scholarly journals Aspirin inhibits hepatocellular carcinoma cell proliferation in vitro and in vivo via inducing cell cycle arrest and apoptosis

2020 ◽  
Vol 44 (2) ◽  
pp. 457-468
Author(s):  
Tingting Shi ◽  
Koji Fujita ◽  
Jian Gong ◽  
Mai Nakahara ◽  
Hisakazu Iwama ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Cycle Arrest ◽  
Carcinoma Cell ◽  
Cycle Arrest ◽  
Hepatocellular Carcinoma Cell ◽  
Proliferation In Vitro

scholarly journals Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest

2017 ◽  
Vol 38 (5) ◽  
pp. 2825-2835 ◽  
Author(s):  
Kyoko Oura ◽  
Tomoko Tadokoro ◽  
Shintaro Fujihara ◽  
Asahiro Morishita ◽  
Taiga Chiyo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Cycle Arrest ◽  
Carcinoma Cell ◽  
Cycle Arrest ◽  
Hepatocellular Carcinoma Cell ◽  
Proliferation In Vitro

scholarly journals Dysregulation of miR-23b-5p promotes cell proliferation via targeting FOXM1 in hepatocellular carcinoma

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Xinchen Yang ◽  
Shikun Yang ◽  
Jinhua Song ◽  
Wenjie Yang ◽  
Yang Ji ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Cycle Arrest ◽  
Tumor Development ◽  
Loss Of Function ◽  
Cycle Arrest ◽  
Cell Proliferation Inhibition

AbstractGrowing evidence demonstrates that MicroRNAs (miRNAs) play an essential role in contributing to tumor development and progression. However, the underlying role and mechanisms of miR-23b-5p in hepatocellular carcinoma (HCC) formation remain unclear. Our study showed that miR-23b-5p was downregulated in the HCC tissues and cell lines, and lower expression of miR-23b-5p was associated with more severe tumor size and poorer survival. Gain- or loss-of-function assays demonstrated that miR-23b-5p induced G0/G1 cell cycle arrest and inhibited cell proliferation both in vitro and in vivo. qRT-PCR, western blot and luciferase assays verified that Mammalian transcription factor Forkhead Box M1 (FOXM1), upregulated in HCC specimens, was negatively correlated with miR-23b-5p expression and acted as a direct downstream target of miR-23b-5p. In addition, miR-23b-5p could regulate cyclin D1 and c-MYC expression by directly targeting FOXM1. Further study revealed that restoration of FOXM1 neutralized the cell cycle arrest and cell proliferation inhibition caused by miR-23b-5p. Taken together, our findings suggest that miR-23b-5p acted as a tumor suppressor role in HCC progression by targeting FOXM1 and may serve as a potential novel biomarker for HCC diagnosis and prognosis.

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