Treatment results and long-term follow-up in stage I seminoma patients.

1996 ◽  
Author(s):  
G Hofmockel ◽  
M Theiss ◽  
A Gruss
Keyword(s):  
Stage I ◽  
Treatment Results ◽  
Long Term Follow Up ◽  
Stage I Seminoma

Testicular seminoma stage I: Treatment results and long-term follow-up (1968–1988)

1993 ◽  
Vol 53 (3) ◽  
pp. 175-179 ◽  
Author(s):  
Moshe Efraim Stein ◽  
Ivan Kessel ◽  
Norman Luberant ◽  
Avraham Kuten
Keyword(s):  
Stage I ◽  
Treatment Results ◽  
Testicular Seminoma ◽  
Long Term Follow Up

Stage I and II Follicular Lymphoma With Gastrointestinal Involvement: Long-Term Follow-up of No Initial Therapy

2011 ◽  
Vol 140 (5) ◽  
pp. S-874
Author(s):  
Hiroyuki Okada ◽  
Katsuyoshi Takata ◽  
Yoshiro Kawahara ◽  
Masahumi Inoue ◽  
Seiji Kawano ◽  
...  
Keyword(s):  
Follicular Lymphoma ◽  
Initial Therapy ◽  
Stage I ◽  
Gastrointestinal Involvement ◽  
Long Term Follow Up

Adult primary extragonadal germ cell tumors: Treatment results and long-term follow-up

2003 ◽  
Vol 41 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Argon Andac ◽  
Basaran Mert ◽  
Bavbek Sevil ◽  
Sakar Burak ◽  
Onat Haluk
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Treatment Results ◽  
Long Term Follow Up ◽  
Extragonadal Germ Cell Tumors

2163 Subdiaphragmatic stage I & II Hodgkin's disease-long-term follow-up and prognostic factors

1997 ◽  
Vol 39 (2) ◽  
pp. 322
Author(s):  
Zhongxing Liao ◽  
Chul S. Ha ◽  
Lillian M. Fuller ◽  
Fredrick B. Hagemeister ◽  
Fernando Cabanillas ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Stage I ◽  
Long Term Follow Up

Treatment of stage I breast cancer (T1N0M0): A long-term follow-up study

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 11509-11509 ◽  
Author(s):  
J. Iturbe ◽  
J. P. Leone ◽  
A. O. Zwenger ◽  
J. A. Lacava ◽  
C. T. Vallejo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stage I ◽  
Follow Up Study ◽  
Long Term Follow Up

Long-term survival and competing causes of death in men with stage I seminoma.

2011 ◽  
Vol 29 (7_suppl) ◽  
pp. 226-226 ◽  
Author(s):  
C. Beard ◽  
M. Chen ◽  
N. D. Arvold ◽  
P. L. Nguyen ◽  
A. K. Ng ◽  
...  
Keyword(s):  
General Population ◽  
Testicular Cancer ◽  
Cancer Mortality ◽  
Stage I ◽  
Second Malignancy ◽  
Term Survival ◽  
All Cause Mortality ◽  
Stage I Seminoma

226 Background: To better understand the impact of RT on mortality, we analyzed long-term survival and patterns of excess mortality in men with stage I seminoma. Methods: 9,045 men with stage I seminoma were identified in the Surveillance Epidemiology and End Results database. Time to testicular-cancer mortality (TCM), death from second malignancy (SM), cardiovascular mortality (CVM) or suicide (SUIC) and all-cause mortality (ACM) were calculated. Survival estimates were calculated using the Kaplan-Meier method. Gender- and age-adjusted standardized mortality ratios (SMR) were calculated using U.S. population data. Cox and Fine and Gray multivariable analysis were used to evaluate the effect of RT on mortality outcomes. Results: 7,025 men (78%) received RT. After a median follow-up of 11.7 years, 869 men (9.6%) had died: sixty-five from TCM, 279 from SM, 169 from CVM and 37 from SUIC. 10-year rates of ACM and TCM were 4.24% and 0.52% among men who received RT and 7.14% and 1.22% among men who did not. Compared to the adjusted general population, men with seminoma had increased risk of ACM (SMR 1.12; 95% confidence interval [CI] 1.12-1.28), SM (SMR 1.78; 95% CI 1.58-2.00) and SUIC (SMR 1.40; 95% CI 1.02-1.94) and decreased risk of CVM (SMR 0.73; 95% CI 0.62-0.84). Rates of ACM, SM and SUIC (SMR, all p < 0.05) were increased whether RT was used or not. Men who received RT were less likely to die (adjusted hazard ratio [AHR] 0.76; 95% CI 0.65-0.89; p < 0.001) and had a lower risk of TCM (AHR 0.39; 95% CI 0.24-0.65; p < 0.001). There was no difference in CVM between men who did and did not receive RT (AHR 0.89; 95% CI 0.60-1.15; p = 0.230) and a numerical increase in SM in men who received RT as compared to others (AHR 1.25; 95% CI 0.90-1.72; p=0.180). Conclusions: Compared to the general population, men with a history of stage I seminoma had increased risks of all-cause mortality, death from second malignancies, and suicide. Our data suggest that 15 years after diagnosis, men who did receive RT may be more likely to die from a second malignancy than men who did not. Although not receiving RT was associated with higher testicular-cancer mortality, the results may reflect decreased access to care or follow-up as active surveillance protocols were not common during the study era. No significant financial relationships to disclose.

scholarly journals Analysis of changes in structural and hemodynamic parameters of the retina and foveolar avascular zone in patients with primary open-angle glaucoma and diabetes mellitus observed in long-term follow-up

2021 ◽  
Vol 20 (3) ◽  
pp. 59-77
Author(s):  
A. Zh. Fursova ◽  
Y. A. Gamza ◽  
O. G. Gusarevich ◽  
A. S. Derbeneva ◽  
M. V. Vasilyeva ◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Stage I ◽  
Hemodynamic Parameters ◽  
Open Angle ◽  
Avascular Zone ◽  
Long Term Follow Up ◽  
Group 3

PURPOSE. To study the changes in structural and hemodynamic parameters of the retina and foveolar avascular zone (FAZ) over time in patients with primary open-angle glaucoma (POAG) and diabetes mellitus (DM) observed in long-term follow-up.MATERIALS AND METHODS. The study included 258 patients (258 eyes) divided into five groups: group 1 — 58 patients (58 eyes) with stage I POAG and DM; group 2 — 50 patients (50 eyes) with stage I POAG; group 3 — 50 patients (50 eyes) with stage III POAG and DM; group 4 — 50 patients (50 eyes) with stage III POAG; group 5 — 50 patients (50 eyes) with DM. Patients underwent comprehensive ophthalmological examination, spectral domain optical coherence tomography (SD-OCT), optical coherence tomo-graphy angiography (OCT-A) of the macular region. The follow-up lasted 24 months.RESULTS. Analysis of the initial parameters in groups of patients with comorbidities showed the lowest values compared to controls, which were progressively worsening. MD in the group with DM + stage I POAG had reliably decreased after 12 months (by 5.05%), after 24 months by 12.12% (p≤0.05). The speed of GCL+IPL loss in groups 1 and 3 during the first year of observation was almost equal for initial and advanced glaucoma — 1.35 (-2.03%) and 1.32 (-2.36%) µm/year, but in group 3 the loss had doubled after two years (2.48 (-4.44%) and 1.41 (2.12%) µm/year). Deterioration of hymodynamic parameters in the macular region in groups 1 and 3 was noted primarily in the inner sectors (whole image vessel density in parafovea (PF wiVD) -0.79% during the first, and -2.57% during the second year in initial glaucoma, -0.6% and -1.24% in advanced, whole image vessel density in parafovea (PF wiVD) -0.2% and -1.22%, -0.66% and -1.56%, respectively). Parameters of FAZ had changed significantly after 2 years in patients with stage I POAG and DM: its area size had increased by 10.2%, perimeter by 4.49%, circularity index had decreased by 3.17%.CONCLUSION. Comorbidity of POAG and DM is accompanied by development and quick progression of significant changes in structural and hemodynamic parameters of the retina as observed by this long-term follow-up.

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