Plant tannins as inhibitors of hydroperoxide production and tumor promotion induced by ultraviolet B radiation in mouse skin in vivo.

1999 ◽  
Author(s):  
H U Gali-Muhtasib ◽  
S Z Yamout ◽  
M M Sidani
Keyword(s):  
Mouse Skin ◽  
Tumor Promotion ◽  
Ultraviolet B ◽  
Ultraviolet B Radiation

Autologous nitric oxide protects mouse and human keratinocytes from ultraviolet B radiation-induced apoptosis

2003 ◽  
Vol 284 (5) ◽  
pp. C1140-C1148 ◽  
Author(s):  
Richard Weller ◽  
Ann Schwentker ◽  
Timothy R. Billiar ◽  
Yoram Vodovotz
Keyword(s):  
Nitric Oxide ◽  
Soluble Guanylate Cyclase ◽  
Ultraviolet B ◽  
Skin Damage ◽  
Wild Type ◽  
No Donor ◽  
Ultraviolet B Radiation ◽  
Inducible Nos

Nitric oxide (NO) can either prevent or promote apoptosis, depending on cell type. In the present study, we tested the hypothesis that NO suppresses ultraviolet B radiation (UVB)-induced keratinocyte apoptosis both in vitro and in vivo. Irradiation with UVB or addition of the NO synthase (NOS) inhibitor N G-nitro-l-arginine methyl ester (l-NAME) increased apoptosis in the human keratinocyte cell line CCD 1106 KERTr, and apoptosis was greater when the two agents were given in combination. Addition of the chemical NO donor S-nitroso- N-acetyl-penicillamine (SNAP) immediately after UVB completely abrogated the rise in apoptosis induced by l-NAME. An adenoviral vector expressing human inducible NOS (AdiNOS) also reduced keratinocyte death after UVB. Caspase-3 activity, an indicator of apoptosis, doubled in keratinocytes incubated with l-NAME compared with the inactive isomer, d-NAME, and was reduced by SNAP. Apoptosis was also increased on addition of 1,H-[1,2,4]oxadiazolo[4,3- a]quinoxalin-1-one (ODQ), an inhibitor of soluble guanylate cyclase. Mice null for endothelial NOS (eNOS) exhibited significantly higher apoptosis than wild-type mice both in the dermis and epidermis, whereas mice null for inducible NOS (iNOS) exhibited more apoptosis than wild-type mice only in the dermis. These results demonstrate an antiapoptotic role for NO in keratinocytes, mediated by cGMP, and indicate an antiapoptotic role for both eNOS and iNOS in skin damage induced by UVB.

Phloroglucinol inhibits ultraviolet B radiation-induced oxidative stress in the mouse skin

2014 ◽  
Vol 90 (10) ◽  
pp. 928-935 ◽  
Author(s):  
Mei Jing Piao ◽  
Mee Jung Ahn ◽  
Kyoung Ah Kang ◽  
Ki Cheon Kim ◽  
Jian Zheng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Skin ◽  
Ultraviolet B ◽  
Ultraviolet B Radiation ◽  
Radiation Induced

Ultraviolet-B Radiation Causes an Upregulation of Survivin in Human Keratinocytes and Mouse Skin¶

2004 ◽  
Vol 80 (3) ◽  
pp. 602 ◽  
Author(s):  
Moammir Hasan Aziz ◽  
Amaninderapal S. Ghotra ◽  
Yogeshwer Shukla ◽  
Nihal Ahmad
Keyword(s):  
Mouse Skin ◽  
Human Keratinocytes ◽  
Ultraviolet B ◽  
Ultraviolet B Radiation

Abstract 4644: Curcumin C3 ® prevents ultraviolet B radiation-induced acute damage in JB6 keratinocytes and mouse skin via FGF-2/mTOR/NF-KB pathway

2015 ◽  
Author(s):  
Alok R. Khandelwal ◽  
Arun Anandharaj ◽  
Ekshyyan Oleksandr ◽  
Tara Moore-Medlin ◽  
Abreo Fleurette ◽  
...  
Keyword(s):  
Mouse Skin ◽  
Ultraviolet B ◽  
Ultraviolet B Radiation ◽  
Radiation Induced

Ultraviolet-B Radiation Causes an Upregulation of Survivin in Human Keratinocytes and Mouse Skin¶

2007 ◽  
Vol 80 (3) ◽  
pp. 602-608 ◽  
Author(s):  
Moammir Hasan Aziz ◽  
Amaninderapal S. Ghotra ◽  
Yogeshwer Shukla ◽  
Nihal Ahmad
Keyword(s):  
Mouse Skin ◽  
Human Keratinocytes ◽  
Ultraviolet B ◽  
Ultraviolet B Radiation
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