scholarly journals Comprehensive analysis of excision repair complementation group 1, glutathione S-transferase, thymidylate synthase and uridine diphosphate glucuronosyl transferase 1A1 polymorphisms predictive for treatment outcome in patients with advanced gastric cancer treated with FOLFOX or FOLFIRI

2009 ◽  
Vol 22 (01) ◽  
Author(s):  
Kim
Keyword(s):  
Gastric Cancer ◽  
Treatment Outcome ◽  
Thymidylate Synthase ◽  
Excision Repair ◽  
Complementation Group ◽  
Comprehensive Analysis ◽  
Uridine Diphosphate ◽  
Glutathione S Transferase ◽  
Glucuronosyl Transferase ◽  
Group 1

scholarly journals Prognostic value of excision repair cross-complementation group 1 expression in gastric cancer: A meta-analysis

2015 ◽  
Vol 9 (4) ◽  
pp. 1393-1400 ◽  
Author(s):  
PENG SONG ◽  
QIN YIN ◽  
MING LU ◽  
BO FU ◽  
BAOLIN WANG ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Value ◽  
Excision Repair ◽  
Meta Analysis ◽  
Complementation Group ◽  
Group 1

Excision Repair Cross Complementation Group 1 and Thymidylate Synthase Expression in Patients With Mesothelioma

2013 ◽  
Vol 14 (2) ◽  
pp. 164-171 ◽  
Author(s):  
Steven C.H. Kao ◽  
Kenneth Lee ◽  
Sonja Klebe ◽  
Douglas Henderson ◽  
Brian McCaughan ◽  
...  
Keyword(s):  
Thymidylate Synthase ◽  
Excision Repair ◽  
Complementation Group ◽  
Group 1

Thymidylate Synthase But Not Excision Repair Cross-Complementation Group 1 Tumor Expression Predicts Outcome in Patients With Malignant Pleural Mesothelioma Treated With Pemetrexed-Based Chemotherapy

2010 ◽  
Vol 28 (9) ◽  
pp. 1534-1539 ◽  
Author(s):  
Luisella Righi ◽  
Mauro G. Papotti ◽  
Paolo Ceppi ◽  
Andrea Billè ◽  
Elisa Bacillo ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Thymidylate Synthase ◽  
Excision Repair ◽  
Single Agent ◽  
Complementation Group ◽  
Pleural Mesothelioma ◽  
Mrna Levels ◽  
Lower Tertile ◽  
Protein Levels ◽  
Group 1

PurposeThe relationship between thymidylate synthase (TS) expression and outcome in patients with malignant pleural mesothelioma (MPM) treated with pemetrexed (P) was retrospectively evaluated.Patients and MethodsSixty histologically confirmed patients with MPM previously treated with P and platinum (45 of 60) or as single agent (15 of 60) were retrospectively considered. Eighty-one control patients with MPM not P-treated were also evaluated. TS and excision repair cross-complementation group 1 (ERCC1) gene expression levels were evaluated by real-time polymerase chain reaction and by immunohistochemistry using the H-score.ResultsMedian TS H-score value was 90 (range, 5 to 240). A significant correlation between low TS protein expression and longer time to progression (TTP; 17.9 v 7.9 months; hazard ratio [HR], 2.05, 95% CI, 1.19 to 3.77; P = .02) or overall survival (OS; 30 v 16.7 months; HR, 2.38; 95% CI, 1.15 to 4.91; P = .019) was found when patients were divided according to median H-score. Conversely, TS mRNA levels were not significantly correlated with outcome. In platinum-treated patients (n = 45), no correlation was found with survival according to ERCC1 median H-score, but patients in the lower tertile had a significantly shorter survival (HR, 3.06; 95% CI, 1.08 to 8.69; P = .035). In control MPMs, TS had no prognostic role. At multivariate analysis, TS protein levels were the only independent prognostic factor for both TTP (HR, 2.71; 95% CI, 1.13 to 6.49; P = .02) and OS (HR, 6.91; 95% CI, 1.90 to 25.07; P = .003).ConclusionIn patients with MPM treated with P-based chemotherapy, low TS protein levels are predictive of improved TTP and OS. The role of TS assessment is worth of prospective validation in future studies on MPM.

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