Aphidicolin glycinate inhibits human neuroblastoma cell growth in vivo.

1999 ◽  
Author(s):  
J Cinatl ◽  
R Kotchetkov ◽  
P H Driever ◽  
S Bertels ◽  
K Siems ◽  
...  
Keyword(s):  
Cell Growth ◽  
Neuroblastoma Cell ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma

scholarly journals Effects of serum and insulin-like growth factors on human neuroblastoma cell growth

1993 ◽  
Vol 48 (1-2) ◽  
pp. 217-224 ◽  
Author(s):  
Mihir A. Meghani ◽  
Donna M. Martin ◽  
J.Robinson Singleton ◽  
Eva L. Feldman
Keyword(s):  
Growth Factors ◽  
Cell Growth ◽  
Neuroblastoma Cell ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Insulin Like Growth Factors

scholarly journals Inhibition of the SK-N-MC human neuroblastoma cell line in vivo and in vitro by a novel nutrient mixture

2013 ◽  
Vol 29 (5) ◽  
pp. 1714-1720 ◽  
Author(s):  
M. WAHEED ROOMI ◽  
TATIANA KALINOVSKY ◽  
NUSRATH W. ROOMI ◽  
ALEKSANDRA NIEDZWIECKI ◽  
MATTHIAS RATH
Keyword(s):  
Cell Line ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cell Line ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Human Neuroblastoma Cell Line

Characterization of SH-SY5Y human neuroblastoma cell growth over glass and SU-8 substrates

2017 ◽  
Vol 105 (8) ◽  
pp. 2129-2138 ◽  
Author(s):  
A. Ajetunmobi ◽  
D. McAllister ◽  
N. Jain ◽  
O. Brazil ◽  
A. Corvin ◽  
...  
Keyword(s):  
Cell Growth ◽  
Neuroblastoma Cell ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma

Synthesis of new phosphate derivative of benzothiazole and its inhibiting effect on two series of human neuroblastoma cell growth

2013 ◽  
Vol 30 (3) ◽  
pp. 675-679
Author(s):  
Mahshid Nikpour Nezhati ◽  
Gholam Hossein Riazi ◽  
Homayon Ahmad Panahi ◽  
Elham Moniri ◽  
Nasir Ahmad Rajabi ◽  
...  
Keyword(s):  
Cell Growth ◽  
Neuroblastoma Cell ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Inhibiting Effect

scholarly journals PI3K activation prevents Aβ42-induced synapse loss and favors insoluble amyloid deposits formation

2019 ◽  
Author(s):  
Mercedes Arnés ◽  
Ninovska Romero ◽  
Sergio Casas-Tintó ◽  
Ángel Acebes ◽  
Alberto Ferrús
Keyword(s):  
Neuroblastoma Cell ◽  
Human Neuroblastoma Cell ◽  
Neuroprotective Effects ◽  
Human Neuroblastoma ◽  
Synapse Loss ◽  
Amyloid Deposits ◽  
Pi3k Activation ◽  
Aβ42 Peptide

AbstractAlzheimer’s disease is, to a large extent, a disease of the synapse triggered by the unbalanced amyloidogenic cleavage of the amyloid precursor protein APP. Excess of Aβ42 peptide in particular is considered a hallmark of the disease. Here we drive the expression of the human Aβ42 peptide to assay the neuroprotective effects of PI3K in adult Drosophila melanogaster. We show that the neuronal expression of the human peptide elicits progressive toxicity in the adult. The pathological traits include reduced axonal transport, synapse loss, defective climbing ability and olfactory perception, as well as life-span reduction. The Aβ42-dependent synapse decay does not involve transcriptional changes in the core synaptic protein encoding genes: bruchpilot, liprin and synaptobrevin. All toxicity features, however, are suppressed by the co-expression of PI3K. Moreover, PI3K activation induces a significant increase of 6E10 and Thioflavin-positive amyloid deposits. Mechanistically, we suggest that Aβ42-Ser26 could be a candidate residue for direct or indirect phosphorylation by PI3K. Finally, along with these in vivo experiments we further analyze Aβ42 toxicity and its suppression by PI3K activation in in vitro assays with SH-SY5Y human neuroblastoma cell cultures, where Aβ42 aggregation into large insoluble deposits is reproduced. Taken together, these results uncover a potential novel pharmacological strategy against this disease with PI3K activation as a target.

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