scholarly journals Luteolin, an aryl hydrocarbon receptor ligand, suppresses tumor metastasis in�vitro and in�vivo

2020 ◽  
Author(s):  
Jinhong Feng ◽  
Ting Zheng ◽  
Zhaohua Hou ◽  
Cui Lv ◽  
Anqi Xue ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Tumor Metastasis ◽  
Receptor Ligand ◽  
Aryl Hydrocarbon Receptor Ligand ◽  
Aryl Hydrocarbon

Comparative study of aryl hydrocarbon receptor ligand activities of six chemicals in vitro and in vivo

2007 ◽  
Vol 82 (1) ◽  
pp. 5-11 ◽  
Author(s):  
Kazumi Sugihara ◽  
Takashige Okayama ◽  
Shigeyuki Kitamura ◽  
Keisuke Yamashita ◽  
Mineo Yasuda ◽  
...  
Keyword(s):  
Comparative Study ◽  
Aryl Hydrocarbon Receptor ◽  
Receptor Ligand ◽  
Aryl Hydrocarbon Receptor Ligand ◽  
Aryl Hydrocarbon

scholarly journals Increase Paclitaxel Sensitivity to Better Suppress Serous Epithelial Ovarian Cancer via Ablating Androgen Receptor/Aryl Hydrocarbon Receptor-ABCG2 Axis

Cancers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 463 ◽  
Author(s):  
Wei-Min Chung ◽  
Yen-Ping Ho ◽  
Wei-Chun Chang ◽  
Yuan-Chang Dai ◽  
Lumin Chen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Androgen Receptor ◽  
Epithelial Ovarian Cancer ◽  
Aryl Hydrocarbon Receptor ◽  
Proximal Promoter ◽  
Luciferase Reporter ◽  
Aryl Hydrocarbon ◽  
Paclitaxel Treatment

Background: Epithelial ovarian cancer (EOC) is one of the most lethal gynecological malignancies and presents chemoresistance after chemotherapy treatment. Androgen receptor (AR) has been known to participate in proliferation. Yet the mechanisms of the resistance of this drug and its linkage to the AR remains unclear. Methods: To elucidate AR-related paclitaxel sensitivity, co-IP, luciferase reporter assay and ChIP assay were performed to identify that AR direct-regulated ABCG2 expression under paclitaxel treatment. IHC staining by AR antibody presented higher AR expression in serous-type patients than other types. AR degradation enhancer (ASC-J9) was used to examine paclitaxel-associated and paclitaxel-resistant cytotoxicity in vitro and in vivo. Results: We found AR/aryl hydrocarbon receptor (AhR)-mediates ABCG2 expression and leads to a change in paclitaxel cytotoxicity/sensitivity in EOC serous subtype cell lines. Molecular mechanism study showed that paclitaxel activated AR transactivity and bound to alternative ARE in the ABCG2 proximal promoter region. To identify AR as a potential therapeutic target, the ASC-J9 was used to re-sensitize paclitaxel-resistant EOC tumors upon paclitaxel treatment in vitro and in vivo. Conclusion: The results demonstrated that activation of AR transactivity beyond the androgen-associated biological effect. This novel AR mechanism explains that degradation of AR is the most effective therapeutic strategy for treating AR-positive EOC serous subtype.

ARYL HYDROCARBON RECEPTOR LIGAND ACTIVITY OF POLYCYCLIC AROMATIC KETONES AND POLYCYCLIC AROMATIC QUINONES

2007 ◽  
Vol 26 (7) ◽  
pp. 1370 ◽  
Author(s):  
Kentaro Misaki ◽  
Hirofumi Kawami ◽  
Tota Tanaka ◽  
Hiroshi Handa ◽  
Masafumi Nakamura ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Receptor Ligand ◽  
Aromatic Ketones ◽  
Aryl Hydrocarbon Receptor Ligand ◽  
Aryl Hydrocarbon ◽  
Polycyclic Aromatic ◽  
Ligand Activity

scholarly journals In Silico Identification of an Aryl Hydrocarbon Receptor Antagonist with Biological Activity In Vitro and In Vivo

2014 ◽  
Vol 86 (5) ◽  
pp. 593-608 ◽  
Author(s):  
Ashley J. Parks ◽  
Michael P. Pollastri ◽  
Mark E. Hahn ◽  
Elizabeth A. Stanford ◽  
Olga Novikov ◽  
...  
Keyword(s):  
Biological Activity ◽  
Receptor Antagonist ◽  
Aryl Hydrocarbon Receptor ◽  
In Silico ◽  
Aryl Hydrocarbon ◽  
In Silico Identification ◽  
Aryl Hydrocarbon Receptor Antagonist

Microbial Metabolites of Omeprazole Activate Murine Aryl Hydrocarbon Receptor In Vitro and In Vivo

2014 ◽  
Vol 42 (10) ◽  
pp. 1690-1697 ◽  
Author(s):  
Kazuhiro Shiizaki ◽  
Masanobu Kawanishi ◽  
Takashi Yagi
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Microbial Metabolites ◽  
Aryl Hydrocarbon
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