scholarly journals Targeting YAP suppresses ovarian cancer progression through regulation of the PI3K/Akt/mTOR pathway

2019 ◽  
Author(s):  
Xiao Wei ◽  
Yijuan Jia ◽  
Hua Lou ◽  
Jingjing Ma ◽  
Quanfu Huang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Progression ◽  
Mtor Pathway

METTL3-mediated maturation of miR-126-5p promotes ovarian cancer progression via PTEN-mediated PI3K/Akt/mTOR pathway

2020 ◽  
Author(s):  
Xuehan Bi ◽  
Xiao Lv ◽  
Dajiang Liu ◽  
Hongtao Guo ◽  
Guang Yao ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Progression ◽  
Mtor Pathway

Daphnetin triggers ROS-induced cell death and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway in ovarian cancer

Phytomedicine ◽  
2021 ◽  
Vol 82 ◽  
pp. 153465
Author(s):  
Xiaoye Fan ◽  
Min Xie ◽  
Feijie Zhao ◽  
Jiajia Li ◽  
Changqing Fan ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Death ◽  
Mtor Pathway

scholarly journals Oncogenic Role of miR-200c-3p in High-Grade Serous Ovarian Cancer Progression via Targeting the 3′-Untranslated Region of DLC1

2021 ◽  
Vol 18 (11) ◽  
pp. 5741
Author(s):  
Sheril June Ankasha ◽  
Mohamad Nasir Shafiee ◽  
Norhazlina Abdul Wahab ◽  
Raja Affendi Raja Ali ◽  
Norfilza Mohd Mokhtar
Keyword(s):  
Ovarian Cancer ◽  
Cancer Progression ◽  
Untranslated Region ◽  
Luciferase Reporter ◽  
Clinical Samples ◽  
Binding Motif ◽  
Skov3 Cell ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Dlc1 Expression

High-grade serous ovarian cancer (HGSC) is the most common ovarian cancer with highly metastatic properties. A small non-coding RNA, microRNA (miRNA) was discovered to be a major regulator in many types of cancers through binding at the 3′-untranslated region (3′UTR), leading to degradation of the mRNA. In this study, we sought to investigate the underlying mechanisms involved in the dysregulation of miR-200c-3p in HGSC progression and metastasis. We identified the upregulation of miR-200c-3p expression in different stages of HGSC clinical samples and the downregulation of the tumor suppressor gene, Deleted in Liver Cancer 1 (DLC1), expression. Over expression of miR-200c-3p in HGSC cell lines downregulated DLC1 but upregulated the epithelial marker, E-cadherin (CDH1). Based on in silico analysis, two putative binding sites were found within the 3′UTR of DLC1, and we confirmed the direct binding of miR-200c-3p to the target binding motif at position 1488–1495 bp of 3′UTR of DLC1 by luciferase reporter assay in a SKOV3 cell line co-transfected with vectors and miR-200c-3p mimic. These data showed that miR-200c-3p regulated the progression of HGSC by regulating DLC1 expression post-transcription and can be considered as a promising target for therapeutic purposes.

scholarly journals Low-dose naltrexone plays antineoplastic role in cervical cancer progression through suppressing PI3K/AKT/mTOR pathway

2021 ◽  
Vol 14 (4) ◽  
pp. 101028
Author(s):  
Ning Liu ◽  
Limei Yan ◽  
Fengping Shan ◽  
Xiaonai Wang ◽  
Na Qu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Progression ◽  
Low Dose ◽  
Mtor Pathway ◽  
Low Dose Naltrexone
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