scholarly journals Inhibition of proliferation and apoptosis induced by a Na+/H+ exchanger-1 (NHE-1) antisense gene on drug-resistant human small cell lung cancer cells

2009 ◽  
Vol 21 (5) ◽  
Author(s):  
Wu
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Drug Resistant ◽  
Small Cell Lung ◽  
Antisense Gene ◽  
Inhibition Of Proliferation ◽  
Proliferation And Apoptosis

scholarly journals Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells

2020 ◽  
Vol 20 (2) ◽  
pp. 1256-1262
Author(s):  
Yan Huang ◽  
Ting Bao ◽  
Zhenzhen Li ◽  
Guiyi Ji ◽  
Li Zhang
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung ◽  
Proliferation And Apoptosis

scholarly journals Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells

Oncogene ◽  
2012 ◽  
Vol 32 (2) ◽  
pp. 209-221 ◽  
Author(s):  
M-J Jung ◽  
J-K Rho ◽  
Y-M Kim ◽  
J E Jung ◽  
Y B Jin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Drug Resistant ◽  
Small Cell Lung

scholarly journals Significance of c‐ MET overexpression in cytotoxic anticancer drug‐resistant small‐cell lung cancer cells

2014 ◽  
Vol 105 (8) ◽  
pp. 1032-1039 ◽  
Author(s):  
Hiroaki Ozasa ◽  
Tetsuya Oguri ◽  
Ken Maeno ◽  
Osamu Takakuwa ◽  
Eiji Kunii ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Drug Resistant ◽  
Small Cell Lung

scholarly journals α-Lipoic acid-induced inhibition of proliferation and met phosphorylation in human non-small cell lung cancer cells

2013 ◽  
Vol 335 (2) ◽  
pp. 472-478 ◽  
Author(s):  
Hiromitsu Michikoshi ◽  
Takahiro Nakamura ◽  
Katsuya Sakai ◽  
Yoshinori Suzuki ◽  
Eri Adachi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Lipoic Acid ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung ◽  
Inhibition Of Proliferation ◽  
Met Phosphorylation

scholarly journals Overexpression of Osimertinib-resistant ABCG2 in Non-small cell lung cancer cells

2021 ◽  
Author(s):  
Mei Wang ◽  
Junyao Jiang ◽  
Yuxuan Du ◽  
Shuaimei Liu ◽  
Xiaojun Ge
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
High Performance ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Drug Resistant ◽  
Small Cell Lung ◽  
Resistant Cells

Abstract Objective: Osimertinib is one of the commonly used chemotherapeutic drugs for treatment of non-small cell lung cancer (NSCLC). Nonetheless, the eventual resistance developed by cancer cells to Osimertinib has led to limitations in its application. Accordingly, there is a significant need for identifying means of reversing Osimertinib resistance.Method: The CCK-8 method was employed in detecting cell proliferation and toxicity. Western blot analysis detected protein expression, cell invasion analysis was performed using transwell assays, and the concentration of Osimertinib was determined using high performance liquid chromatography (HPLC). Result: In this study, we constructed Osimertinib-resistant cells, thus indicating the vital role of ABCG2 expression in formation of drug-resistant cells. Down-regulating ABCG2 expression in drug-resistant cells can reduce the lung cancer cells’ IC50, degree of proliferation and invasion. Combining use of ERK and PI3K inhibitors to inhibit ABCG2 expression is superior to employing a single inhibitor. Conclusion: Inhibiting the expression of ABCG2 can reverse the resistance of NSCLC cells to Osimertinib. Overexpression of ABCG2 is caused by the coactivation of the MAPK and the PI3K/AKT pathways.

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