Tissue-specific expression of the p53 tumor-suppressor gene in the intestine of transgenic mice exposed to DMH and p53 antibodies.

1999 ◽  
Author(s):  
Y Tendler ◽  
P Guervich ◽  
B Sandler ◽  
E Diamond ◽  
S Lischinsky ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Transgenic Mice ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Specific Expression ◽  
Tissue Specific ◽  
P53 Tumor Suppressor ◽  
Tissue Specific Expression ◽  
P53 Tumor Suppressor Gene ◽  
P53 Antibodies

scholarly journals Biological and clinical importance of the p53 tumor suppressor gene

1996 ◽  
Vol 42 (6) ◽  
pp. 858-868 ◽  
Author(s):  
V E Velculescu ◽  
W S El-Deiry
Keyword(s):  
Dna Damage ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
P53 Gene ◽  
Suppressor Gene ◽  
Chemotherapeutic Agents ◽  
Cellular Growth ◽  
P53 Tumor Suppressor ◽  
P53 Tumor Suppressor Gene ◽  
P53 Antibodies

Abstract The p53 tumor suppressor gene controls cellular growth after DNA damage through mechanisms involving growth arrest and apoptosis. Mutations that inactivate p53 occur commonly in virtually all human malignancies and can be detected by sequencing of the p53 gene, immunohistochemical staining of tumor tissue with anti-p53 antibodies, single-strand conformation polymorphisms, or other biological assays. Identification of p53 mutation in the germ line is diagnostic of the cancer-prone Li-Fraumeni syndrome. Alterations of the p53 gene result in defective cellular responses after DNA damage and predispose cells to dysregulated growth, tumor formation and progression, and potential resistance (of tumor cells) to certain chemotherapeutic agents or ionizing radiation. A variety of tumors involving mutant p53 have a worse prognosis than tumors of the same type containing no p53 mutations. New diagnostic and therapeutic strategies are evolving as the p53 pathways of cell-cycle arrest and apoptosis become elucidated.

Mutation of the p53 tumor-suppressor gene is not a feature of endometrial hyperplasias

1993 ◽  
Vol 169 (3) ◽  
pp. 690-694 ◽  
Author(s):  
Matthew F. Kohler ◽  
Hiroshi Nishii ◽  
Peter A. Humphrey ◽  
Hiroshi Saski ◽  
Jeffrey Marks ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
P53 Tumor Suppressor ◽  
P53 Tumor Suppressor Gene

P53 tumor suppressor gene mutations in hepatocellular carcinoma patients in India

Cancer ◽  
2000 ◽  
Vol 88 (7) ◽  
pp. 1565-1573 ◽  
Author(s):  
Sanjay Katiyar ◽  
Bipin C. Dash ◽  
Varsha Thakur ◽  
Raj C. Guptan ◽  
Shiv K. Sarin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Gene Mutations ◽  
Suppressor Gene ◽  
P53 Tumor Suppressor ◽  
P53 Tumor Suppressor Gene
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