstract 3534: Development of the novel AAV-based vectors with selective tropism to human cancer cells

2015 ◽  
Author(s):  
Rana Sayroo ◽  
Zifei Yin ◽  
Diego Nolasco ◽  
Munjal Pandya ◽  
Chen Ling ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
The Novel ◽  
Human Cancer Cells

Genotoxic effects of irinotecan combined with the novel platinum(II) complexes in human cancer cells

2010 ◽  
Vol 188 (1) ◽  
pp. 66-74 ◽  
Author(s):  
Renata Kontek ◽  
Ksenia Matlawska-Wasowska ◽  
Urszula Kalinowska-Lis ◽  
Beata Marciniak
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
The Novel ◽  
Genotoxic Effects ◽  
Human Cancer Cells

scholarly journals Novel FOXM1 inhibitor identified via gene network analysis induces autophagic FOXM1 degradation to overcome chemoresistance of human cancer cells

2021 ◽  
Vol 12 (7) ◽  
Author(s):  
Mikhail S. Chesnokov ◽  
Marianna Halasi ◽  
Soheila Borhani ◽  
Zarema Arbieva ◽  
Binal N. Shah ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
The Novel ◽  
Cytotoxic Effects ◽  
Regulatory Pathways ◽  
Human Cancer Cells ◽  
Subsequent Degradation ◽  
Foxm1 Protein ◽  
Gene Network Analysis ◽  
Increased Sensitivity

AbstractFOXM1 transcription factor is an oncogene and a master regulator of chemoresistance in multiple cancers. Pharmacological inhibition of FOXM1 is a promising approach but has proven to be challenging. We performed a network-centric transcriptomic analysis to identify a novel compound STL427944 that selectively suppresses FOXM1 by inducing the relocalization of nuclear FOXM1 protein to the cytoplasm and promoting its subsequent degradation by autophagosomes. Human cancer cells treated with STL427944 exhibit increased sensitivity to cytotoxic effects of conventional chemotherapeutic treatments (platinum-based agents, 5-fluorouracil, and taxanes). RNA-seq analysis of STL427944-induced gene expression changes revealed prominent suppression of gene signatures characteristic for FOXM1 and its downstream targets but no significant changes in other important regulatory pathways, thereby suggesting high selectivity of STL427944 toward the FOXM1 pathway. Collectively, the novel autophagy-dependent mode of FOXM1 suppression by STL427944 validates a unique pathway to overcome tumor chemoresistance and improve the efficacy of treatment with conventional cancer drugs.

Indirubin derivatives inhibit SFKs/Stat signaling associated with apoptosis in human cancer cells

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
S Nam ◽  
R Buettner ◽  
X Liu ◽  
J Turkson ◽  
D Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Stat Signaling
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