scholarly journals miRNA‑199b‑3p suppresses growth and progression of ovarian cancer via the CHK1/E‑cadherin/EMT signaling pathway by targeting ZEB1

2020 ◽  
Vol 45 (2) ◽  
pp. 569-581
Author(s):  
Liqun Wei ◽  
Yuanqi He ◽  
Shuhong Bi ◽  
Xiaoxiao Li ◽  
Jianzhong Zhang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Signaling Pathway ◽  
E Cadherin

scholarly journals Emodin Inhibits the Epithelial to Mesenchymal Transition of Epithelial Ovarian Cancer Cells via ILK/GSK-3β/Slug Signaling Pathway

2016 ◽  
Vol 2016 ◽  
pp. 1-16 ◽  
Author(s):  
Jingjing Lu ◽  
Ying Xu ◽  
Xuan Wei ◽  
Zhe Zhao ◽  
Jing Xue ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Signaling Pathway ◽  
Epithelial To Mesenchymal Transition ◽  
Epithelial Mesenchymal Transition ◽  
Underlying Mechanism ◽  
Ovarian Cancer Cells ◽  
Mesenchymal Transition ◽  
Invasion And Migration ◽  
E Cadherin

Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Despite the anticancer capabilities of emodin observed in many cancers, including EOC, the underlying molecular mechanism remains to be elucidated. A crucial link has been discovered between the acquisition of metastatic traits and the epithelial-mesenchymal transition (EMT). The present study aimed to determine whether emodin could inhibit the EMT of EOC cells and explore the underlying mechanism. The CCK-8 assay and transwell assay showed that emodin effectively repressed the abilities of proliferation, invasion, and migration in A2780 and SK-OV-3 cells. The Western blot showed that emodin upregulated epithelial markers (E-cadherin and Claudin) while it downregulated mesenchymal markers (N-cadherin and Vimentin) and transcription factor (Slug) in a dose-dependent fashion. After transfection of siRNA-Slug, both Slug and N-cadherin were downregulated in EOC cells while E-cadherin was upregulated, which was intensified by emodin. Besides, emodin decreased the expression of ILK, p-GSK-3β, β-catenin, and Slug. Transfection of siRNA-ILK also achieved the same effects, which was further strengthened by following emodin treatment. Nevertheless, SB216763, an inhibitor of GSK-3β, could reverse the effects of emodin except for ILK expression. These findings suggest that emodin inhibited the EMT of EOC cells via ILK/GSK-3β/Slug signaling pathway.

CNOT7 modulates biological functions of ovarian cancer cells via AKT signaling pathway

Life Sciences ◽  
2021 ◽  
Vol 268 ◽  
pp. 118996
Author(s):  
Jiangtao Yu ◽  
Xiaoli Hu ◽  
Xiuxiu Chen ◽  
Qiangyong Zhou ◽  
Qi Jiang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Ovarian Cancer Cells ◽  
Biological Functions ◽  
Akt Signaling Pathway

scholarly journals CEMIP promotes ovarian cancer development and progression via the PI3K/AKT signaling pathway

2019 ◽  
Vol 114 ◽  
pp. 108787 ◽  
Author(s):  
Fan Shen ◽  
Zhi-hong Zong ◽  
Yao Liu ◽  
Shuo Chen ◽  
Xiu-jie Sheng ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Cancer Development ◽  
Akt Signaling Pathway

scholarly journals E-Cadherin fragments as potential mediators for peritoneal metastasis in advanced epithelial ovarian cancer

2016 ◽  
Vol 114 (2) ◽  
pp. 213-220 ◽  
Author(s):  
Fabian Trillsch ◽  
Sascha Kuerti ◽  
Christine Eulenburg ◽  
Eike Burandt ◽  
Linn Woelber ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Peritoneal Metastasis ◽  
Advanced Epithelial Ovarian Cancer ◽  
E Cadherin

scholarly journals Twist2 contributes to cisplatin-resistance of ovarian cancer through the AKT/GSK-3β signaling pathway

2014 ◽  
Vol 7 (4) ◽  
pp. 1102-1108 ◽  
Author(s):  
TIAN WANG ◽  
YAN LI ◽  
ABIDAN TUERHANJIANG ◽  
WENWEN WANG ◽  
ZHANGYING WU ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Signaling Pathway ◽  
Cisplatin Resistance ◽  
Gsk 3Β

scholarly journals Reactive oxygen species promote ovarian cancer progression via the HIF-1α/LOX/E-cadherin pathway

2014 ◽  
Vol 32 (5) ◽  
pp. 2150-2158 ◽  
Author(s):  
YU WANG ◽  
JUN MA ◽  
HAORAN SHEN ◽  
CHENGJIE WANG ◽  
YUEPING SUN ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Ovarian Cancer ◽  
Cancer Progression ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
E Cadherin
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