scholarly journals MicroRNA‑138 modulates glioma cell growth, apoptosis and invasion through the suppression of the AKT/mTOR signalling pathway by targeting CREB1

2020 ◽  
Vol 44 (6) ◽  
pp. 2559-2568
Author(s):  
Chi Zhang ◽  
Qi Wang ◽  
Xiaowen Zhou ◽  
Lei Zhang ◽  
Ying Yao ◽  
...  
Keyword(s):  
Cell Growth ◽  
Glioma Cell ◽  
Signalling Pathway ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

scholarly journals Cucurbitacin E inhibits osteosarcoma cells proliferation and invasion through attenuation of PI3K/AKT/mTOR signalling pathway

2016 ◽  
Vol 36 (6) ◽  
Author(s):  
Ying Wang ◽  
Shumei Xu ◽  
Yaochi Wu ◽  
Junfeng Zhang
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Signalling Pathway ◽  
Cell Counting ◽  
Cell Cycle Distribution ◽  
Mesenchymal Transition ◽  
Cucurbitacin E ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

Cucurbitacin E (CuE), a potent member of triterpenoid family isolated from plants, has been confirmed as an antitumour agent by inhibiting proliferation, migration and metastasis in diverse cancer. However, the effects and mechanisms of CuE on osteosarcoma (OS) have not been well understood. The present study aimed to test whether CuE could inhibit growth and invasion of OS cells and reveal its underlying molecular mechanism. After various concentrations of CuE treatment, the anti-proliferative effect of CuE was assessed using the cell counting Kit-8 assay. Flow cytometry analysis was employed to measure apoptosis of OS cells. Cell cycle distribution was analysed by propidium iodide staining. Transwell assay was performed to evaluate the effect of CuE on invasion potential of OS cells. The protein levels were measured by western blot. In addition, the potency of CuE on OS cells growth inhibition was assessed in vivo. Our results showed that CuE inhibited cell growth and invasion, induced a cell cycle arrest and triggered apoptosis and modulated the expression of cell growth, cell cycle and cell apoptosis regulators. Moreover, CuE inhibited the PI3K/Akt/mTOR pathway and epithelial–mesenchymal transition (EMT), which suppressed the invasion and metastasis of OS. In addition, we also found that CuE inhibited OS cell growth in vivo. Taken together, our study demonstrated that CuE could inhibit OS tumour growth and invasion through inhibiting the PI3K/Akt/mTOR signalling pathway. Our findings suggest that CuE can be considered to be a promising anti-cancer agent for OS.

scholarly journals A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling

2007 ◽  
Vol 403 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Greg M. Findlay ◽  
Lijun Yan ◽  
Julia Procter ◽  
Virginie Mieulet ◽  
Richard F. Lamb
Keyword(s):  
Amino Acids ◽  
Growth Factor ◽  
Cell Growth ◽  
Mammalian Target Of Rapamycin ◽  
Signalling Pathway ◽  
Initiation Factor ◽  
S6 Kinase ◽  
Eukaryotic Initiation Factor 4E ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

The mTOR (mammalian target of rapamycin) signalling pathway is a key regulator of cell growth and is controlled by growth factors and nutrients such as amino acids. Although signalling pathways from growth factor receptors to mTOR have been elucidated, the pathways mediating signalling by nutrients are poorly characterized. Through a screen for protein kinases active in the mTOR signalling pathway in Drosophila we have identified a Ste20 family member (MAP4K3) that is required for maximal S6K (S6 kinase)/4E-BP1 [eIF4E (eukaryotic initiation factor 4E)-binding protein 1] phosphorylation and regulates cell growth. Importantly, MAP4K3 activity is regulated by amino acids, but not the growth factor insulin and is not regulated by the mTORC1 inhibitor rapamycin. Our results therefore suggest a model whereby nutrients signal to mTORC1 via activation of MAP4K3.

scholarly journals Identification of mutations in the PI3K-AKT-mTOR signalling pathway in patients with macrocephaly and developmental delay and/or autism

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Kit San Yeung ◽  
Winnie Wan Yee Tso ◽  
Janice Jing Kun Ip ◽  
Christopher Chun Yu Mak ◽  
Gordon Ka Chun Leung ◽  
...  
Keyword(s):  
Developmental Delay ◽  
Signalling Pathway ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

scholarly journals Hnf1α is required for proper gut epithelial endocrine cell specification and controls the mTOR signalling pathway in mice

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Francois Boudreau ◽  
Carine R Lussier ◽  
Francois Brial ◽  
Nathalie Rivard ◽  
Nathalie Perreault
Keyword(s):  
Endocrine Cell ◽  
Signalling Pathway ◽  
Cell Specification ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

scholarly journals Role of the mTOR Signalling Pathway in Human Sepsis-Induced Myocardial Dysfunction

2019 ◽  
Vol 35 (7) ◽  
pp. 875-883 ◽  
Author(s):  
Wei Cheng MM ◽  
Yun Long ◽  
Hao Wang ◽  
Wen Han MM ◽  
Jiahui Zhang ◽  
...  
Keyword(s):  
Myocardial Dysfunction ◽  
Signalling Pathway ◽  
Human Sepsis ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

scholarly journals PD‐1/PD‐L1 blockade rescue exhausted CD8+ T cells in gastrointestinal stromal tumours via the PI3K/Akt/mTOR signalling pathway

2019 ◽  
Vol 52 (3) ◽  
pp. e12571 ◽  
Author(s):  
Rui Zhao ◽  
Yinghan Song ◽  
Yong Wang ◽  
Yuqian Huang ◽  
Zhigui Li ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Signalling Pathway ◽  
Gastrointestinal Stromal Tumours ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

scholarly journals LncRNA MEG3 inhibits rheumatoid arthritis through miR‐141 and inactivation of AKT/mTOR signalling pathway

2019 ◽  
Vol 23 (10) ◽  
pp. 7116-7120 ◽  
Author(s):  
Guoqing Li ◽  
Ying Liu ◽  
Fanru Meng ◽  
Zhongbin Xia ◽  
Xia Wu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Signalling Pathway ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway
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