High prognostic impact of growth fraction parameters in advanced stage laryngeal squamous cell carcinoma.

1999 ◽  
Author(s):  
G Valente ◽  
U Giusti ◽  
S Kerim ◽  
P Gabriele ◽  
M Motta ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Growth Fraction ◽  
Prognostic Impact ◽  
Advanced Stage

EGFR cut-off point for prognostic impact in laryngeal squamous cell carcinoma

2020 ◽  
Vol 140 (7) ◽  
pp. 603-607
Author(s):  
Thiratest Leesutipornchai ◽  
Thanaporn Ratchataswan ◽  
Sarocha Vivatvakin ◽  
Komkrit Ruangritchankul ◽  
Somboon Keelawat ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Prognostic Impact

Comparison of the Adult Comorbidity Evaluation 27 and the Charlson Comorbidity indices in patients with laryngeal squamous cell carcinoma

2012 ◽  
Vol 126 (5) ◽  
pp. 516-524 ◽  
Author(s):  
V S Nesic ◽  
Z M Petrovic ◽  
S B Sipetic ◽  
S D Jesic ◽  
I A Soldatovic ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Charlson Comorbidity Index ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Prognostic Impact ◽  
Disease Specific Survival ◽  
Comorbidity Index ◽  
The Impact ◽  
Disease Specific

AbstractObjective:This study aimed to compare the prognostic impact of comorbidity grading by the Adult Comorbidity Evaluation 27 index and the Charlson Comorbidity Index on the five-year overall and disease-specific survival in patients undergoing surgery for laryngeal squamous cell carcinoma.Methods:The impact of comorbidity and other factors on survival was examined retrospectively in a group of 177 patients with previously untreated tumour stage one to four laryngeal squamous cell carcinoma surgically treated at the Clinic of Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, between 2000 and 2003. The Cox proportional hazard model was used to identify independent prognostic factors.Results:On univariate analysis, comorbidity had an impact on prognosis regardless of which index was used. On multivariate analysis, the significant predictors of patients' five-year overall and disease-specific survival were tumour–node–metastasis stage and comorbidity as graded by the Adult Comorbidity Evaluation 27 index.Conclusion:The Adult Comorbidity Evaluation 27 index is a more reliable predictor of survival than the Charlson Comorbidity Index in patients with laryngeal squamous cell carcinoma.

scholarly journals Hypoxia-Inducible Factor-1α Expression in Indonesian Laryngeal Squamous Cell Carcinoma Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Agus Surono ◽  
Priyanto Priyanto ◽  
Sagung Rai Indrasari
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Early Stage ◽  
Clinical Stage ◽  
Hypoxia Inducible Factor ◽  
Advanced Stage ◽  
Chi Square ◽  
Chi Square Test

Objectives. This research aimed to determine the association between hypoxia-inducible factor-1α (HIF-1α) expression and laryngeal squamous cell carcinoma clinical stage. Methods. We retrospectively analyzed paraffin-embedded tissue from 47 laryngeal squamous cell carcinoma (LSCC) patients from 2011 to 2014. HIF-1α expression was analyzed by immunohistochemistry using an anti-HIF-1α mouse monoclonal antibody. The association between HIF-1α expression and clinical stage was analyzed using the chi square test. Results. The glottis was the predominant site of laryngeal squamous cell carcinoma occurrence, and 43/47 (91.5%) patients presented at an advanced stage. Of the advanced stage patients, 27/43 stained positive for HIF-1α expression and 16/43 stained negative. Of the early stage patients, 2/4 stained positive for HIF-1α expression and 2/4 stained negative. Statistical analysis did not demonstrate significant association of HIF-1α expression. Conclusion. There was no statistically significant association between HIF-1α expression and the clinical stage or histological differentiation of LSCC.

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