scholarly journals Vorinostat enhances gefitinib‑induced cell death through reactive oxygen species‑dependent cleavage of HSP90 and its clients in non‑small cell lung cancer with the EGFR mutation

2018 ◽  
Author(s):  
Sang Park ◽  
Dong Kim ◽  
Mi Kim ◽  
Jee Lee ◽  
Jin Rho ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Reactive Oxygen Species ◽  
Cell Death ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Egfr Mutation ◽  
Reactive Oxygen ◽  
Small Cell ◽  
Oxygen Species ◽  
Small Cell Lung

Curcumin exerts cytotoxicity dependent on reactive oxygen species accumulation in non-small-cell lung cancer cells

2019 ◽  
Vol 15 (11) ◽  
pp. 1243-1253 ◽  
Author(s):  
Cuijuan Wang ◽  
Xingguo Song ◽  
Ming Shang ◽  
Wei Zou ◽  
Mengping Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Reactive Oxygen Species ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Reactive Oxygen ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Oxygen Species ◽  
Small Cell Lung

scholarly journals Calotropis gigantea extract induces apoptosis through extrinsic/intrinsic pathways and upregulation of reactive oxygen species in non-small-cell lung cancer cells

2018 ◽  
Author(s):  
Jiyon Lee ◽  
Huiju Jang ◽  
Yesol Bak ◽  
Jong-Woon Shin ◽  
Hang Jin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Reactive Oxygen Species ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Reactive Oxygen ◽  
Small Cell ◽  
Oxygen Species ◽  
Small Cell Lung ◽  
Calotropis Gigantea ◽  
Dose Dependent

AbstractBackgroundCalotropis gigantea (CG) plant grows in Asia and tropical Africa. However, the precise mechanisms of its anticancer effects have not yet been examined in human non-small cell lung cancer (NSCLC) cells, A549 and NCI-H1299 cells.PurposeThis study was focused on the anti-cancer effects of CG extract on non-small cell lung cancer (NSCLC) cells.MethodsThe cytotoxic effects of CG extract on NSCLC, A549 and NCI-H1299 cells, were detected by MTS assay, microscope and DAPI staining. Apoptosis was determined by annexin V-FITC/PI staining, cell cycle analysis, western blotting, quantitative polymerase chain reaction, and JC-1 staining.ResultsFirst, CG showed significant dose-dependent cytotoxicity in NSCLC, A549, and NCI-H1299 cells. In addition to induction of caspase-8 processing, CG induced apoptosis by upregulating mRNA expression levels of extrinsic pathway molecules such as Fas, Fas ligand (FasL), Fas-associated protein with death domain (FADD) and death receptor 5 (DR5). Also, mitochondrial membrane potential (MMP) was collapsed, and intrinsic pathway molecules such as poly (ADP-ribose) polymerase (PARP), caspase-3, and caspase-9 were processed by CG. Moreover, reactive oxygen species (ROS) were generated in a CG dose-dependent manner, and inhibition of ROS by NAC, ROS scavenger, recovered A549 and NCI-H1299 cell viability.ConclusionThese results indicate that CG causes apoptosis by activating the extrinsic and intrinsic pathways and generating ROS in NSCLC cells. These results suggest that CG can be used as a lung cancer therapeutic agent.

Curcumin sensitizes non-small cell lung cancer cell anoikis through reactive oxygen species-mediated Bcl-2 downregulation

APOPTOSIS ◽  
2010 ◽  
Vol 15 (5) ◽  
pp. 574-585 ◽  
Author(s):  
Varisa Pongrakhananon ◽  
Ubonthip Nimmannit ◽  
Sudjit Luanpitpong ◽  
Yon Rojanasakul ◽  
Pithi Chanvorachote
Keyword(s):  
Lung Cancer ◽  
Reactive Oxygen Species ◽  
Small Cell Lung Cancer ◽  
Cancer Cell ◽  
Cell Lung Cancer ◽  
Reactive Oxygen ◽  
Small Cell ◽  
Oxygen Species ◽  
Lung Cancer Cell ◽  
Small Cell Lung

Serum reactive oxygen species modulator 1 (Romo1) as a potential diagnostic biomarker for non-small cell lung cancer

Lung Cancer ◽  
2014 ◽  
Vol 85 (2) ◽  
pp. 175-181 ◽  
Author(s):  
Seung Hyeun Lee ◽  
Ji Sung Lee ◽  
Eun Joo Lee ◽  
Kyung Hoon Min ◽  
Gyu Young Hur ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Reactive Oxygen Species ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Reactive Oxygen ◽  
Small Cell ◽  
Oxygen Species ◽  
Diagnostic Biomarker ◽  
Small Cell Lung

scholarly journals Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway

2021 ◽  
Vol 144 ◽  
pp. 112358
Author(s):  
Kirti.S. Prabhu ◽  
Ajaz A. Bhat ◽  
Kodappully S. Siveen ◽  
Shilpa Kuttikrishnan ◽  
Syed Shadab Raza ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Reactive Oxygen Species ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Reactive Oxygen ◽  
Small Cell ◽  
Oxygen Species ◽  
Small Cell Lung ◽  
Stat Pathway
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