Lung cancer patients with chronic obstructive pulmonary disease.

2001 ◽  
Author(s):  
K Kurishima ◽  
H Satoh ◽  
H Ishikawa ◽  
Y T Yamashita ◽  
T Homma ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Chronic Obstructive Pulmonary Disease ◽  
Cancer Patients ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Lung Cancer Patients

scholarly journals Chronic Obstructive Pulmonary Disease in Lung Cancer Patients: Prevalence, Underdiagnosis, and Clinical Characterization

Respiration ◽  
2018 ◽  
Vol 95 (6) ◽  
pp. 414-421 ◽  
Author(s):  
Cecilia Mouronte-Roibás ◽  
Virginia Leiro-Fernández ◽  
Alberto Ruano-Raviña ◽  
Cristina Ramos-Hernández ◽  
José Abal-Arca ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Chronic Obstructive Pulmonary Disease ◽  
Cancer Patients ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Lung Cancer Patients

scholarly journals CircRNA0001859, a new diagnostic and prognostic biomarkers for COPD and AECOPD

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Shuifang Chen ◽  
Yinan Yao ◽  
Shan Lu ◽  
Junjun Chen ◽  
Guangdie Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Chronic Obstructive Pulmonary Disease ◽  
Cancer Patients ◽  
Pulmonary Disease ◽  
Characteristic Curve ◽  
Healthy Person ◽  
Chronic Obstructive ◽  
Mice Model ◽  
Obstructive Pulmonary Disease ◽  
Lung Cancer Patients

Abstract Background Dysregulation of circRNAs has been reported to be functionally associated with chronic obstructive pulmonary disease (COPD). The present investigation elucidated the potential role of CircRNA0001859 in regulating chronic obstructive pulmonary disease acute (COPD) and Acute Exacerbation of COPD (AECOPD). Methods Mice model of COPD was established to screen and verify the dysregulated expression of CircRNA0001859. Fluorescence in situ hybridization (FISH) and quantitative real-time PCR (qRT-PCR) were carried out to detect the expression of CircRNA0001859. 38 stable COPD patients, 24 AECOPD patients, 57 COPD with lung cancer patients and 28 healthy person with age and sex matched to total patients were used for the present investigation. Results circRNA0001859 was downregulated in the lung tissue of mice after the three kinds of treatments (Cigarette smoke (CS)/NK alone or CS + NNK) for inducing COPD. FISH assay verified the downregulation of circRNA0001859 both in the mice lung and human bronchial epithelial cell of COPD model. Furthermore,, the level of circRNA0001859 was also downregulated in the peripheral blood of COPD and lung cancer patients. CircRNA0001859 might act as a diagnostic and prognostic biomarker for the treatment of in COPD and AECOPD with Are under the receiver operating characteristic curve (ROC curve) (AUC) of 0.7433 and 0.8717, respectively. Conclusion We explored a novel circRNA0001859, which might act as a potential therapeutic biomarker for the treatment of COPD and AECOPD.

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