Follicular thyroid cancer cells: a model of metastatic tumor in vitro (review).

2001 ◽  
Author(s):  
T Hoelting ◽  
P E Goretzki ◽  
Q Y Duh
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Metastatic Tumor ◽  
Follicular Thyroid Cancer ◽  
Thyroid Cancer Cells

scholarly journals Combinatorial Antitumor Effect of Rapamycin andβ-Elemene in Follicular Thyroid Cancer Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Jun Zhou ◽  
Li-Li He ◽  
Xiao-Fei Ding ◽  
Qiu-Qi Yuan ◽  
Jian-Xin Zhang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Antitumor Effect ◽  
Mtor Inhibitor ◽  
Objective Response ◽  
Underlying Mechanism ◽  
Follicular Thyroid Cancer ◽  
Thyroid Cancer Cells

Background.mTOR signaling would be a promising target for thyroid cancer therapy. However, in clinical trials, objective response rate with mTOR inhibitor monotherapy in most cancer types was modest. A new focus on development of combinatorial strategies with rapalogs is increasing.Objective.Investigating the combinatorial antitumor effect of rapamycin andβ-elemene in follicular thyroid cancer cells.Methods.MTT assay was used to determine the FTC-133 cell proliferation after culturing with rapamycin and/orβ-elemene. To analyze their combinatorial effect, immunoblotting was performed to analyze the activation status of AKT. Moreover,β-elemene attenuated rapamycin-induced immunosuppression was tested in mice.Results.Combination of rapamycin andβ-elemene exerted significant synergistic antiproliferative effects in FTC-133 cell linesin vitro, based on inhibiting the AKT feedback activation induced by rapamycin.In vivo, theβ-elemene could attenuate rapamycin-induced immunosuppression via reversing imbalance of Treg/Th17, with the underlying mechanism needed to be declared.Conclusions. We demonstrate that the novel combination of mTOR inhibitor withβ-elemene synergistically attenuates tumor cell growth in follicular thyroid cancer, which requires additional preclinical validation.

Functional Thyrotropin Receptor Attenuates Malignant Phenotype of Follicular Thyroid Cancer Cells

Endocrine ◽  
2006 ◽  
Vol 30 (1) ◽  
pp. 129-138 ◽  
Author(s):  
S. Hoffmann ◽  
K. Maschuw ◽  
I. Hassan ◽  
A. Wunderlich ◽  
S. Lingelbach ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Thyrotropin Receptor ◽  
Follicular Thyroid Cancer ◽  
Malignant Phenotype ◽  
Thyroid Cancer Cells

Dual inhibition of BRAF and MEK increases expression of sodium iodide symporter in patient-derived papillary thyroid cancer cells in vitro

Surgery ◽  
2020 ◽  
Vol 167 (1) ◽  
pp. 56-63 ◽  
Author(s):  
Timothy M. Ullmann ◽  
Heng Liang ◽  
Maureen D. Moore ◽  
Isra Al-Jamed ◽  
Katherine D. Gray ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Papillary Thyroid Cancer ◽  
Sodium Iodide ◽  
Papillary Thyroid ◽  
Sodium Iodide Symporter ◽  
Dual Inhibition ◽  
Thyroid Cancer Cells

scholarly journals Effects of sorafenib and an adenylyl cyclase activator on in vitro growth of well-differentiated thyroid cancer cells

2017 ◽  
Vol 64 (11) ◽  
pp. 1115-1123 ◽  
Author(s):  
Aya Sawa ◽  
Tomohiro Chiba ◽  
Jun Ishii ◽  
Hiroyuki Yamamoto ◽  
Hisato Hara ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Adenylyl Cyclase ◽  
Cancer Cells ◽  
Differentiated Thyroid Cancer ◽  
Well Differentiated ◽  
Thyroid Cancer Cells ◽  
Cyclase Activator

High doses of hydroxytyrosol induce apoptosis in papillary and follicular thyroid cancer cells

2016 ◽  
Vol 40 (2) ◽  
pp. 153-162 ◽  
Author(s):  
G. Toteda ◽  
S. Lupinacci ◽  
D. Vizza ◽  
R. Bonofiglio ◽  
E. Perri ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Follicular Thyroid Cancer ◽  
High Doses ◽  
Thyroid Cancer Cells
Sign in / Sign up

Export Citation Format

Share Document